OCA at 08:36, 9 May 2024

OCA — Thu, 09 May 2024 08:36:25 GMT

←Older revision		Revision as of 08:36, 9 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 8tng is ON HOLD until Paper Publication~~	+	==Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site==
-		+	<StructureSection load='8tng' size='340' side='right'caption='[[8tng]], [[Resolution\|resolution]] 3.58Å' scene=''>
-	~~Authors: Zhou, T., Kwong, P.D., Xu, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tng]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TNG FirstGlance]. <br>
-	~~Description:~~ Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.58Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Kwong~~, P.D~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tng OCA], [https://pdbe.org/8tng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tng RCSB], [https://www.ebi.ac.uk/pdbsum/8tng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tng ProSAT]</span></td></tr>
-	[[Category: Xu, J]]	+	</table>
-	[[Category: Zhou, T]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Lama glama]]
		+	[[Category: Large Structures]]
		+	[[Category: Kwong PD]]
		+	[[Category: Xu J]]
		+	[[Category: Zhou T]]

OCA at 04:40, 6 September 2023

OCA — Wed, 06 Sep 2023 04:40:59 GMT

←Older revision		Revision as of 04:40, 6 September 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tng is ON HOLD	+	The entry 8tng is ON HOLD until Paper Publication

	Authors: Zhou, T., Kwong, P.D., Xu, J.		Authors: Zhou, T., Kwong, P.D., Xu, J.

OCA: Protected "8tng" [edit=sysop:move=sysop]

OCA — Wed, 09 Aug 2023 04:18:07 GMT

Protected "8tng" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 9 August 2023

OCA: New page: '''Unreleased structure''' The entry 8tng is ON HOLD Authors: Zhou, T., Kwong, P.D., Xu, J. Description: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutraliz...

OCA — Wed, 09 Aug 2023 04:18:06 GMT

New page: '''Unreleased structure''' The entry 8tng is ON HOLD Authors: Zhou, T., Kwong, P.D., Xu, J. Description: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutraliz...

New page

'''Unreleased structure'''

The entry 8tng is ON HOLD

Authors: Zhou, T., Kwong, P.D., Xu, J.

Description: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site
[[Category: Unreleased Structures]]
[[Category: Kwong, P.D]]
[[Category: Xu, J]]
[[Category: Zhou, T]]

8tng - Revision history

OCA at 08:36, 9 May 2024

OCA at 04:40, 6 September 2023

OCA: Protected "8tng" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tng is ON HOLD Authors: Zhou, T., Kwong, P.D., Xu, J. Description: Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutraliz...