OCA at 13:15, 1 November 2023

OCA — Wed, 01 Nov 2023 13:15:05 GMT

←Older revision		Revision as of 13:15, 1 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8syn is ~~ON HOLD until Paper Publication~~	+	==Human VPS35L/VPS29/VPS26C Complex==
-		+	<StructureSection load='8syn' size='340' side='right'caption='[[8syn]], [[Resolution\|resolution]] 2.94Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8syn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SYN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.94Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8syn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8syn OCA], [https://pdbe.org/8syn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8syn RCSB], [https://www.ebi.ac.uk/pdbsum/8syn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8syn ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/VP35L_HUMAN VP35L_HUMAN] The disease may be caused by variants affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/VP35L_HUMAN VP35L_HUMAN] Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947).<ref>PMID:25355947</ref> <ref>PMID:28892079</ref> (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.<ref>PMID:28892079</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Burstein E]]
		+	[[Category: Chen B]]
		+	[[Category: Chen Z]]
		+	[[Category: Han Y]]

OCA at 06:47, 14 June 2023

OCA — Wed, 14 Jun 2023 06:47:56 GMT

←Older revision		Revision as of 06:47, 14 June 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8syn is ON HOLD	+	The entry 8syn is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8syn" [edit=sysop:move=sysop]

OCA — Wed, 31 May 2023 04:17:43 GMT

Protected "8syn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:17, 31 May 2023

OCA: New page: '''Unreleased structure''' The entry 8syn is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 31 May 2023 04:17:42 GMT

New page: '''Unreleased structure''' The entry 8syn is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8syn is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8syn - Revision history

OCA at 13:15, 1 November 2023

OCA at 06:47, 14 June 2023

OCA: Protected "8syn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8syn is ON HOLD Authors: Description: Category: Unreleased Structures