OCA at 08:37, 9 May 2024

OCA — Thu, 09 May 2024 08:37:18 GMT

←Older revision		Revision as of 08:37, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8u2z is ~~ON HOLD until Paper Publication~~	+	==TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state==
-		+	<StructureSection load='8u2z' size='340' side='right'caption='[[8u2z]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8u2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U2Z FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u2z OCA], [https://pdbe.org/8u2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u2z RCSB], [https://www.ebi.ac.uk/pdbsum/8u2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u2z ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRPV1_RAT TRPV1_RAT] Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.<ref>PMID:9349813</ref> <ref>PMID:10644739</ref> <ref>PMID:11140687</ref> <ref>PMID:11418861</ref> <ref>PMID:12095983</ref> <ref>PMID:12194871</ref> <ref>PMID:12808128</ref> <ref>PMID:14523239</ref> <ref>PMID:12764195</ref> <ref>PMID:14630912</ref> <ref>PMID:15173182</ref> <ref>PMID:21076423</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Arnold WR]]
		+	[[Category: Cheng Y]]
		+	[[Category: Julius D]]

OCA at 12:20, 18 October 2023

OCA — Wed, 18 Oct 2023 12:20:12 GMT

←Older revision		Revision as of 12:20, 18 October 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8u2z is ON HOLD	+	The entry 8u2z is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8u2z" [edit=sysop:move=sysop]

OCA — Wed, 20 Sep 2023 12:38:01 GMT

Protected "8u2z" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:38, 20 September 2023

OCA: New page: '''Unreleased structure''' The entry 8u2z is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Sep 2023 12:38:00 GMT

New page: '''Unreleased structure''' The entry 8u2z is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8u2z is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8u2z - Revision history

OCA at 08:37, 9 May 2024

OCA at 12:20, 18 October 2023

OCA: Protected "8u2z" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8u2z is ON HOLD Authors: Description: Category: Unreleased Structures