OCA at 05:30, 17 April 2024

OCA — Wed, 17 Apr 2024 05:30:50 GMT

←Older revision		Revision as of 05:30, 17 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8v6l is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Open-state cryo-EM structure of human TRPV3 in presence of tetrahydrocannabivarin (THCV) in cNW30 nanodiscs==
-		+	<StructureSection load='8v6l' size='340' side='right'caption='[[8v6l]], [[Resolution\|resolution]] 3.68Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8v6l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V6L FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.68Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I8E:Tetrahydrocannabivarin'>I8E</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v6l OCA], [https://pdbe.org/8v6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v6l RCSB], [https://www.ebi.ac.uk/pdbsum/8v6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v6l ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Nadezhdin KD]]
		+	[[Category: Neuberger A]]
		+	[[Category: Sobolevsky AI]]

OCA at 08:57, 20 December 2023

OCA — Wed, 20 Dec 2023 08:57:06 GMT

←Older revision		Revision as of 08:57, 20 December 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8v6l is ON HOLD	+	The entry 8v6l is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8v6l" [edit=sysop:move=sysop]

OCA — Wed, 13 Dec 2023 10:09:33 GMT

Protected "8v6l" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:09, 13 December 2023

OCA: New page: '''Unreleased structure''' The entry 8v6l is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Dec 2023 10:09:32 GMT

New page: '''Unreleased structure''' The entry 8v6l is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8v6l is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8v6l - Revision history

OCA at 05:30, 17 April 2024

OCA at 08:57, 20 December 2023

OCA: Protected "8v6l" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8v6l is ON HOLD Authors: Description: Category: Unreleased Structures