8uq2 - Revision history

OCA: Replacing page with ''''Unreleased structure''' The entry 8uq2 is ON HOLD Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the subprimed state [[Category: Unrel...'

OCA — Wed, 22 Nov 2023 05:57:52 GMT

Replacing page with ''''Unreleased structure''' The entry 8uq2 is ON HOLD Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the subprimed state [[Category: Unrel...'

←Older revision		Revision as of 05:57, 22 November 2023
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		+	'''Unreleased structure'''

-	~~==Structure of human RyR2-S2808D in the subprimed state==~~	+	The entry 8uq2 is ON HOLD
-	~~<StructureSection load='~~8uq2~~' size='340' side='right'caption='[[8uq2]], [[Resolution\|resolution]] 2.98Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+	Authors: Miotto, M.C., Marks, A.R.
-	~~<table><tr><td colspan='2'>[[8uq2]]~~ is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ2 FirstGlance]. <br>	+
-	~~</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.98Å</td></tr>~~	+	Description: Structure of human RyR2-S2808D in the subprimed state
-	~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands~~:~~]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	[[Category: Unreleased Structures]]
-	~~<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia~~.~~org/fgij/fg~~.~~htm?mol=8uq2 FirstGlance]~~, ~~[http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq2 OCA]~~, ~~[https://pdbe~~.~~org/8uq2 PDBe], [https://www~~.~~rcsb.org/pdb/explore.do?structureId=8uq2 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq2 ProSAT]</span></td></tr>~~	+	[[Category: Miotto, M.C]]
-	~~</table>~~	+	[[Category: Marks, A.R]]
-	~~== Disease ==~~	+
-	~~[https~~://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+
-	~~== Function ==~~	+
-	~~[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release~~ of ~~Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role~~ in ~~triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of~~ the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	[[Category: ~~Homo sapiens~~]]	+
-	[[Category: ~~Large Structures~~]]	+
-	[[Category: Marks ~~AR]]~~	+
-	~~[[Category: Miotto MC~~]]	+

OCA at 07:44, 15 November 2023

OCA — Wed, 15 Nov 2023 07:44:22 GMT

←Older revision		Revision as of 07:44, 15 November 2023
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-	'''Unreleased structure'''

-	~~The entry~~ 8uq2 is ~~ON HOLD~~	+	==Structure of human RyR2-S2808D in the subprimed state==
-		+	<StructureSection load='8uq2' size='340' side='right'caption='[[8uq2]], [[Resolution\|resolution]] 2.98Å' scene=''>
-	~~Authors~~: ~~Miotto~~, M.C., ~~Marks~~, A.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8uq2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ2 FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~human RyR2-S2808D~~ in the ~~subprimed state~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.98Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Miotto, M.C~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq2 OCA], [https://pdbe.org/8uq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uq2 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq2 ProSAT]</span></td></tr>
-	[[Category: Marks~~, A.R~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Marks AR]]
		+	[[Category: Miotto MC]]

OCA at 09:09, 8 November 2023

OCA — Wed, 08 Nov 2023 09:09:51 GMT

←Older revision		Revision as of 09:09, 8 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8uq2 is ON HOLD ~~until sometime in the future~~	+	The entry 8uq2 is ON HOLD

	Authors: Miotto, M.C., Marks, A.R.		Authors: Miotto, M.C., Marks, A.R.

OCA: Protected "8uq2" [edit=sysop:move=sysop]

OCA — Wed, 01 Nov 2023 11:02:08 GMT

Protected "8uq2" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 1 November 2023

OCA: New page: '''Unreleased structure''' The entry 8uq2 is ON HOLD until sometime in the future Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the subprimed state ...

OCA — Wed, 01 Nov 2023 11:02:05 GMT

New page: '''Unreleased structure''' The entry 8uq2 is ON HOLD until sometime in the future Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the subprimed state ...

New page

'''Unreleased structure'''

The entry 8uq2 is ON HOLD until sometime in the future

Authors: Miotto, M.C., Marks, A.R.

Description: Structure of human RyR2-S2808D in the subprimed state
[[Category: Unreleased Structures]]
[[Category: Miotto, M.C]]
[[Category: Marks, A.R]]