OCA at 10:11, 17 January 2024

OCA — Wed, 17 Jan 2024 10:11:36 GMT

←Older revision		Revision as of 10:11, 17 January 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8wdt is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)==
		+	<StructureSection load='8wdt' size='340' side='right'caption='[[8wdt]], [[Resolution\|resolution]] 3.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[8wdt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WDT FirstGlance]. <br>
		+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.34Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WCH:(2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide'>WCH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wdt OCA], [https://pdbe.org/8wdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wdt RCSB], [https://www.ebi.ac.uk/pdbsum/8wdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wdt ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rational synthetic expansion of photoresponsive ligands is important for photopharmacological studies. Adenosine A(2A) receptor (A(2A)R) is stimulated by adenosine and related in Parkinson's disease and other diseases. Here, we report the crystal structure of the A(2A)R in complex with the novel photoresponsive ligand photoNECA (blue) at 3.34 A resolution. PhotoNECA (blue) was designed for this structural study and the cell-based assay showed a photoresponsive and receptor selective characteristics of photoNECA (blue) for A(2A)R. The crystal structure explains the binding mode, photoresponsive mechanism and receptor selectivity of photoNECA (blue). Our study would promote not only the rational design of photoresponsive ligands but also dynamic structural studies of A(2A)R.

-	~~Authors~~:	+	Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A(2A) receptor.,Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, Yamamoto M, Im D, Asada H, Kiyonaka S, Iwata S Biochem Biophys Res Commun. 2023 Dec 20;695:149393. doi: , 10.1016/j.bbrc.2023.149393. PMID:38171234<ref>PMID:38171234</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 8wdt" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Mus musculus]]
		+	[[Category: Araya T]]
		+	[[Category: Asada H]]
		+	[[Category: Im DH]]
		+	[[Category: Iwata S]]

OCA at 12:38, 18 October 2023

OCA — Wed, 18 Oct 2023 12:38:50 GMT

←Older revision		Revision as of 12:38, 18 October 2023
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8wdt is ON HOLD	+	The entry 8wdt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8wdt" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2023 05:23:52 GMT

Protected "8wdt" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 27 September 2023

OCA: New page: '''Unreleased structure''' The entry 8wdt is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2023 05:23:51 GMT

New page: '''Unreleased structure''' The entry 8wdt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8wdt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8wdt - Revision history

OCA at 10:11, 17 January 2024

OCA at 12:38, 18 October 2023

OCA: Protected "8wdt" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8wdt is ON HOLD Authors: Description: Category: Unreleased Structures