OCA at 08:38, 9 May 2024

OCA — Thu, 09 May 2024 08:38:16 GMT

←Older revision		Revision as of 08:38, 9 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ut9 is ~~ON HOLD until Paper~~ Publication	+	==CryoEM structure of A/Shanghai/1/2013 H7 in complex with polyclonal Fab from mice immunized with H7 stem nanoparticles-28 days post immunization==
		+	<StructureSection load='8ut9' size='340' side='right'caption='[[8ut9]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8ut9]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UT9 FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ut9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ut9 OCA], [https://pdbe.org/8ut9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ut9 RCSB], [https://www.ebi.ac.uk/pdbsum/8ut9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ut9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/V5IRV0_9INFA V5IRV0_9INFA]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin (HA) stem of influenza A viruses (IAVs) tend to be effective against either group 1 or group 2 viral diversity. In rarer cases, intergroup protective bnAbs can be generated by human antibody paratopes that accommodate the conserved glycan differences between the group 1 and group 2 stems. We applied germline-engaging nanoparticle immunogens to elicit a class of cross-group bnAbs from physiological precursor frequency within a humanized mouse model. Cross-group protection depended on the presence of the human bnAb precursors within the B cell repertoire, and the vaccine-expanded antibodies enriched for an N55T substitution in the CDRH2 loop, a hallmark of the bnAb class. Structurally, this single mutation introduced a flexible fulcrum to accommodate glycosylation differences and could alone enable cross-group protection. Thus, broad IAV immunity can be expanded from the germline repertoire via minimal antigenic input and an exceptionally simple antibody development pathway.

-	~~Authors~~:	+	Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses.,Ray R, Nait Mohamed FA, Maurer DP, Huang J, Alpay BA, Ronsard L, Xie Z, Han J, Fernandez-Quintero M, Phan QA, Ursin RL, Vu M, Kirsch KH, Prum T, Rosado VC, Bracamonte-Moreno T, Okonkwo V, Bals J, McCarthy C, Nair U, Kanekiyo M, Ward AB, Schmidt AG, Batista FD, Lingwood D Immunity. 2024 Apr 18:S1074-7613(24)00143-2. doi: 10.1016/j.immuni.2024.03.022. PMID:38670113<ref>PMID:38670113</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8ut9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Influenza A virus]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Han J]]
		+	[[Category: Huang J]]
		+	[[Category: Ward AB]]

OCA at 07:03, 6 December 2023

OCA — Wed, 06 Dec 2023 07:03:11 GMT

←Older revision		Revision as of 07:03, 6 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8ut9 is ON HOLD	+	The entry 8ut9 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8ut9" [edit=sysop:move=sysop]

OCA — Wed, 08 Nov 2023 09:16:08 GMT

Protected "8ut9" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:16, 8 November 2023

OCA: New page: '''Unreleased structure''' The entry 8ut9 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 08 Nov 2023 09:16:06 GMT

New page: '''Unreleased structure''' The entry 8ut9 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8ut9 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8ut9 - Revision history

OCA at 08:38, 9 May 2024

OCA at 07:03, 6 December 2023

OCA: Protected "8ut9" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ut9 is ON HOLD Authors: Description: Category: Unreleased Structures