OCA at 18:09, 29 May 2024

OCA — Wed, 29 May 2024 18:09:48 GMT

←Older revision		Revision as of 18:09, 29 May 2024
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-	'''Unreleased structure'''

-	~~The entry~~ 8ykx ~~is ON HOLD~~	+	==Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid==
-		+	<StructureSection load='8ykx' size='340' side='right'caption='[[8ykx]], [[Resolution\|resolution]] 2.69Å' scene=''>
-	~~Authors~~: Li, C., ~~Liu~~, H., Li, J., ~~Zhu~~, H., Fu, W., Xu, H.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[8ykx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YKX FirstGlance]. <br>
-	~~Description~~: ~~Cryo~~-~~EM structure~~ of succinate receptor ~~SUCR1 bound~~ to ~~maleic acid~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 2.69Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAE:MALEIC+ACID'>MAE</scene></td></tr>
-	[[Category: ~~Xu, H.E~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ykx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ykx OCA], [https://pdbe.org/8ykx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ykx RCSB], [https://www.ebi.ac.uk/pdbsum/8ykx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ykx ProSAT]</span></td></tr>
-	[[Category: ~~Li, C~~]]	+	</table>
-	[[Category: ~~Zhu, H~~]]	+	== Function ==
-	[[Category: ~~Li, J~~]]	+	[https://www.uniprot.org/uniprot/SUCR1_HUMAN SUCR1_HUMAN] G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:23770096, PubMed:34133934). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:34133934). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (By similarity). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involoved in immune function (PubMed:34133934). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (By similarity). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (By similarity). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (By similarity). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (By similarity). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity).[UniProtKB:Q6IYF9][UniProtKB:Q99MT6]<ref>PMID:15141213</ref> <ref>PMID:18820681</ref> <ref>PMID:23770096</ref> <ref>PMID:34133934</ref>
-	[[Category: Fu, W]]	+	== References ==
-	[[Category: Liu, H]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Rattus norvegicus]]
		+	[[Category: Synthetic construct]]
		+	[[Category: Fu W]]
		+	[[Category: Li C]]
		+	[[Category: Li J]]
		+	[[Category: Liu H]]
		+	[[Category: Xu HE]]
		+	[[Category: Zhu H]]

OCA: Protected "8ykx" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2024 12:19:41 GMT

Protected "8ykx" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:19, 13 March 2024

OCA: New page: '''Unreleased structure''' The entry 8ykx is ON HOLD Authors: Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. Description: Cryo-EM structure of succinate receptor SUCR1 bound to mal...

OCA — Wed, 13 Mar 2024 12:19:40 GMT

New page: '''Unreleased structure''' The entry 8ykx is ON HOLD Authors: Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. Description: Cryo-EM structure of succinate receptor SUCR1 bound to mal...

New page

'''Unreleased structure'''

The entry 8ykx is ON HOLD

Authors: Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E.

Description: Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
[[Category: Unreleased Structures]]
[[Category: Xu, H.E]]
[[Category: Li, C]]
[[Category: Zhu, H]]
[[Category: Li, J]]
[[Category: Fu, W]]
[[Category: Liu, H]]

8ykx - Revision history

OCA at 18:09, 29 May 2024

OCA: Protected "8ykx" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 8ykx is ON HOLD Authors: Li, C., Liu, H., Li, J., Zhu, H., Fu, W., Xu, H.E. Description: Cryo-EM structure of succinate receptor SUCR1 bound to mal...