OCA at 08:38, 9 May 2024

OCA — Thu, 09 May 2024 08:38:11 GMT

←Older revision		Revision as of 08:38, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ut7 is ~~ON HOLD until Paper~~ Publication	+	==CryoEM structure of A/Perth/16/2009 H3 in complex with polyclonal Fab from mice immunized with H3 stem nanoparticles-28 days post immunization==
		+	<StructureSection load='8ut7' size='340' side='right'caption='[[8ut7]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8ut7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UT7 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ut7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ut7 OCA], [https://pdbe.org/8ut7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ut7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ut7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ut7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C6KNH7_9INFA C6KNH7_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS001364_004_327643]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer cases, intergroup protective bnAbs can be generated by human antibody paratopes that accommodate the conserved glycan differences between the group 1 and group 2 stems. We applied germline-engaging nanoparticle immunogens to elicit a class of cross-group bnAbs from physiological precursor frequency within a humanized mouse model. Cross-group protection depended on the presence of the human bnAb precursors within the B cell repertoire, and the vaccine-expanded antibodies enriched for an N55T substitution in the CDRH2 loop, a hallmark of the bnAb class. Structurally, this single mutation introduced a flexible fulcrum to accommodate glycosylation differences and could alone enable cross-group protection. Thus, broad IAV immunity can be expanded from the germline repertoire via minimal antigenic input and an exceptionally simple antibody development pathway.

-	~~Authors~~:	+	Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.,Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D Immunity. 2024 Apr 18:S1074-7613(24)00143-2. doi: 10.1016/j.immuni.2024.03.022. PMID:38670113<ref>PMID:38670113</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8ut7" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Influenza A virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Han J]]
		+	[[Category: Huang J]]
		+	[[Category: Ward AB]]

OCA at 07:03, 6 December 2023

OCA — Wed, 06 Dec 2023 07:03:07 GMT

←Older revision		Revision as of 07:03, 6 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ut7 is ON HOLD	+	The entry 8ut7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ut7" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2023 09:15:57 GMT

Protected "8ut7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 8 November 2023

OCA: New page: '''Unreleased structure''' The entry 8ut7 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Nov 2023 09:15:54 GMT

New page: '''Unreleased structure''' The entry 8ut7 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ut7 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ut7 - Revision history

OCA at 08:38, 9 May 2024

OCA at 07:03, 6 December 2023

OCA: Protected "8ut7" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ut7 is ON HOLD Authors: Description: Category: Unreleased Structures