OCA at 13:19, 13 March 2024

OCA — Wed, 13 Mar 2024 13:19:38 GMT

←Older revision		Revision as of 13:19, 13 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8u4q is ~~ON HOLD until Paper Publication~~	+	==Structure of REGN7663 Fab-bound CXCR4/Gi complex==
-		+	<StructureSection load='8u4q' size='340' side='right'caption='[[8u4q]], [[Resolution\|resolution]] 3.36Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8u4q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U4Q FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.36Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u4q OCA], [https://pdbe.org/8u4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u4q RCSB], [https://www.ebi.ac.uk/pdbsum/8u4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u4q ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CXCR4_HUMAN CXCR4_HUMAN] Defects in CXCR4 are a cause of WHIM syndrome (WHIM) [MIM:[https://omim.org/entry/193670 193670]; also known as warts, hypogammaglobulinemia, infections and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.<ref>PMID:12692554</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CXCR4_HUMAN CXCR4_HUMAN] Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.<ref>PMID:8329116</ref> <ref>PMID:8234909</ref> <ref>PMID:8629022</ref> <ref>PMID:8752280</ref> <ref>PMID:8752281</ref> <ref>PMID:10074102</ref> <ref>PMID:10644702</ref> <ref>PMID:10825158</ref> <ref>PMID:17197449</ref> <ref>PMID:20048153</ref> <ref>PMID:20228059</ref> <ref>PMID:20505072</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Franklin MC]]
		+	[[Category: McGoldrick LL]]
		+	[[Category: Saotome K]]

OCA at 12:20, 18 October 2023

OCA — Wed, 18 Oct 2023 12:20:57 GMT

←Older revision		Revision as of 12:20, 18 October 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8u4q is ON HOLD	+	The entry 8u4q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8u4q" [edit=sysop:move=sysop]

OCA — Wed, 20 Sep 2023 12:42:08 GMT

Protected "8u4q" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:42, 20 September 2023

OCA: New page: '''Unreleased structure''' The entry 8u4q is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Sep 2023 12:42:07 GMT

New page: '''Unreleased structure''' The entry 8u4q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8u4q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8u4q - Revision history

OCA at 13:19, 13 March 2024

OCA at 12:20, 18 October 2023

OCA: Protected "8u4q" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8u4q is ON HOLD Authors: Description: Category: Unreleased Structures