Aminopeptidase - Revision history

Michal Harel at 08:01, 26 May 2024

Michal Harel — Sun, 26 May 2024 08:01:38 GMT

←Older revision		Revision as of 08:01, 26 May 2024
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	* '''Deblocking aminopeptidase''' (DAP) is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />		* '''Deblocking aminopeptidase''' (DAP) is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
	* '''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.		* '''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.
		+	* '''M1 family AP''' are Zn+2 containing amino peptidases<ref>PMID:25530263</ref><br />
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.

Michal Harel at 07:55, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:55:48 GMT

←Older revision		Revision as of 07:55, 26 May 2024
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	== Function ==		== Function ==

-	[[Aminopeptidase\|Aminopeptidases]] (AP) ([[EC]] 3) are metal - mostly Zn-dependent enzymes involved in the digestion of proteins. '''Cytosol AP''' (Cyt-AP~~), '''deblocking AP''' (DAP~~) and '''AP N''' (APN) remove N-terminal amino acids. The AP are classified by the amino acid which they hydrolyze. Other types of AP are:<br />	+	[[Aminopeptidase\|Aminopeptidases]] (AP) ([[EC]] 3) are metal - mostly Zn-dependent enzymes involved in the digestion of proteins. '''Cytosol AP''' (Cyt-AP) and '''AP N''' (APN) remove N-terminal amino acids. The AP are classified by the amino acid which they hydrolyze. Other types of AP are:<br />
	* '''Cold-activated AP''' (Col-AP)<br />		* '''Cold-activated AP''' (Col-AP)<br />
	* '''Heat stable AP''' from ''Thermus thermophilus'' (AmpT)<br />		* '''Heat stable AP''' from ''Thermus thermophilus'' (AmpT)<br />
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	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br />		* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br />
	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />		* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />
-	* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />	+	* '''Deblocking aminopeptidase''' (DAP) is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
	* '''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.		* '''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.

Michal Harel at 07:54, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:54:42 GMT

←Older revision		Revision as of 07:54, 26 May 2024
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	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />		* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />
	* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />		* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
-	*'''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.	+	* '''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.

Michal Harel at 07:54, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:54:17 GMT

←Older revision		Revision as of 07:54, 26 May 2024
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	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />		* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />
	* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />		* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
-	~~Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.~~ Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>	+	*'''Beta-peptidyl AP''' (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref><br />.
		+	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide.

	== Aminopeptidase from ''Aeromonas proteolytica''<ref>DOI 10.1007/s00775-012-0873-4</ref> ==		== Aminopeptidase from ''Aeromonas proteolytica''<ref>DOI 10.1007/s00775-012-0873-4</ref> ==

Michal Harel at 07:52, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:52:44 GMT

←Older revision		Revision as of 07:52, 26 May 2024
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	* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />		* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />
	* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />		* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
-	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>	+	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br />
-	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br '>	+	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />
		+	* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>

Michal Harel at 07:44, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:44:05 GMT

←Older revision		Revision as of 07:44, 26 May 2024
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	* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />		* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />
	* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />		* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
-	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br />	+	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>
-	* '''Aminopeptidase C''' is ~~an exoprotease~~ aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />	+	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br '>
-	* '~~''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br /~~>	+
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>

Michal Harel at 07:43, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:43:52 GMT

←Older revision		Revision as of 07:43, 26 May 2024
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	* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />		* '''AP from ''Staphylococcus aureus''''' (AmpS)<br />
	* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />		* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
-	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>	+	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br />
-	* '''Aminopeptidase C''' is ~~a Phe~~ aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br '>	+	* '''Aminopeptidase C''' is an exoprotease aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br />
		+	* '''Deblocking aminopeptidase''' is an exoprotease aminopeptidase which can release N-terminal amino acids from blocked peptides<ref>PMID:21670507</ref>.<br />
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>

Michal Harel at 07:43, 26 May 2024

Michal Harel — Sun, 26 May 2024 07:43:01 GMT

←Older revision		Revision as of 07:43, 26 May 2024
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	* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />		* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>		* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>
-	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''~~Aspergillu~~ niger''<ref>PMID:12571053</ref>.<br '>	+	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillus niger''<ref>PMID:12571053</ref>.<br '>
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>

Michal Harel at 09:43, 23 May 2024

Michal Harel — Thu, 23 May 2024 09:43:09 GMT

←Older revision		Revision as of 09:43, 23 May 2024
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	* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />		* '''SGAP''' from ''Stereomyces griseus''. See details in [[Streptomyces griseus Aminopeptidase (SGAP)]].<br />
	* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>		* '''Alanine aminopeptidase''' is called '''aminopeptidase N'''. See details in [[Aminopeptidase N]].<br '>
		+	* '''Aminopeptidase C''' is a Phe aminopeptidase from ''Aspergillu niger''<ref>PMID:12571053</ref>.<br '>
	Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>		Aminopeptidases catalyze a release of an N-terminal amino acid from a peptide, amide, or arylamide. Beta-peptidyl AP (BapA) cleaves N-terminal β-homoamino acid from peptides of length 2 to 6.<ref>PMID:8440407</ref>

Michal Harel at 11:01, 13 March 2019

Michal Harel — Wed, 13 Mar 2019 11:01:43 GMT

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