OCA at 05:31, 17 April 2024

OCA — Wed, 17 Apr 2024 05:31:04 GMT

←Older revision		Revision as of 05:31, 17 April 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8w2l is ~~ON HOLD until Paper Publication~~	+	==TRPM7 structure in complex with anticancer agent CCT128930 in closed state==
-		+	<StructureSection load='8w2l' size='340' side='right'caption='[[8w2l]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8w2l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W2L FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DU0:2-[2-[(1~{S},2~{S},4~{S},5~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2-oxane]-16-yl]oxyethyl]propane-1,3-diol'>DU0</scene>, <scene name='pdbligand=M05:4-(4-CHLOROBENZYL)-1-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PIPERIDIN-4-AMINIUM'>M05</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w2l OCA], [https://pdbe.org/8w2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w2l RCSB], [https://www.ebi.ac.uk/pdbsum/8w2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w2l ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TRPM7_MOUSE TRPM7_MOUSE] Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).<ref>PMID:11385574</ref> [https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aequorea victoria]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Nadezhdin KD]]
		+	[[Category: Sobolevsky AI]]

OCA at 10:35, 6 March 2024

OCA — Wed, 06 Mar 2024 10:35:37 GMT

←Older revision		Revision as of 10:35, 6 March 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8w2l is ON HOLD	+	The entry 8w2l is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8w2l" [edit=sysop:move=sysop]

OCA — Fri, 01 Mar 2024 08:15:53 GMT

Protected "8w2l" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 1 March 2024

OCA: New page: '''Unreleased structure''' The entry 8w2l is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 01 Mar 2024 08:15:52 GMT

New page: '''Unreleased structure''' The entry 8w2l is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8w2l is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8w2l - Revision history

OCA at 05:31, 17 April 2024

OCA at 10:35, 6 March 2024

OCA: Protected "8w2l" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8w2l is ON HOLD Authors: Description: Category: Unreleased Structures