OCA at 05:30, 17 April 2024

OCA — Wed, 17 Apr 2024 05:30:19 GMT

←Older revision		Revision as of 05:30, 17 April 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8tlz is ~~ON HOLD until Paper Publication~~	+	==Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys==
-		+	<StructureSection load='8tlz' size='340' side='right'caption='[[8tlz]], [[Resolution\|resolution]] 2.75Å' scene=''>
-	~~Authors~~: ~~Rupert~~, P.B., ~~Strong~~, R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TLZ FirstGlance]. <br>
-	~~Description~~: ~~Preclinical Characterization~~ of ~~Pan~~-~~NKG2D Ligand~~-~~Binding~~ NKG2D ~~Receptor Decoys~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Strong, R~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tlz OCA], [https://pdbe.org/8tlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tlz RCSB], [https://www.ebi.ac.uk/pdbsum/8tlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tlz ProSAT]</span></td></tr>
-	[[Category: Rupert~~, P.B~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/MICA_HUMAN MICA_HUMAN] Note=Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma. Genetic variations in MICA may be a cause of susceptibility to psoriasis type 1 (PSORS1) [MIM:[https://omim.org/entry/177900 177900]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Genetic variation in MICA is a cause of susceptibility to psoriatic arthritis (PSORAS) [MIM:[https://omim.org/entry/607507 607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MICA_HUMAN MICA_HUMAN] Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.<ref>PMID:9497295</ref> <ref>PMID:10426993</ref> <ref>PMID:11491531</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Rupert PB]]
		+	[[Category: Strong R]]

OCA at 04:39, 6 September 2023

OCA — Wed, 06 Sep 2023 04:39:35 GMT

←Older revision		Revision as of 04:39, 6 September 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tlz is ON HOLD	+	The entry 8tlz is ON HOLD until Paper Publication

	Authors: Rupert, P.B., Strong, R.		Authors: Rupert, P.B., Strong, R.
Line 7:		Line 7:
	Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys		Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Rupert, P.B]]
	[[Category: Strong, R]]		[[Category: Strong, R]]
		+	[[Category: Rupert, P.B]]

OCA: Protected "8tlz" [edit=sysop:move=sysop]

OCA — Wed, 02 Aug 2023 09:27:53 GMT

Protected "8tlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:27, 2 August 2023

OCA: New page: '''Unreleased structure''' The entry 8tlz is ON HOLD Authors: Rupert, P.B., Strong, R. Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys [[Cat...

OCA — Wed, 02 Aug 2023 09:27:50 GMT

New page: '''Unreleased structure''' The entry 8tlz is ON HOLD Authors: Rupert, P.B., Strong, R. Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys [[Cat...

New page

'''Unreleased structure'''

The entry 8tlz is ON HOLD

Authors: Rupert, P.B., Strong, R.

Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys
[[Category: Unreleased Structures]]
[[Category: Rupert, P.B]]
[[Category: Strong, R]]

8tlz - Revision history

OCA at 05:30, 17 April 2024

OCA at 04:39, 6 September 2023

OCA: Protected "8tlz" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tlz is ON HOLD Authors: Rupert, P.B., Strong, R. Description: Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys [[Cat...