OCA at 09:41, 1 March 2024

OCA — Fri, 01 Mar 2024 09:41:00 GMT

←Older revision		Revision as of 09:41, 1 March 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 8w9w is ~~ON HOLD until Paper Publication~~	+	==The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine==
-		+	<StructureSection load='8w9w' size='340' side='right'caption='[[8w9w]], [[Resolution\|resolution]] 3.74Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8w9w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W9W FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.74Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=UJO:~{N}-[(~{Z},2~{S},3~{R})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide'>UJO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w9w OCA], [https://pdbe.org/8w9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w9w RCSB], [https://www.ebi.ac.uk/pdbsum/8w9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w9w ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SAMD8_HUMAN SAMD8_HUMAN] Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.<ref>PMID:19506037</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Cao Y]]
		+	[[Category: Chen Y]]
		+	[[Category: Hu K]]
		+	[[Category: Yao D]]
		+	[[Category: Zhang Q]]
		+	[[Category: Zhou L]]

OCA: Protected "8w9w" [edit=sysop:move=sysop]

OCA — Wed, 20 Sep 2023 12:57:42 GMT

Protected "8w9w" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:57, 20 September 2023

OCA: New page: '''Unreleased structure''' The entry 8w9w is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 20 Sep 2023 12:57:40 GMT

New page: '''Unreleased structure''' The entry 8w9w is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8w9w is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

8w9w - Revision history

OCA at 09:41, 1 March 2024

OCA: Protected "8w9w" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8w9w is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures