OCA at 06:28, 6 September 2023

OCA — Wed, 06 Sep 2023 06:28:58 GMT

←Older revision		Revision as of 06:28, 6 September 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8tv4 is ~~ON HOLD~~	+	==NMR structure of temporin L in solution==
-		+	<StructureSection load='8tv4' size='340' side='right'caption='[[8tv4]]' scene=''>
-	~~Authors~~: ~~McShan~~, A.C., ~~Jia~~, R., ~~Halim~~, M.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tv4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rana_temporaria Rana temporaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TV4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TV4 FirstGlance]. <br>
-	~~Description~~: ~~NMR structure~~ of temporin L in ~~solution~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tv4 OCA], [https://pdbe.org/8tv4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tv4 RCSB], [https://www.ebi.ac.uk/pdbsum/8tv4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tv4 ProSAT]</span></td></tr>
-	[[Category: ~~Halim, M.A~~]]	+	</table>
-	[[Category: ~~Mcshan, A.C~~]]	+	== Function ==
-	[[Category: Jia, R]]	+	[https://www.uniprot.org/uniprot/TPL_RANTE TPL_RANTE] Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:9022710, PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802). Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802). Also displays anti-leishmania activity by damaging parasite membrane (By similarity). Shows hemolytic activity (PubMed:12133008). Also shows cytotoxicity against cancer cell lines (PubMed:12133008). Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (PubMed:16801429) (Probable). Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570). In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).[UniProtKB:P56917][UniProtKB:P79874]<ref>PMID:12133008</ref> <ref>PMID:16801429</ref> <ref>PMID:16867990</ref> <ref>PMID:18370376</ref> <ref>PMID:21586570</ref> <ref>PMID:31358802</ref> <ref>PMID:9022710</ref> <ref>PMID:21586570</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rana temporaria]]
		+	[[Category: Halim MA]]
		+	[[Category: Jia R]]
		+	[[Category: McShan AC]]

OCA: Protected "8tv4" [edit=sysop:move=sysop]

OCA — Wed, 23 Aug 2023 04:53:30 GMT

Protected "8tv4" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 23 August 2023

OCA: New page: '''Unreleased structure''' The entry 8tv4 is ON HOLD Authors: McShan, A.C., Jia, R., Halim, M.A. Description: NMR structure of temporin L in solution [[Category: Unreleased Structures]...

OCA — Wed, 23 Aug 2023 04:53:29 GMT

New page: '''Unreleased structure''' The entry 8tv4 is ON HOLD Authors: McShan, A.C., Jia, R., Halim, M.A. Description: NMR structure of temporin L in solution [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 8tv4 is ON HOLD

Authors: McShan, A.C., Jia, R., Halim, M.A.

Description: NMR structure of temporin L in solution
[[Category: Unreleased Structures]]
[[Category: Halim, M.A]]
[[Category: Mcshan, A.C]]
[[Category: Jia, R]]

8tv4 - Revision history

OCA at 06:28, 6 September 2023

OCA: Protected "8tv4" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8tv4 is ON HOLD Authors: McShan, A.C., Jia, R., Halim, M.A. Description: NMR structure of temporin L in solution [[Category: Unreleased Structures]...