OCA at 18:10, 29 May 2024

OCA — Wed, 29 May 2024 18:10:42 GMT

←Older revision		Revision as of 18:10, 29 May 2024
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 9bju is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5==
-		+	<StructureSection load='9bju' size='340' side='right'caption='[[9bju]], [[Resolution\|resolution]] 2.47Å' scene=''>
-	~~Authors~~: ~~Murray~~, J.M., Wu, H., ~~Fuhrmann~~, J., ~~Fairbrother, W~~.J., ~~DiPasquale~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[9bju]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BJU FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the complex ~~between~~ VHL, ~~ElonginB, ElonginC,~~ and ~~compound 5~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.47Å</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AQ4:4-phenyl-D-phenylalanine'>A1AQ4</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TBG:3-METHYL-L-VALINE'>TBG</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
-	[[Category: ~~Fairbrother, W.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bju OCA], [https://pdbe.org/9bju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bju RCSB], [https://www.ebi.ac.uk/pdbsum/9bju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bju ProSAT]</span></td></tr>
-	[[Category: ~~Murray, J.M~~]]	+	</table>
-	[[Category: ~~Dipasquale,~~ A]]	+	== Function ==
-	[[Category: Fuhrmann, J]]	+	[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
-	[[Category: Wu, H]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
		+	[[Category: Synthetic construct]]
		+	[[Category: DiPasquale A]]
		+	[[Category: Fairbrother WJ]]
		+	[[Category: Fuhrmann J]]
		+	[[Category: Murray JM]]
		+	[[Category: Wu H]]

OCA at 07:01, 22 May 2024

OCA — Wed, 22 May 2024 07:01:38 GMT

←Older revision		Revision as of 07:01, 22 May 2024
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 9bju is ON HOLD	+	The entry 9bju is ON HOLD until Paper Publication

	Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A.		Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A.
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Fairbrother, W.J]]		[[Category: Fairbrother, W.J]]
-	[[Category: Dipasquale, A]]
	[[Category: Murray, J.M]]		[[Category: Murray, J.M]]
		+	[[Category: Dipasquale, A]]
	[[Category: Fuhrmann, J]]		[[Category: Fuhrmann, J]]
	[[Category: Wu, H]]		[[Category: Wu, H]]

OCA: Protected "9bju" [edit=sysop:move=sysop]

OCA — Wed, 01 May 2024 05:20:05 GMT

Protected "9bju" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:20, 1 May 2024

OCA: New page: '''Unreleased structure''' The entry 9bju is ON HOLD Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A. Description: Crystal structure of the complex betwee...

OCA — Wed, 01 May 2024 05:20:04 GMT

New page: '''Unreleased structure''' The entry 9bju is ON HOLD Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A. Description: Crystal structure of the complex betwee...

New page

'''Unreleased structure'''

The entry 9bju is ON HOLD

Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A.

Description: Crystal structure of the complex between VHL, ElonginB, ElonginC, and compound 5
[[Category: Unreleased Structures]]
[[Category: Fairbrother, W.J]]
[[Category: Dipasquale, A]]
[[Category: Murray, J.M]]
[[Category: Fuhrmann, J]]
[[Category: Wu, H]]

9bju - Revision history

OCA at 18:10, 29 May 2024

OCA at 07:01, 22 May 2024

OCA: Protected "9bju" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 9bju is ON HOLD Authors: Murray, J.M., Wu, H., Fuhrmann, J., Fairbrother, W.J., DiPasquale, A. Description: Crystal structure of the complex betwee...