OCA at 06:23, 1 May 2024

OCA — Wed, 01 May 2024 06:23:19 GMT

←Older revision		Revision as of 06:23, 1 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8t9v is ~~ON HOLD until Paper Publication~~	+	==RTA-RUNT-59 complex structure==
-		+	<StructureSection load='8t9v' size='340' side='right'caption='[[8t9v]], [[Resolution\|resolution]] 1.94Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8t9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T9V FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.945Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ZJT:(9aP)-7-fluoro-4,5-dihydronaphtho[1,2-b]thiophene-2-carboxylic+acid'>ZJT</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t9v OCA], [https://pdbe.org/8t9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t9v RCSB], [https://www.ebi.ac.uk/pdbsum/8t9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t9v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ricinus communis]]
		+	[[Category: Rudolph MJ]]
		+	[[Category: Tumer N]]

OCA at 09:21, 2 August 2023

OCA — Wed, 02 Aug 2023 09:21:16 GMT

←Older revision		Revision as of 09:21, 2 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8t9v is ON HOLD	+	The entry 8t9v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8t9v" [edit=sysop:move=sysop]

OCA — Wed, 05 Jul 2023 04:27:18 GMT

Protected "8t9v" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 5 July 2023

OCA: New page: '''Unreleased structure''' The entry 8t9v is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Jul 2023 04:27:17 GMT

New page: '''Unreleased structure''' The entry 8t9v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8t9v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8t9v - Revision history

OCA at 06:23, 1 May 2024

OCA at 09:21, 2 August 2023

OCA: Protected "8t9v" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8t9v is ON HOLD Authors: Description: Category: Unreleased Structures