OCA at 12:09, 6 March 2024

OCA — Wed, 06 Mar 2024 12:09:55 GMT

←Older revision		Revision as of 12:09, 6 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8tep is ~~ON HOLD until Paper Publication~~	+	==Human cytomegalovirus portal vertex, virion configuration 1 (VC1)==
-		+	<StructureSection load='8tep' size='340' side='right'caption='[[8tep]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tep]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_5_strain_AD169 Human herpesvirus 5 strain AD169]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TEP FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tep OCA], [https://pdbe.org/8tep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tep RCSB], [https://www.ebi.ac.uk/pdbsum/8tep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tep ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LTP_HCMVA LTP_HCMVA] Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.[HAMAP-Rule:MF_04044]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human herpesvirus 5 strain AD169]]
		+	[[Category: Large Structures]]
		+	[[Category: Jih J]]
		+	[[Category: Liu W]]
		+	[[Category: Liu YT]]
		+	[[Category: Zhou H]]

OCA at 04:14, 9 August 2023

OCA — Wed, 09 Aug 2023 04:14:35 GMT

←Older revision		Revision as of 04:14, 9 August 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tep is ON HOLD	+	The entry 8tep is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8tep" [edit=sysop:move=sysop]

OCA — Wed, 12 Jul 2023 04:44:13 GMT

Protected "8tep" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:44, 12 July 2023

OCA: New page: '''Unreleased structure''' The entry 8tep is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 12 Jul 2023 04:44:10 GMT

New page: '''Unreleased structure''' The entry 8tep is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8tep is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8tep - Revision history

OCA at 12:09, 6 March 2024

OCA at 04:14, 9 August 2023

OCA: Protected "8tep" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tep is ON HOLD Authors: Description: Category: Unreleased Structures