OCA at 12:11, 6 March 2024

OCA — Wed, 06 Mar 2024 12:11:07 GMT

←Older revision		Revision as of 12:11, 6 March 2024
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-	'''Unreleased structure'''

-	The entry ~~8uny~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N)==
-		+	<StructureSection load='8uny' size='340' side='right'caption='[[8uny]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8uny]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UNY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G1I:(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol'>G1I</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uny OCA], [https://pdbe.org/8uny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uny RCSB], [https://www.ebi.ac.uk/pdbsum/8uny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uny ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Pseudopseudohypoparathyroidism;Pseudohypoparathyroidism type 1A;Progressive osseous heteroplasia;Polyostotic fibrous dysplasia;Monostotic fibrous dysplasia;Pseudohypoparathyroidism type 1C;Pseudohypoparathyroidism type 1B;McCune-Albright syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Most affected individuals have defects in methylation of the gene. In some cases microdeletions involving the STX16 appear to cause loss of methylation at exon A/B of GNAS, resulting in PHP1B. Paternal uniparental isodisomy have also been observed. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Papasergi-Scott MM]]
		+	[[Category: Skiniotis G]]

OCA at 07:40, 29 November 2023

OCA — Wed, 29 Nov 2023 07:40:27 GMT

←Older revision		Revision as of 07:40, 29 November 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8uny is ON HOLD	+	The entry 8uny is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8uny" [edit=sysop:move=sysop]

OCA — Wed, 25 Oct 2023 06:03:50 GMT

Protected "8uny" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 25 October 2023

OCA: New page: '''Unreleased structure''' The entry 8uny is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Oct 2023 06:03:49 GMT

New page: '''Unreleased structure''' The entry 8uny is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8uny is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8uny - Revision history

OCA at 12:11, 6 March 2024

OCA at 07:40, 29 November 2023

OCA: Protected "8uny" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8uny is ON HOLD Authors: Description: Category: Unreleased Structures