OCA at 15:04, 13 March 2024

OCA — Wed, 13 Mar 2024 15:04:59 GMT

←Older revision		Revision as of 15:04, 13 March 2024
Line 11:		Line 11:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>		[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+
		+	==See Also==
		+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:48, 13 December 2023

OCA — Wed, 13 Dec 2023 11:48:04 GMT

←Older revision		Revision as of 11:48, 13 December 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8tdn is ~~ON HOLD until Paper Publication~~	+	==Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology==
-		+	<StructureSection load='8tdn' size='340' side='right'caption='[[8tdn]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~: ~~Nguyen~~, B.A., ~~Singh~~, V., ~~Saelices~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tdn]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TDN FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of ~~cardiac~~ amyloid ~~fibril from a variant ATTR I84S~~ amyloidosis ~~patient-3~~, ~~wild~~-type ~~morphology~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tdn OCA], [https://pdbe.org/8tdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tdn RCSB], [https://www.ebi.ac.uk/pdbsum/8tdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tdn ProSAT]</span></td></tr>
-	[[Category: Nguyen~~, B.A~~]]	+	</table>
-	[[Category: Saelices, L]]	+	== Disease ==
-	[[Category: Singh, V]]	+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR) [MIM:[https://omim.org/entry/105210 105210]. A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.<ref>PMID:11243784</ref> <ref>PMID:15735344</ref> <ref>PMID:19167329</ref> <ref>PMID:3818577</ref> <ref>PMID:3022108</ref> <ref>PMID:6651852</ref> <ref>PMID:6583672</ref> <ref>PMID:3135807</ref> <ref>PMID:1517749</ref> <ref>PMID:1932142</ref> <ref>PMID:7923855</ref> <ref>PMID:8382610</ref> <ref>PMID:8428915</ref> <ref>PMID:9733771</ref> <ref>PMID:12403615</ref> <ref>PMID:16185074</ref> <ref>PMID:16627944</ref> <ref>PMID:6487335</ref> <ref>PMID:3722385</ref> <ref>PMID:2891727</ref> <ref>PMID:2161654</ref> <ref>PMID:2363717</ref> <ref>PMID:1656975</ref> <ref>PMID:2046936</ref> <ref>PMID:1570831</ref> <ref>PMID:1734866</ref> <ref>PMID:1520326</ref> <ref>PMID:1520336</ref> <ref>PMID:1544214</ref> <ref>PMID:1351039</ref> <ref>PMID:1301926</ref> <ref>PMID:1362222</ref> <ref>PMID:1436517</ref> <ref>PMID:8352764</ref> <ref>PMID:8038017</ref> <ref>PMID:8257997</ref> <ref>PMID:8095302</ref> <ref>PMID:1997217</ref> <ref>PMID:8019560</ref> <ref>PMID:8081397</ref> <ref>PMID:7914929</ref> <ref>PMID:8133316</ref> <ref>PMID:7910950</ref> <ref>PMID:7655883</ref> <ref>PMID:7850982</ref> <ref>PMID:8579098</ref> <ref>PMID:9066351</ref> <ref>PMID:8990019</ref> <ref>PMID:9605286</ref> <ref>PMID:10036587</ref> <ref>PMID:10627135</ref> <ref>PMID:10694917</ref> <ref>PMID:10211412</ref> <ref>PMID:10439117</ref> <ref>PMID:10611950</ref> <ref>PMID:10071047</ref> <ref>PMID:10436378</ref> <ref>PMID:10842705</ref> <ref>PMID:10842718</ref> <ref>PMID:10882995</ref> <ref>PMID:11445644</ref> <ref>PMID:12557757</ref> <ref>PMID:11866053</ref> <ref>PMID:12050338</ref> <ref>PMID:12771253</ref> <ref>PMID:15214015</ref> <ref>PMID:15478468</ref> <ref>PMID:15217993</ref> <ref>PMID:17453626</ref> <ref>PMID:17577687</ref> <ref>PMID:17503405</ref> <ref>PMID:17635579</ref> Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) [MIM:[https://omim.org/entry/145680 145680]. It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.<ref>PMID:1979335</ref> Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1) [MIM:[https://omim.org/entry/115430 115430]. It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.<ref>PMID:8309582</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TTHY_HUMAN TTHY_HUMAN] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:3714052</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Nguyen BA]]
		+	[[Category: Saelices L]]
		+	[[Category: Singh V]]

OCA at 05:02, 19 July 2023

OCA — Wed, 19 Jul 2023 05:02:13 GMT

←Older revision		Revision as of 05:02, 19 July 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tdn is ON HOLD	+	The entry 8tdn is ON HOLD until Paper Publication

	Authors: Nguyen, B.A., Singh, V., Saelices, L.		Authors: Nguyen, B.A., Singh, V., Saelices, L.

OCA: Protected "8tdn" [edit=sysop:move=sysop]

OCA — Wed, 12 Jul 2023 04:40:24 GMT

Protected "8tdn" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:40, 12 July 2023

OCA: New page: '''Unreleased structure''' The entry 8tdn is ON HOLD Authors: Nguyen, B.A., Singh, V., Saelices, L. Description: Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S am...

OCA — Wed, 12 Jul 2023 04:40:23 GMT

New page: '''Unreleased structure''' The entry 8tdn is ON HOLD Authors: Nguyen, B.A., Singh, V., Saelices, L. Description: Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S am...

New page

'''Unreleased structure'''

The entry 8tdn is ON HOLD

Authors: Nguyen, B.A., Singh, V., Saelices, L.

Description: Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology
[[Category: Unreleased Structures]]
[[Category: Nguyen, B.A]]
[[Category: Saelices, L]]
[[Category: Singh, V]]

8tdn - Revision history

OCA at 15:04, 13 March 2024

OCA at 11:48, 13 December 2023

OCA at 05:02, 19 July 2023

OCA: Protected "8tdn" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tdn is ON HOLD Authors: Nguyen, B.A., Singh, V., Saelices, L. Description: Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S am...