8tzu - Revision history

OCA at 06:23, 1 May 2024

OCA — Wed, 01 May 2024 06:23:37 GMT

←Older revision		Revision as of 06:23, 1 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8tzu is ~~ON HOLD until Paper Publication~~	+	==OC43 S1b domain in complex with WNb 293 and WNb 317==
-		+	<StructureSection load='8tzu' size='340' side='right'caption='[[8tzu]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~Authors~~: ~~Pymm~~, P., ~~Feng~~, J., ~~Tham~~, W.H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8tzu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_coronavirus_OC43 Human coronavirus OC43] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TZU FirstGlance]. <br>
-	~~Description~~: ~~OC43 S1b domain in complex~~ with ~~WNb 293~~ and ~~WNb 317~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: Feng, J]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tzu OCA], [https://pdbe.org/8tzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tzu RCSB], [https://www.ebi.ac.uk/pdbsum/8tzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tzu ProSAT]</span></td></tr>
-	[[Category: Pymm, P]]	+	</table>
-	[[Category: Tham~~, W.H~~]]	+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_CVHOC SPIKE_CVHOC] S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human coronavirus OC43]]
		+	[[Category: Large Structures]]
		+	[[Category: Vicugna pacos]]
		+	[[Category: Feng J]]
		+	[[Category: Pymm P]]
		+	[[Category: Tham WH]]

OCA at 07:19, 29 November 2023

OCA — Wed, 29 Nov 2023 07:19:44 GMT

←Older revision		Revision as of 07:19, 29 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tzu is ON HOLD	+	The entry 8tzu is ON HOLD until Paper Publication

	Authors: Pymm, P., Feng, J., Tham, W.H.		Authors: Pymm, P., Feng, J., Tham, W.H.

OCA at 05:55, 22 November 2023

OCA — Wed, 22 Nov 2023 05:55:39 GMT

←Older revision		Revision as of 05:55, 22 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tzu is ON HOLD ~~until Paper Publication~~	+	The entry 8tzu is ON HOLD

	Authors: Pymm, P., Feng, J., Tham, W.H.		Authors: Pymm, P., Feng, J., Tham, W.H.

OCA at 05:28, 15 November 2023

OCA — Wed, 15 Nov 2023 05:28:41 GMT

←Older revision		Revision as of 05:28, 15 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tzu is ON HOLD	+	The entry 8tzu is ON HOLD until Paper Publication

	Authors: Pymm, P., Feng, J., Tham, W.H.		Authors: Pymm, P., Feng, J., Tham, W.H.

OCA at 12:19, 18 October 2023

OCA — Wed, 18 Oct 2023 12:19:43 GMT

←Older revision		Revision as of 12:19, 18 October 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8tzu is ON HOLD ~~until sometime in the future~~	+	The entry 8tzu is ON HOLD

	Authors: Pymm, P., Feng, J., Tham, W.H.		Authors: Pymm, P., Feng, J., Tham, W.H.

OCA: Protected "8tzu" [edit=sysop:move=sysop]

OCA — Wed, 06 Sep 2023 04:48:50 GMT

Protected "8tzu" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:48, 6 September 2023

OCA: New page: '''Unreleased structure''' The entry 8tzu is ON HOLD until sometime in the future Authors: Pymm, P., Feng, J., Tham, W.H. Description: OC43 S1b domain in complex with WNb 293 and WNb 3...

OCA — Wed, 06 Sep 2023 04:48:47 GMT

New page: '''Unreleased structure''' The entry 8tzu is ON HOLD until sometime in the future Authors: Pymm, P., Feng, J., Tham, W.H. Description: OC43 S1b domain in complex with WNb 293 and WNb 3...

New page

'''Unreleased structure'''

The entry 8tzu is ON HOLD until sometime in the future

Authors: Pymm, P., Feng, J., Tham, W.H.

Description: OC43 S1b domain in complex with WNb 293 and WNb 317
[[Category: Unreleased Structures]]
[[Category: Feng, J]]
[[Category: Pymm, P]]
[[Category: Tham, W.H]]