OCA at 12:42, 26 July 2023

OCA — Wed, 26 Jul 2023 12:42:59 GMT

←Older revision		Revision as of 12:42, 26 July 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8sw1 is ~~ON HOLD until Paper~~ Publication	+	==Puromycin-sensitive aminopeptidase with bound peptide==
		+	<StructureSection load='8sw1' size='340' side='right'caption='[[8sw1]], [[Resolution\|resolution]] 3.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8sw1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SW1 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sw1 OCA], [https://pdbe.org/8sw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sw1 RCSB], [https://www.ebi.ac.uk/pdbsum/8sw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sw1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PSA_HUMAN PSA_HUMAN] Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.<ref>PMID:10978616</ref> <ref>PMID:11062501</ref> <ref>PMID:17154549</ref> <ref>PMID:17318184</ref> <ref>PMID:19917696</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc metallopeptidase belonging to the M1 family, degrades a number of bioactive peptides as well as peptides released from the proteasome, including polyglutamine. We report the crystal structure of PSA at 2.3 A. Overall, the enzyme adopts a V-shaped architecture with four domains characteristic of the M1 family aminopeptidases, but it is in a less compact conformation compared to most M1 enzymes of known structure. A microtubule binding sequence is present in a C-terminal HEAT repeat domain of the enzyme in a position where it might serve to mediate interaction with tubulin. In the catalytic metallopeptidase domain, an elongated active site groove lined with aromatic and hydrophobic residues and a large S1 subsite may play a role in broad substrate recognition. The structure with bound polyglutamine shows a possible interacting mode of this peptide, which is supported by mutation.

-	~~Authors~~:	+	Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.,Madabushi S, Chow KM, Song ES, Goswami A, Hersh LB, Rodgers DW PLoS One. 2023 Jul 13;18(7):e0287086. doi: 10.1371/journal.pone.0287086. , eCollection 2023. PMID:37440518<ref>PMID:37440518</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8sw1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Madabushi S]]
		+	[[Category: Rodgers DW]]

OCA at 08:29, 21 June 2023

OCA — Wed, 21 Jun 2023 08:29:07 GMT

←Older revision		Revision as of 08:29, 21 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8sw1 is ON HOLD	+	The entry 8sw1 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8sw1" [edit=sysop:move=sysop]

OCA — Thu, 25 May 2023 02:51:54 GMT

Protected "8sw1" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:51, 25 May 2023

OCA: New page: '''Unreleased structure''' The entry 8sw1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Thu, 25 May 2023 02:51:53 GMT

New page: '''Unreleased structure''' The entry 8sw1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8sw1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8sw1 - Revision history

OCA at 12:42, 26 July 2023

OCA at 08:29, 21 June 2023

OCA: Protected "8sw1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8sw1 is ON HOLD Authors: Description: Category: Unreleased Structures