OCA at 13:18, 13 March 2024

OCA — Wed, 13 Mar 2024 13:18:31 GMT

←Older revision		Revision as of 13:18, 13 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8t7t is ~~ON HOLD until Paper Publication~~	+	==CryoEM structure of the HisRS-like domain of human GCN2==
-		+	<StructureSection load='8t7t' size='340' side='right'caption='[[8t7t]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8t7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T7T FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t7t OCA], [https://pdbe.org/8t7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t7t RCSB], [https://www.ebi.ac.uk/pdbsum/8t7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t7t ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/E2AK4_HUMAN E2AK4_HUMAN] Pulmonary venoocclusive disease;Pulmonary capillary hemangiomatosis;Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E2AK4_HUMAN E2AK4_HUMAN] Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).[UniProtKB:P15442][UniProtKB:Q9QZ05]<ref>PMID:25329545</ref> <ref>PMID:26102367</ref> (Microbial infection) Plays a role in modulating the adaptive immune response to yellow fever virus infection; promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation (PubMed:24310610).<ref>PMID:24310610</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Keszei AFA]]
		+	[[Category: Mazhab-Jafari MT]]
		+	[[Category: Sicheri F]]
		+	[[Category: Yin JZ]]

OCA: Protected "8t7t" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 20:07:52 GMT

Protected "8t7t" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:07, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8t7t is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jun 2023 20:07:47 GMT

New page: '''Unreleased structure''' The entry 8t7t is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8t7t is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8t7t - Revision history

OCA at 13:18, 13 March 2024

OCA: Protected "8t7t" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8t7t is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures