OCA at 12:10, 8 November 2023

OCA — Wed, 08 Nov 2023 12:10:20 GMT

←Older revision		Revision as of 12:10, 8 November 2023
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~8w83~~ is ~~ON HOLD~~ until ~~2025~~-08-31	+	==HLA-DQ2.5-alpha1 gliadin peptide in complex with DQN0344AE02==
-		+	<StructureSection load='8w83' size='340' side='right'caption='[[8w83]], [[Resolution\|resolution]] 2.82Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8w83]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W83 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.818Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w83 OCA], [https://pdbe.org/8w83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w83 RCSB], [https://www.ebi.ac.uk/pdbsum/8w83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w83 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DQA1_HUMAN DQA1_HUMAN] Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Fukami TA]]
		+	[[Category: Irie M]]
		+	[[Category: Ishii S]]
		+	[[Category: Okura Y]]
		+	[[Category: Takahashi N]]
		+	[[Category: Teranishi-Ikawa Y]]
		+	[[Category: Torizawa T]]
		+	[[Category: Tsushima T]]

OCA at 11:09, 1 November 2023

OCA — Wed, 01 Nov 2023 11:09:19 GMT

←Older revision		Revision as of 11:09, 1 November 2023
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8w83 is ON HOLD	+	The entry 8w83 is ON HOLD until 2025-08-31

	Authors:		Authors:

OCA: Protected "8w83" [edit=sysop:move=sysop]

OCA — Wed, 06 Sep 2023 05:00:30 GMT

Protected "8w83" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:00, 6 September 2023

OCA: New page: '''Unreleased structure''' The entry 8w83 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Sep 2023 05:00:27 GMT

New page: '''Unreleased structure''' The entry 8w83 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8w83 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8w83 - Revision history

OCA at 12:10, 8 November 2023

OCA at 11:09, 1 November 2023

OCA: Protected "8w83" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8w83 is ON HOLD Authors: Description: Category: Unreleased Structures