OCA at 07:24, 14 February 2024

OCA — Wed, 14 Feb 2024 07:24:12 GMT

←Older revision		Revision as of 07:24, 14 February 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 8y4z is ~~ON HOLD~~	+	==Monomeric HERC5 HECT c-lobe structure in solution==
-		+	<StructureSection load='8y4z' size='340' side='right'caption='[[8y4z]]' scene=''>
-	~~Authors~~: ~~Dag~~, C., ~~Lambert~~, M., ~~Kahraman~~, K., ~~Lohn~~, F., ~~Lee~~, W., ~~Gocenler~~, O., ~~Guntert~~, P., ~~Dotsch~~, V.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8y4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y4Z FirstGlance]. <br>
-	~~Description~~: ~~Monomeric HERC5 HECT c-lobe structure in solution~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y4z OCA], [https://pdbe.org/8y4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y4z RCSB], [https://www.ebi.ac.uk/pdbsum/8y4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y4z ProSAT]</span></td></tr>
-	[[Category: ~~Guntert, P~~]]	+	</table>
-	[[Category: ~~Gocenler, O~~]]	+	== Function ==
-	[[Category: ~~Kahraman, K~~]]	+	[https://www.uniprot.org/uniprot/HERC5_HUMAN HERC5_HUMAN] Major E3 ligase for ISG15 conjugation (PubMed:26355087, PubMed:27564865, PubMed:27534820, PubMed:34572049, PubMed:37279284). Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Mediates ISGylation of the phosphatase PTEN leading to its degradation, thus alleviating its suppression of the PI3K-AKT signaling pathway and promoting the production of cytokines that facilitate bacterial clearance (PubMed:37279284). Interferes with the function of key viral structural proteins such as ebolavirus structural protein VP40 or HIV-1 protein GAG (PubMed:22093708, PubMed:34572049). Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. Promotes parkin/PRKN ubiquitin E3 ligase activity by suppressing the intramolecular interaction that maintains its autoinhibited conformation (PubMed:27534820).<ref>PMID:16407192</ref> <ref>PMID:16815975</ref> <ref>PMID:16884686</ref> <ref>PMID:20133869</ref> <ref>PMID:20308324</ref> <ref>PMID:20385878</ref> <ref>PMID:20542004</ref> <ref>PMID:22093708</ref> <ref>PMID:26355087</ref> <ref>PMID:27534820</ref> <ref>PMID:27564865</ref> <ref>PMID:34572049</ref> <ref>PMID:37279284</ref> (Microbial infection) Functions as an E3 ligase for ISGylation of hepatitis B virus protein X leading to enhanced viral replication due to increased interferon resistance.<ref>PMID:34661519</ref>
-	[[Category: ~~Lee, W~~]]	+	== References ==
-	[[Category: ~~Dotsch, V~~]]	+	<references/>
-	[[Category: Lambert, M]]	+	__TOC__
-	[[Category: ~~Lohn, F~~]]	+	</StructureSection>
-	[[Category: ~~Dag, C~~]]	+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Dag C]]
		+	[[Category: Dotsch V]]
		+	[[Category: Gocenler O]]
		+	[[Category: Guntert P]]
		+	[[Category: Kahraman K]]
		+	[[Category: Lambert M]]
		+	[[Category: Lee W]]
		+	[[Category: Lohn F]]

OCA: Protected "8y4z" [edit=sysop:move=sysop]

OCA — Wed, 07 Feb 2024 05:32:10 GMT

Protected "8y4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 7 February 2024

OCA: New page: '''Unreleased structure''' The entry 8y4z is ON HOLD Authors: Dag, C., Lambert, M., Kahraman, K., Lohn, F., Lee, W., Gocenler, O., Guntert, P., Dotsch, V. Description: Monomeric HERC5 ...

OCA — Wed, 07 Feb 2024 05:32:09 GMT

New page: '''Unreleased structure''' The entry 8y4z is ON HOLD Authors: Dag, C., Lambert, M., Kahraman, K., Lohn, F., Lee, W., Gocenler, O., Guntert, P., Dotsch, V. Description: Monomeric HERC5 ...

New page

'''Unreleased structure'''

The entry 8y4z is ON HOLD

Authors: Dag, C., Lambert, M., Kahraman, K., Lohn, F., Lee, W., Gocenler, O., Guntert, P., Dotsch, V.

Description: Monomeric HERC5 HECT c-lobe structure in solution
[[Category: Unreleased Structures]]
[[Category: Guntert, P]]
[[Category: Gocenler, O]]
[[Category: Kahraman, K]]
[[Category: Lee, W]]
[[Category: Dotsch, V]]
[[Category: Lambert, M]]
[[Category: Lohn, F]]
[[Category: Dag, C]]

8y4z - Revision history

OCA at 07:24, 14 February 2024

OCA: Protected "8y4z" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8y4z is ON HOLD Authors: Dag, C., Lambert, M., Kahraman, K., Lohn, F., Lee, W., Gocenler, O., Guntert, P., Dotsch, V. Description: Monomeric HERC5 ...