OCA at 12:10, 6 March 2024

OCA — Wed, 06 Mar 2024 12:10:38 GMT

←Older revision		Revision as of 12:10, 6 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~8u8f~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==GPR3 Orphan G-coupled Protein Receptor in complex with Dominant Negative Gs.==
-		+	<StructureSection load='8u8f' size='340' side='right'caption='[[8u8f]], [[Resolution\|resolution]] 3.49Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8u8f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8U8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8U8F FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.49Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8u8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8u8f OCA], [https://pdbe.org/8u8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8u8f RCSB], [https://www.ebi.ac.uk/pdbsum/8u8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8u8f ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Belousoff MJ]]
		+	[[Category: Russell IC]]
		+	[[Category: Sexton P]]

OCA: Protected "8u8f" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2023 05:10:28 GMT

Protected "8u8f" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:10, 27 September 2023

OCA: New page: '''Unreleased structure''' The entry 8u8f is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2023 05:10:26 GMT

New page: '''Unreleased structure''' The entry 8u8f is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8u8f is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8u8f - Revision history

OCA at 12:10, 6 March 2024

OCA: Protected "8u8f" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8u8f is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures