OCA at 09:20, 30 August 2023

OCA — Wed, 30 Aug 2023 09:20:13 GMT

←Older revision		Revision as of 09:20, 30 August 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8t8k is ~~ON HOLD until Paper~~ Publication	+	==Structure of Domain of Unknown Function 507 (DUF507) in Space Group C222(1)==
		+	<StructureSection load='8t8k' size='340' side='right'caption='[[8t8k]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8t8k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T8K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T8K FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t8k OCA], [https://pdbe.org/8t8k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t8k RCSB], [https://www.ebi.ac.uk/pdbsum/8t8k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t8k ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O67633_AQUAE O67633_AQUAE]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the domain of unknown function family 507 protein from Aquifex aeolicus is reported (AaDUF507, UniProt O67633, 183 residues). The structure was determined in two space groups (C222(1) and P3(2)21) at 1.9 A resolution. The phase problem was solved by molecular replacement using an AlphaFold model as the search model. AaDUF507 is a Y-shaped alpha-helical protein consisting of an anti-parallel 4-helix bundle base and two helical arms that extend 30-A from the base. The two crystal structures differ by a 25 degrees rigid body rotation of the C-terminal arm. The tertiary structure exhibits pseudo-twofold symmetry. The structural symmetry mirrors internal sequence similarity: residues 11-57 and 102-148 are 30% identical and 53% similar with an E-value of 0.002. In one of the structures, electron density for an unknown ligand, consistent with nicotinamide or similar molecule, may indicate a functional site. Docking calculations suggest potential ligand binding hot spots in the region between the helical arms. Structure-based query of the Protein Data Bank revealed no other protein with a similar tertiary structure, leading us to propose that AaDUF507 represents a new protein fold.

-	~~Authors~~:	+	Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold.,McKay CE, Cheng J, Tanner JJ Sci Rep. 2023 Aug 18;13(1):13496. doi: 10.1038/s41598-023-40558-y. PMID:37596303<ref>PMID:37596303</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8t8k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aquifex aeolicus]]
		+	[[Category: Large Structures]]
		+	[[Category: McKay CE]]
		+	[[Category: Tanner JJ]]

OCA at 04:25, 5 July 2023

OCA — Wed, 05 Jul 2023 04:25:09 GMT

←Older revision		Revision as of 04:25, 5 July 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8t8k is ON HOLD	+	The entry 8t8k is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8t8k" [edit=sysop:move=sysop]

OCA — Wed, 28 Jun 2023 20:10:22 GMT

Protected "8t8k" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:10, 28 June 2023

OCA: New page: '''Unreleased structure''' The entry 8t8k is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Jun 2023 20:10:21 GMT

New page: '''Unreleased structure''' The entry 8t8k is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8t8k is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8t8k - Revision history

OCA at 09:20, 30 August 2023

OCA at 04:25, 5 July 2023

OCA: Protected "8t8k" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8t8k is ON HOLD Authors: Description: Category: Unreleased Structures