Adaptin - Revision history

Michal Harel at 08:28, 28 April 2020

Michal Harel — Tue, 28 Apr 2020 08:28:27 GMT

←Older revision		Revision as of 08:28, 28 April 2020
Line 1:		Line 1:
	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
-	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The '''AP-2 complex''' is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. ~~AP complexes connect~~ proteins and ~~lipids~~ to clathrin ~~budding sites~~. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>	+	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits.<br />
		+	The '''AP-2 complex''' is a heterotetramer composed a core domain containing 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ, 2 appendage domains or '''EAR'''. The core domain binds to the membrane and to cargo proteins which should be internalized and the EAR domains bind to clathrin and accessory proteins. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>
	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
	*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>		*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
		+
		+	The '''AP-1 complex''' heterotetramer μ subunit packages insulin receptor substrates into clathrin-coated vescicles. This is needed for insulin/insulin-like growth factor bioactivities including mitogenesis<ref>PMID:23478262</ref>.
		+
		+	The '''AP-3 complex''' heterotetramer is involved in the biogenesis of lysosome-related organelles<ref>PMID:15469849</ref>. It contains subunits β3, μ3, δ and σ3<ref>PMID:9151686</ref>.
		+
		+	The '''AP-4 complex''' heterotetramer is involved in the targeting proteins from the trans-Golgi network (TGN) to yhr endosomal-lysosomal system. It contains subunits β-type, μ-type, ε and σ-type<ref>PMID:11409905</ref>.

	==3D structures of adaptin==		==3D structures of adaptin==

Michal Harel at 15:13, 25 April 2020

Michal Harel — Sat, 25 Apr 2020 15:13:52 GMT

←Older revision		Revision as of 15:13, 25 April 2020
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	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
-	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>	+	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The '''AP-2 complex''' is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>
	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
	*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>		*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>

Michal Harel at 08:58, 28 February 2019

Michal Harel — Thu, 28 Feb 2019 08:58:26 GMT

←Older revision		Revision as of 08:58, 28 February 2019
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	</StructureSection>		</StructureSection>

-	===3D structures of adaptin===

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*AP-α-2
-
-	**[[1b9k]], [[1qts]] – mAP appendage domain – mouse<br />
-	**[[1qtp]] – mAP appendage domain (mutant)<br />
-	**[[1ky6]], [[1kyd]] – mAP appendage domain + epsin peptide<br />
-	**[[1ky7]] – mAP appendage domain + amphiphysin peptide<br />
-	**[[1kyf]], [[1kyu]] – mAP appendage domain + eps15 peptide<br />
-	**[[1w80]], [[2vj0]] – mAP appendage domain + synaptojanin peptide<br />
-	**[[3hs8]] – mAP appendage domain + intersectin peptide<br />
-
-	*AP-β
-
-	**[[1e42]] – hAP-1 appendage domain - human<br />
-	**[[2g30]] – hAP-1 appendage domain + ARH peptide<br />
-	**[[3h1z]] – hAP-1 appendage domain + PTDINSPKI-γ peptide<br />
-	**[[3hs9]] – hAP-1 appendage domain + intersectin peptide<br />
-	**[[2iv9]] – hAP-2 appendage domain + eps15 peptide<br />
-	**[[2iv8]] – hAP-2 appendage domain + B-arrestin peptide<br />
-	**[[1mj7]] – hAP-4 appendage domain <br />
-
-	*AP-γ
-
-	**[[1iu1]] – hAP-1 ear domain<br />
-	**[[1gyu]], [[2a7b]] – mAP-1 appendage domain <br />
-	**[[1gyv]], [[1gyw]], [[3zy7]] – mAP-1 appendage domain (mutant)<br />
-	**[[2e9g]], [[4bcx]] – hAP-2 ear domain<br />
-	**[[2ymt]] – hAP-2 ear domain + peptide<br />
-	**[[3zhf]] – hAP-2 ear domain + large envelope protein peptide<br />
-
-	*AP-δ-1
-
-	**[[4afi]] – hAP-1/vesicle-associated membrane protein 7<br />
-
-	*AP-μ
-
-	**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
-	**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
-	**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
-	**[[1bw8]], [[1i31]] – rAP-2 C-terminal + EGFR peptide<br />
-	**[[1bxx]] – rAP-2 C-terminal + TGN38 peptide<br />
-	**[[1hes]] – rAP-2 C-terminal + selectin peptide<br />
-	**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
-	**[[2pr9]] – rAP-2 C-terminal + GABA receptor peptide<br />
-	**[[5wrm]], [[5wrl]], [[5wrk]] – rAP-2 C-terminal + insulin receptor substrate peptide <br />
-	**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />
-	**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />
-	**[[6bnt]] – hAP-2 C-terminal + insulin receptor substrate peptide <br />
-
-	*AP-α2 + AP-σ
-
-	**[[4nee]] – rAP-2 + HIV-1 NEF <br />
-
-	*AP-α2 + AP-β + AP-σ
-
-	**[[4uqi]] – rAP-2 + VPU <br />
-
-	*AP-α + AP-β + AP-μ + AP-σ
-
-	**[[2vgl]] – rAPα-2 + APβ-1 + APμ-1 + APσ-1 <br />
-	**[[4uqi]] – rAPα-2 + APβ-2 + APμ-2 + APσ-1 <br />
-	**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
-	**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
-
-	*AP-β-1 + AP-γ-1 + AP-μ-1 + AP-σ-3
-
-	**[[6dff]], [[6d84]], [[6d83]], [[6cri]], [[6cm9]] – hAPβ-1 + APμ-1 + APσ-3 + ARF1 + tetherin-NEF – Cryo EM <br />
-
-	*AP-γ + AP-β + AP-μ + AP-σ
-
-	**[[1w63]] – mAP-1 <br />
-	**[[4hmy]] – mAP-1 + ADP-ribosylation factor<br />
-	**[[4p6z]] – mAP-1 + VPU + bone marrow stromal antigen<br />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:57, 28 February 2019

Michal Harel — Thu, 28 Feb 2019 08:57:10 GMT

←Older revision		Revision as of 08:57, 28 February 2019
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	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
	*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>		*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
		+
		+	==3D structures of adaptin==
		+	[[Adaptin 3D structures]]
		+
	</StructureSection>		</StructureSection>

Line 47:		Line 51:
	**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />		**[[3h85]] – rAP-1 appendage domain + PTDINSPKIγ peptide<br />
	**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />		**[[4emz]], [[4en2]] – mAP-1 sorting motif recognition domain + nef + MHC-I<br />
-	**[[1bw8]], [[1i31]] – rAP-2 + EGFR peptide<br />
-	**[[1bxx]] – rAP-2 + TGN38 peptide<br />
-	**[[1hes]] – rAP-2 + selectin peptide<br />
-	**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
	**[[2bp5]] – rAP-2 + purinoceptor peptide<br />		**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
-	**[[2pr9]] – rAP-2 + GABA receptor peptide<br />	+	**[[1bw8]], [[1i31]] – rAP-2 C-terminal + EGFR peptide<br />
		+	**[[1bxx]] – rAP-2 C-terminal + TGN38 peptide<br />
		+	**[[1hes]] – rAP-2 C-terminal + selectin peptide<br />
		+	**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
		+	**[[2pr9]] – rAP-2 C-terminal + GABA receptor peptide<br />
		+	**[[5wrm]], [[5wrl]], [[5wrk]] – rAP-2 C-terminal + insulin receptor substrate peptide <br />
	**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />		**[[4ikn]] – rAP-3 + TGN38 sorting peptide <br />
	**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />		**[[3l81]], [[4mdr]] – hAP-4 + amyloid beta-A4 peptide <br />
		+	**[[6bnt]] – hAP-2 C-terminal + insulin receptor substrate peptide <br />

	*AP-α2 + AP-σ		*AP-α2 + AP-σ
Line 70:		Line 76:
	**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />		**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
	**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />		**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />
		+
		+	*AP-β-1 + AP-γ-1 + AP-μ-1 + AP-σ-3
		+
		+	**[[6dff]], [[6d84]], [[6d83]], [[6cri]], [[6cm9]] – hAPβ-1 + APμ-1 + APσ-3 + ARF1 + tetherin-NEF – Cryo EM <br />

	*AP-γ + AP-β + AP-μ + AP-σ		*AP-γ + AP-β + AP-μ + AP-σ

Alexander Berchansky at 14:27, 23 April 2018

Alexander Berchansky — Mon, 23 Apr 2018 14:27:41 GMT

←Older revision		Revision as of 14:27, 23 April 2018
Line 2:		Line 2:
	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>		'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>
	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
-	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>	+	*<scene name='55/559108/Cv/6'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
	</StructureSection>		</StructureSection>

Michal Harel at 10:41, 21 February 2017

Michal Harel — Tue, 21 Feb 2017 10:41:00 GMT

←Older revision		Revision as of 10:41, 21 February 2017
Line 1:		Line 1:
	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
-	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>	+	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 '''large AP''': AP-α or AP-γ and AP-β, a '''medium-size AP''': AP-μ and '''small AP''': AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>
	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>		*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>

Michal Harel at 16:05, 1 November 2016

Michal Harel — Tue, 01 Nov 2016 16:05:18 GMT

←Older revision		Revision as of 16:05, 1 November 2016
Line 50:		Line 50:
	**[[1bxx]] – rAP-2 + TGN38 peptide<br />		**[[1bxx]] – rAP-2 + TGN38 peptide<br />
	**[[1hes]] – rAP-2 + selectin peptide<br />		**[[1hes]] – rAP-2 + selectin peptide<br />
		+	**[[5c7z]], [[5fpi]] – rAP-2 C terminal + integrin peptide<br />
	**[[2bp5]] – rAP-2 + purinoceptor peptide<br />		**[[2bp5]] – rAP-2 + purinoceptor peptide<br />
	**[[2pr9]] – rAP-2 + GABA receptor peptide<br />		**[[2pr9]] – rAP-2 + GABA receptor peptide<br />
Line 66:		Line 67:

	**[[2vgl]] – rAPα-2 + APβ-1 + APμ-1 + APσ-1 <br />		**[[2vgl]] – rAPα-2 + APβ-1 + APμ-1 + APσ-1 <br />
		+	**[[4uqi]] – rAPα-2 + APβ-2 + APμ-2 + APσ-1 <br />
	**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />		**[[2jkr]], [[2jkt]] – mAPα-2 + APβ-1 + APμ-1 + APσ-1 + CD4 peptide<br />
	**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />		**[[2xa7]] – rAPα-2 + APβ + APμ + APσ + cargo peptide<br />

Alexander Berchansky at 09:05, 6 December 2015

Alexander Berchansky — Sun, 06 Dec 2015 09:05:49 GMT

←Older revision		Revision as of 09:05, 6 December 2015
Line 1:		Line 1:
	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
-	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref>PMID:12086608</ref>	+	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref name="Ad">PMID:12086608</ref>
	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.		*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
-	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref>PMID:12086608</ref>	+	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref name="Ad">PMID:12086608</ref>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:04, 6 December 2015

Alexander Berchansky — Sun, 06 Dec 2015 09:04:14 GMT

←Older revision		Revision as of 09:04, 6 December 2015
Line 1:		Line 1:
	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref>PMID:12086608</ref>		'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref>PMID:12086608</ref>
-	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene> ~~([[2vgl]])~~.	+	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene>.
-	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene>.	+	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene> ([[2vgl]]).<ref>PMID:12086608</ref>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:02, 6 December 2015

Alexander Berchansky — Sun, 06 Dec 2015 09:02:48 GMT

←Older revision		Revision as of 09:02, 6 December 2015
Line 1:		Line 1:
	<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>		<StructureSection load='2vgl' size='350' side='right' caption='Structure of Adaptin core: AP-α-2 (cyan), AP-β-1 (magenta), AP-μ-1 (green), AP-σ-1 (olive) complex with inositole hexakisphosphate (PDB entry [[2vgl]])' scene='55/559108/Cv/1'>
	'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref>PMID:12086608</ref>		'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a heterotetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals.<ref>PMID:12086608</ref>
-	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene> ([[2vgl]])	+	*<scene name='55/559108/Cv/3'>Adaptin core: AP-α-2, AP-β-1, AP-μ-1, AP-σ-1 complex with inositole hexakisphosphate</scene> ([[2vgl]]).
		+	*<scene name='55/559108/Cv/5'>Inositole hexakisphosphate binding site</scene>.
	</StructureSection>		</StructureSection>