8uq5 - Revision history

OCA at 05:57, 22 November 2023

OCA — Wed, 22 Nov 2023 05:57:59 GMT

←Older revision		Revision as of 05:57, 22 November 2023
Line 1:		Line 1:
		+	'''Unreleased structure'''

-	~~==Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin==~~	+	The entry 8uq5 is ON HOLD until sometime in the future
-	~~<StructureSection load='~~8uq5~~' size='340' side='right'caption='[[8uq5]], [[Resolution\|resolution]] 3.96Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+	Authors: Miotto, M.C., Marks, A.R.
-	~~<table><tr><td colspan='2'>[[8uq5]]~~ is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ5 OCA]. For a <b>guided tour on the ~~structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ5 FirstGlance]. <br>~~	+
-	~~</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.96Å</td></tr>~~	+	Description: Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin
-	~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands~~:~~]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	[[Category: Unreleased Structures]]
-	~~<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia~~.~~org/fgij/fg~~.~~htm?mol=8uq5 FirstGlance]~~, ~~[http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq5 OCA]~~, ~~[https://pdbe~~.~~org/8uq5 PDBe], [https://www~~.~~rcsb.org/pdb/explore.do?structureId=8uq5 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq5 ProSAT]</span></td></tr>~~	+	[[Category: Miotto, M.C]]
-	~~</table>~~	+	[[Category: Marks, A.R]]
-	~~== Disease ==~~	+
-	~~[https~~://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in ~~this entry. The disease is caused by mutations affecting~~ the ~~gene represented~~ in ~~this entry.~~	+
-	~~== Function ==~~	+
-	~~[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates~~ the ~~release~~ of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	[[Category: ~~Homo sapiens~~]]	+
-	[[Category: ~~Large Structures~~]]	+
-	[[Category: Marks ~~AR]]~~	+
-	~~[[Category: Miotto MC~~]]	+

OCA at 07:44, 15 November 2023

OCA — Wed, 15 Nov 2023 07:44:39 GMT

←Older revision		Revision as of 07:44, 15 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8uq5 is ~~ON HOLD until sometime in~~ the ~~future~~	+	==Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin==
-		+	<StructureSection load='8uq5' size='340' side='right'caption='[[8uq5]], [[Resolution\|resolution]] 3.96Å' scene=''>
-	~~Authors~~: ~~Miotto~~, M.C., ~~Marks~~, A.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8uq5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UQ5 FirstGlance]. <br>
-	~~Description~~: ~~Structure of human RyR2-S2808D~~ in the ~~primed state~~ in the ~~presence~~ of ~~Rapamycin~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.96Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Miotto, M.C~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uq5 OCA], [https://pdbe.org/8uq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uq5 RCSB], [https://www.ebi.ac.uk/pdbsum/8uq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uq5 ProSAT]</span></td></tr>
-	[[Category: Marks~~, A.R~~]]	+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Familial isolated arrhythmogenic ventricular dysplasia, right dominant form;Catecholaminergic polymorphic ventricular tachycardia;Familial isolated arrhythmogenic ventricular dysplasia, biventricular form;Familial isolated arrhythmogenic ventricular dysplasia, left dominant form. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RYR2_HUMAN RYR2_HUMAN] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10830164</ref> <ref>PMID:20056922</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Marks AR]]
		+	[[Category: Miotto MC]]

OCA: Protected "8uq5" [edit=sysop:move=sysop]

OCA — Wed, 01 Nov 2023 11:02:25 GMT

Protected "8uq5" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:02, 1 November 2023

OCA: New page: '''Unreleased structure''' The entry 8uq5 is ON HOLD until sometime in the future Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the primed state in ...

OCA — Wed, 01 Nov 2023 11:02:24 GMT

New page: '''Unreleased structure''' The entry 8uq5 is ON HOLD until sometime in the future Authors: Miotto, M.C., Marks, A.R. Description: Structure of human RyR2-S2808D in the primed state in ...

New page

'''Unreleased structure'''

The entry 8uq5 is ON HOLD until sometime in the future

Authors: Miotto, M.C., Marks, A.R.

Description: Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin
[[Category: Unreleased Structures]]
[[Category: Miotto, M.C]]
[[Category: Marks, A.R]]