OCA at 07:23, 14 February 2024

OCA — Wed, 14 Feb 2024 07:23:05 GMT

←Older revision		Revision as of 07:23, 14 February 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8vkk ~~is ON HOLD~~	+	==Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein==
-		+	<StructureSection load='8vkk' size='340' side='right'caption='[[8vkk]], [[Resolution\|resolution]] 2.81Å' scene=''>
-	~~Authors~~: ~~Zhu, X~~., ~~Mannar,~~ D.~~, Saville, J~~., ~~Poloni, C~~.~~, Bezeruk, A~~.~~, Tidey, K~~., ~~Ahmed, S~~., ~~Tuttle, K~~., ~~Vahdatihassani, F~~., ~~Cholak, S~~., ~~Cook, L~~., ~~Steiner~~, T.S., ~~Subramaniam~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8vkk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VKK FirstGlance]. <br>
-	~~Description: Cryo~~-~~EM structure~~ of ~~SARS~~-~~CoV~~-~~2 XBB~~.1.~~5 spike protein~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.81Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Cook, L~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vkk OCA], [https://pdbe.org/8vkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vkk RCSB], [https://www.ebi.ac.uk/pdbsum/8vkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vkk ProSAT]</span></td></tr>
-	[[Category: ~~Subramaniam,~~ S]]	+	</table>
-	[[Category: ~~Saville, J~~]]	+	== Function ==
-	[[Category: ~~Ahmed,~~ S]]	+	[https://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref> mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
-	[[Category: ~~Tidey, K~~]]	+	== References ==
-	[[Category: ~~Tuttle, K~~]]	+	<references/>
-	[[Category: ~~Steiner, T.S~~]]	+	__TOC__
-	[[Category: ~~Poloni, C~~]]	+	</StructureSection>
-	[[Category: ~~Zhu, X~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Cholak,~~ S]]	+	[[Category: Severe acute respiratory syndrome coronavirus 2]]
-	[[Category: ~~Vahdatihassani, F~~]]	+	[[Category: Ahmed S]]
-	[[Category: ~~Bezeruk, A~~]]	+	[[Category: Bezeruk A]]
-	[[Category: ~~Mannar, D~~]]	+	[[Category: Cholak S]]
		+	[[Category: Cook L]]
		+	[[Category: Mannar D]]
		+	[[Category: Poloni C]]
		+	[[Category: Saville J]]
		+	[[Category: Steiner TS]]
		+	[[Category: Subramaniam S]]
		+	[[Category: Tidey K]]
		+	[[Category: Tuttle K]]
		+	[[Category: Vahdatihassani F]]
		+	[[Category: Zhu X]]

OCA: Protected "8vkk" [edit=sysop:move=sysop]

OCA — Wed, 17 Jan 2024 09:05:04 GMT

Protected "8vkk" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:05, 17 January 2024

OCA: New page: '''Unreleased structure''' The entry 8vkk is ON HOLD Authors: Zhu, X., Mannar, D., Saville, J., Poloni, C., Bezeruk, A., Tidey, K., Ahmed, S., Tuttle, K., Vahdatihassani, F., Cholak, S....

OCA — Wed, 17 Jan 2024 09:05:03 GMT

New page: '''Unreleased structure''' The entry 8vkk is ON HOLD Authors: Zhu, X., Mannar, D., Saville, J., Poloni, C., Bezeruk, A., Tidey, K., Ahmed, S., Tuttle, K., Vahdatihassani, F., Cholak, S....

New page

'''Unreleased structure'''

The entry 8vkk is ON HOLD

Authors: Zhu, X., Mannar, D., Saville, J., Poloni, C., Bezeruk, A., Tidey, K., Ahmed, S., Tuttle, K., Vahdatihassani, F., Cholak, S., Cook, L., Steiner, T.S., Subramaniam, S.

Description: Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein
[[Category: Unreleased Structures]]
[[Category: Cook, L]]
[[Category: Subramaniam, S]]
[[Category: Saville, J]]
[[Category: Ahmed, S]]
[[Category: Tidey, K]]
[[Category: Tuttle, K]]
[[Category: Steiner, T.S]]
[[Category: Poloni, C]]
[[Category: Zhu, X]]
[[Category: Cholak, S]]
[[Category: Vahdatihassani, F]]
[[Category: Bezeruk, A]]
[[Category: Mannar, D]]

8vkk - Revision history

OCA at 07:23, 14 February 2024

OCA: Protected "8vkk" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8vkk is ON HOLD Authors: Zhu, X., Mannar, D., Saville, J., Poloni, C., Bezeruk, A., Tidey, K., Ahmed, S., Tuttle, K., Vahdatihassani, F., Cholak, S....