OCA at 10:15, 27 March 2024

OCA — Wed, 27 Mar 2024 10:15:04 GMT

←Older revision		Revision as of 10:15, 27 March 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8xlq is ~~ON HOLD until Paper Publication~~	+	==FGFR4 kinase domain with a dual-warhead covalent inhibitor CXF-007==
-		+	<StructureSection load='8xlq' size='340' side='right'caption='[[8xlq]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8xlq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XLQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LVQ:CXF007'>A1LVQ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xlq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xlq OCA], [https://pdbe.org/8xlq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xlq RCSB], [https://www.ebi.ac.uk/pdbsum/8xlq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xlq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FGFR4_HUMAN FGFR4_HUMAN] Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.<ref>PMID:7680645</ref> <ref>PMID:7518429</ref> <ref>PMID:8663044</ref> <ref>PMID:11433297</ref> <ref>PMID:16597617</ref> <ref>PMID:17623664</ref> <ref>PMID:17311277</ref> <ref>PMID:18480409</ref> <ref>PMID:18670643</ref> <ref>PMID:20683963</ref> <ref>PMID:20018895</ref> <ref>PMID:20798051</ref> <ref>PMID:21653700</ref> <ref>PMID:20876804</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Chen XJ]]
		+	[[Category: Chen YH]]

OCA at 10:46, 1 February 2024

OCA — Thu, 01 Feb 2024 10:46:36 GMT

←Older revision		Revision as of 10:46, 1 February 2024
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 8xlq is ON HOLD	+	The entry 8xlq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "8xlq" [edit=sysop:move=sysop]

OCA — Wed, 03 Jan 2024 10:16:31 GMT

Protected "8xlq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:16, 3 January 2024

OCA: New page: '''Unreleased structure''' The entry 8xlq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 03 Jan 2024 10:16:30 GMT

New page: '''Unreleased structure''' The entry 8xlq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 8xlq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]

8xlq - Revision history

OCA at 10:15, 27 March 2024

OCA at 10:46, 1 February 2024

OCA: Protected "8xlq" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8xlq is ON HOLD Authors: Description: Category: Unreleased Structures