8ta5 - Revision history

OCA at 11:46, 1 February 2024

OCA — Thu, 01 Feb 2024 11:46:31 GMT

←Older revision		Revision as of 11:46, 1 February 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ta5 ~~is ON HOLD until Paper Publication~~	+	==Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal==
-		+	<StructureSection load='8ta5' size='340' side='right'caption='[[8ta5]], [[Resolution\|resolution]] 2.76Å' scene=''>
-	~~Authors~~: ~~Xu, M~~.~~, Neelands, T~~.~~, Powers, A~~.S.~~, Liu, Y~~., ~~Miller, S~~., ~~Pintilie, G~~., ~~Du Bois, J~~., ~~Dror, R~~.O., ~~Chiu, W~~., ~~Maduke, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ta5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TA5 FirstGlance]. <br>
-	~~Description~~: ~~Title~~: ~~Cryo~~-~~EM structure~~ of the ~~human CLC~~-~~2 chloride channel transmembrane domain with asymmetric C~~-~~terminal~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.76Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[Category: ~~Miller, S~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ta5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ta5 OCA], [https://pdbe.org/8ta5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ta5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ta5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ta5 ProSAT]</span></td></tr>
-	[[Category: Chiu, W]]	+	</table>
-	[[Category: ~~Powers, A.S~~]]	+	== Disease ==
-	[[Category: Du Bois, J]]	+	[https://www.uniprot.org/uniprot/CLCN2_HUMAN CLCN2_HUMAN] Leukoencephalopathy with mild cerebellar ataxia and white matter edema;Familial hyperaldosteronism type II;Juvenile myoclonic epilepsy. Disease susceptibility is associated with variants affecting the gene represented in this entry. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
-	[[Category: ~~Pintilie, G~~]]	+	== Function ==
-	[[Category: ~~Neelands, T~~]]	+	[https://www.uniprot.org/uniprot/CLCN2_HUMAN CLCN2_HUMAN] Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011, PubMed:29403012).<ref>PMID:19153159</ref> <ref>PMID:19191339</ref> <ref>PMID:29403011</ref> <ref>PMID:29403012</ref>
-	[[Category: ~~Xu, M~~]]	+	== References ==
-	[[Category: ~~Liu, Y~~]]	+	<references/>
-	[[Category: ~~Maduke, M~~]]	+	__TOC__
-	[[Category: ~~Dror, R.O~~]]	+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chiu W]]
		+	[[Category: Dror RO]]
		+	[[Category: Du Bois J]]
		+	[[Category: Liu Y]]
		+	[[Category: Maduke M]]
		+	[[Category: Miller S]]
		+	[[Category: Neelands T]]
		+	[[Category: Pintilie G]]
		+	[[Category: Powers AS]]
		+	[[Category: Xu M]]

OCA at 11:11, 26 July 2023

OCA — Wed, 26 Jul 2023 11:11:14 GMT

←Older revision		Revision as of 11:11, 26 July 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ta5 is ON HOLD	+	The entry 8ta5 is ON HOLD until Paper Publication

	Authors: Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.		Authors: Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.
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	Description: Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal		Description: Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Maduke, M]]
-	[[Category: Dror, R.O]]
	[[Category: Miller, S]]		[[Category: Miller, S]]
	[[Category: Chiu, W]]		[[Category: Chiu, W]]
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	[[Category: Xu, M]]		[[Category: Xu, M]]
	[[Category: Liu, Y]]		[[Category: Liu, Y]]
		+	[[Category: Maduke, M]]
		+	[[Category: Dror, R.O]]

OCA: Protected "8ta5" [edit=sysop:move=sysop]

OCA — Wed, 05 Jul 2023 04:27:47 GMT

Protected "8ta5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:27, 5 July 2023

OCA: New page: '''Unreleased structure''' The entry 8ta5 is ON HOLD Authors: Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M. Descr...

OCA — Wed, 05 Jul 2023 04:27:46 GMT

New page: '''Unreleased structure''' The entry 8ta5 is ON HOLD Authors: Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M. Descr...

New page

'''Unreleased structure'''

The entry 8ta5 is ON HOLD

Authors: Xu, M., Neelands, T., Powers, A.S., Liu, Y., Miller, S., Pintilie, G., Du Bois, J., Dror, R.O., Chiu, W., Maduke, M.

Description: Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
[[Category: Unreleased Structures]]
[[Category: Maduke, M]]
[[Category: Dror, R.O]]
[[Category: Miller, S]]
[[Category: Chiu, W]]
[[Category: Powers, A.S]]
[[Category: Du Bois, J]]
[[Category: Pintilie, G]]
[[Category: Neelands, T]]
[[Category: Xu, M]]
[[Category: Liu, Y]]