OCA at 07:22, 14 February 2024

OCA — Wed, 14 Feb 2024 07:22:26 GMT

←Older revision		Revision as of 07:22, 14 February 2024
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-	'''Unreleased structure'''

-	~~The entry 8tja is ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6'-SLNLN==
-		+	<StructureSection load='8tja' size='340' side='right'caption='[[8tja]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~Authors: Wu, N.C., Zhu, X., Wilson, I.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/H3N2_subtype H3N2 subtype]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TJA FirstGlance]. <br>
-	~~Description:~~ CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6''-SLNLN	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Wilson~~, I.A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tja OCA], [https://pdbe.org/8tja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tja RCSB], [https://www.ebi.ac.uk/pdbsum/8tja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tja ProSAT]</span></td></tr>
-	[[Category: ~~Zhu, X~~]]	+	</table>
-	[[Category: Wu~~, N.C~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A4P8J8E1_9INFA A0A4P8J8E1_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: H3N2 subtype]]
		+	[[Category: Large Structures]]
		+	[[Category: Wilson IA]]
		+	[[Category: Wu NC]]
		+	[[Category: Zhu X]]

OCA at 06:54, 16 August 2023

OCA — Wed, 16 Aug 2023 06:54:57 GMT

←Older revision		Revision as of 06:54, 16 August 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tja is ON HOLD	+	The entry 8tja is ON HOLD until Paper Publication

	Authors: Wu, N.C., Zhu, X., Wilson, I.A.		Authors: Wu, N.C., Zhu, X., Wilson, I.A.
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	Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6''-SLNLN		Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6''-SLNLN
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wu, N.C]]
	[[Category: Wilson, I.A]]		[[Category: Wilson, I.A]]
	[[Category: Zhu, X]]		[[Category: Zhu, X]]
		+	[[Category: Wu, N.C]]

OCA: Protected "8tja" [edit=sysop:move=sysop]

OCA — Wed, 26 Jul 2023 11:17:31 GMT

Protected "8tja" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:17, 26 July 2023

OCA: New page: '''Unreleased structure''' The entry 8tja is ON HOLD Authors: Wu, N.C., Zhu, X., Wilson, I.A. Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTI...

OCA — Wed, 26 Jul 2023 11:17:27 GMT

New page: '''Unreleased structure''' The entry 8tja is ON HOLD Authors: Wu, N.C., Zhu, X., Wilson, I.A. Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTI...

New page

'''Unreleased structure'''

The entry 8tja is ON HOLD

Authors: Wu, N.C., Zhu, X., Wilson, I.A.

Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6''-SLNLN
[[Category: Unreleased Structures]]
[[Category: Wu, N.C]]
[[Category: Wilson, I.A]]
[[Category: Zhu, X]]

8tja - Revision history

OCA at 07:22, 14 February 2024

OCA at 06:54, 16 August 2023

OCA: Protected "8tja" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tja is ON HOLD Authors: Wu, N.C., Zhu, X., Wilson, I.A. Description: CRYSTAL STRUCTURE OF THE A/Ecuador/1374/2016(H3N2) INFLUENZA VIRUS HEMAGGLUTI...