Aminotransferase - Revision history

Michal Harel at 08:50, 26 May 2024

Michal Harel — Sun, 26 May 2024 08:50:35 GMT

←Older revision		Revision as of 08:50, 26 May 2024
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	'''PseC aminotransferase''' is an aminotransferase in the pathway of biosynthesis of pseudaminic acid<ref>PMID:16421095</ref>.		'''PseC aminotransferase''' is an aminotransferase in the pathway of biosynthesis of pseudaminic acid<ref>PMID:16421095</ref>.
		+
		+	'''WbpE aminotransferase''' is a PLP-dependent aminotransferase in the pathway of biosynthesis of ''Pseudomonas aerugingsa'' central carbohydrate<ref>PMID:20604544</ref>.

	See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].		See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].

Michal Harel at 08:42, 26 May 2024

Michal Harel — Sun, 26 May 2024 08:42:43 GMT

←Older revision		Revision as of 08:42, 26 May 2024
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	'''ArnB aminotransferase''' is a PLP-dependent aminotransferase in the pathway of biosynthesis of arabinose-4N lipid A<ref>PMID:24460375</ref>.		'''ArnB aminotransferase''' is a PLP-dependent aminotransferase in the pathway of biosynthesis of arabinose-4N lipid A<ref>PMID:24460375</ref>.
		+
		+	'''PseC aminotransferase''' is an aminotransferase in the pathway of biosynthesis of pseudaminic acid<ref>PMID:16421095</ref>.

	See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].		See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].

Michal Harel at 08:35, 26 May 2024

Michal Harel — Sun, 26 May 2024 08:35:25 GMT

←Older revision		Revision as of 08:35, 26 May 2024
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	'''Lysine aminotransferase''' (LYSAT) catalyzes the intercorversion of lysine and oxoglutarate to aminoadipate semialdeyde and glutamate.		'''Lysine aminotransferase''' (LYSAT) catalyzes the intercorversion of lysine and oxoglutarate to aminoadipate semialdeyde and glutamate.
		+
		+	'''ArnB aminotransferase''' is a PLP-dependent aminotransferase in the pathway of biosynthesis of arabinose-4N lipid A<ref>PMID:24460375</ref>.

	See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].		See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].

Alexander Berchansky at 11:05, 25 July 2021

Alexander Berchansky — Sun, 25 Jul 2021 11:05:51 GMT

←Older revision		Revision as of 11:05, 25 July 2021
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	'''Lysine aminotransferase''' (LYSAT) catalyzes the intercorversion of lysine and oxoglutarate to aminoadipate semialdeyde and glutamate.		'''Lysine aminotransferase''' (LYSAT) catalyzes the intercorversion of lysine and oxoglutarate to aminoadipate semialdeyde and glutamate.
		+
		+	See also [[Journal:Acta Cryst F:S1744309112050270\|Crystal structure of ADL1, a plant-specific homologue of the universal diaminopimelate amino transferase enzyme of lysine biosynthesis]].

	== Relevance ==		== Relevance ==

Michal Harel at 09:01, 14 March 2019

Michal Harel — Thu, 14 Mar 2019 09:01:10 GMT

(Difference between revisions)

Michal Harel at 08:56, 14 March 2019

Michal Harel — Thu, 14 Mar 2019 08:56:58 GMT

←Older revision		Revision as of 08:56, 14 March 2019
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	The <scene name='72/721044/Cv/3'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>		The <scene name='72/721044/Cv/3'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>

		+	==3D structures of aminotransferase==
		+	[[Aminotransferase 3D structures]]

	</StructureSection>		</StructureSection>
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	**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />		**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />
	**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />		**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />
-	**[[4r8d]], [[5c6u]] – MtHPA + PLP <br />	+	**[[4r8d]], [[5c6u]], [[5yhv]] – MtHPA + PLP <br />

	*Ornithine aminotransferase		*Ornithine aminotransferase
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	**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />		**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />
	**[[4cmf]] – NhBCAT + inhibitor <br />		**[[4cmf]] – NhBCAT + inhibitor <br />
-	**[[~~5e25~~]] – ~~BCAT~~ + PLP ~~+ ketoglutarate~~ – ''Geoglobus acetivorans'' <br />	+	**[[5cm0]] – GaBCAT + PLP – ''Geoglobus acetivorans'' <br />
		+	**[[5e25]] – GaBCAT + PLP + ketoglutarate <br />
	**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />		**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
	**[[5u3f]] – MtBCAT + cycloserine <br />		**[[5u3f]] – MtBCAT + cycloserine <br />
		+	**[[6nst]] - BCAT – ''Pseudomonas aeruginosa''<br />
		+	**[[6gkr]] – TtBCAT + PLP – ''Thermobaculum terrenum'' <br />
		+	**[[6q8e]] – TtBCAT + PLP derivative <br />
		+	**[[6h65]] – TtBCAT + PLP – ''Haliangium ochraceum'' <br />
		+	**[[4whx]] – BCAT + PLP – ''Burkholderia pseudomallei'' <br />

	*Aromatic amino acid aminotransferase		*Aromatic amino acid aminotransferase
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	**[[4rkc]] – PsAROAT + PLP derivative - ''Psychrobacter''<br />		**[[4rkc]] – PsAROAT + PLP derivative - ''Psychrobacter''<br />
	**[[4rkd]] – PsAROAT + PLP derivative + PLP<br />		**[[4rkd]] – PsAROAT + PLP derivative + PLP<br />
		+	**[[6hnb]] – CaAROAT – ''Candida albicans'' <br />
		+	**[[6hnu]] – CaAROAT + PLP + Phe<br />

	*Tyrosine aminotransferase		*Tyrosine aminotransferase
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	**[[3ihj]] – hALAAT 2 + PLP <br />		**[[3ihj]] – hALAAT 2 + PLP <br />
	**[[3tcm]] – ALAAT 2 (mutant) + PLP derivative - barley<br />		**[[3tcm]] – ALAAT 2 (mutant) + PLP derivative - barley<br />
		+
		+	*Cysteine aminotransferase
		+
		+	**[[4w91]] – CYSAT + PLP – ''Brucella suis''<br />

	*Glutamine aminotransferase		*Glutamine aminotransferase
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	*WbpE aminotransferase		*WbpE aminotransferase

-	**[[3nu7]], [[3nu8]], [[3nub]], [[3nyu]] - PaWbpE + PLP derivative ~~– ''Pseudomonas aeruginosa''~~<br />	+	**[[3nu7]], [[3nu8]], [[3nub]], [[3nyu]] - PaWbpE + PLP derivative <br />
	**[[3nys]] - PaWbpE (mutant) + PLP <br />		**[[3nys]] - PaWbpE (mutant) + PLP <br />
	**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />		**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
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	*C-6’ aminotransferase		*C-6’ aminotransferase

-	**[[6cbo]] - AT – ''Micromonospora echinospora'' <br />	+	**[[6cbo]] - MeAT – ''Micromonospora echinospora'' <br />
		+	**[[5z83]] – MeAT + PLP <br />
		+	**[[5z8a]] – MeAT + PLP + JI-20A <br />
		+	**[[5z8k]] – MeAT + PLP + neomycin <br />

	*Kynurenine aminotransferase		*Kynurenine aminotransferase

-	**[[~~5veh]] – AaKAT + PLP derivative <br />~~	+	**[[4wlh]], [[4wlj]], [[4wp0]] – hKAT 1 + PLP derivative <br />
-	**[[5vep]], [[~~5veq~~]], [[~~5ver~~]] – ~~mKAT 3~~ + PLP derivative <br />	+	**[[5efs]], [[6d0a]] – hKAT 2 <br />
-	**[[~~4wlh~~]], [[~~4wlj]] – hKAT 1 + PLP derivative <br />~~	+
-	**[[5efs]] – hKAT 2 <br />	+
	**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />		**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />
		+	**[[5vep]], [[5veq]], [[5ver]] – mKAT 3 + PLP derivative <br />
		+	**[[5veh]] – AaKAT + PLP derivative <br />
		+
		+	*Diaminopelargonic acid aminotransferase
		+
		+	**[[6erk]] – DPAAT + PLP – ''Psychrobacter cryohalolentis'' <br />
		+
		+	*D-phenylglycine aminotransferase
		+
		+	**[[6dvs]] – DPGAT – ''Pseudomonas stutzeri'' <br />
		+
		+	*Aminotransferase class II
		+
		+	**[[5z0q]] – AT2 + PLP – ''Erwinia tasmaniensis'' <br />

	*Aminotransferase class III		*Aminotransferase class III

Alexander Berchansky at 12:26, 2 May 2018

Alexander Berchansky — Wed, 02 May 2018 12:26:52 GMT

←Older revision		Revision as of 12:26, 2 May 2018
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	== Structural highlights ==		== Structural highlights ==

-	The <scene name='72/721044/Cv/2'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>	+	The <scene name='72/721044/Cv/3'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>

Michal Harel at 11:07, 13 March 2018

Michal Harel — Tue, 13 Mar 2018 11:07:00 GMT

←Older revision		Revision as of 11:07, 13 March 2018
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	**[[2eh6]] – ACOAT + PLP – ''Aquifex aeolicus'' <br />		**[[2eh6]] – ACOAT + PLP – ''Aquifex aeolicus'' <br />
	**[[3nx3]] – CjACOAT – ''Campylobacter jejuni'' <br />		**[[3nx3]] – CjACOAT – ''Campylobacter jejuni'' <br />
		+	**[[5viu]] – ACOAT – ''Elizabethkingia anophelis'' <br />
		+	**[[4jev]] – StACOAT + PLP derivative – ''Salmonella typhimurium'' <br />
		+	**[[4jey]] – StACOAT (mutant) + PLP <br />
		+	**[[4jf0]], [[4f01]] – StACOAT (mutant) + PLP derivative<br />
		+	**[[4jew]], [[4jex]], [[4jez]] – StACOAT (mutant) + canaline <br />

	*Succinylornithine aminotransferase		*Succinylornithine aminotransferase
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	*Alanine glyoxylate aminotransferase		*Alanine glyoxylate aminotransferase

-	**[[1h0c]], [[2yob]], [[5f9s]] – hAGA + PLP <br />	+	**[[1h0c]], [[2yob]], [[5f9s]], [[5og0]] – hAGA + PLP <br />
-	**[[4cbr]], [[4cbs]] – hAGA (mutant) + PLP <br />	+	**[[4cbr]], [[4cbs]], [[5ofy]], [[5luc]] – hAGA (mutant) + PLP <br />
	**[[1j04]], [[5hhy]] – hAGA + PLP derivative <br />		**[[1j04]], [[5hhy]] – hAGA + PLP derivative <br />
	**[[4i8a]] – hAGA (mutant) + PLP derivative <br />		**[[4i8a]] – hAGA (mutant) + PLP derivative <br />
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	**[[1ekf]], [[1ekp]], [[1ekv]] – hBCAT + PLP <br />		**[[1ekf]], [[1ekp]], [[1ekv]] – hBCAT + PLP <br />
		+	**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]], [[5mpr]] – hBCAT (mutant) + PLP <br />
	**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />		**[[1kt8]], [[1kta]] – hBCAT + PLP derivative <br />
	**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />		**[[2alh]], [[5bwr]], [[5bwt]], [[5bwu]], [[5bwv]], [[5bwx]], [[5bww]], [[5cr5]] – hBCAT + PLP + inhibitor <br />
	**[[5i60]], [[5i5y]], [[5i5x]], [[5i5w]], [[5i5v]], [[5i5u]], [[5i5t]], [[5i5s]], [[5hne]] – hBCAT + PLP + biaryl amide<br />		**[[5i60]], [[5i5y]], [[5i5x]], [[5i5w]], [[5i5v]], [[5i5u]], [[5i5t]], [[5i5s]], [[5hne]] – hBCAT + PLP + biaryl amide<br />
-	**[[2hdk]], [[2hgw]], [[2hgx]], [[2hhf]] – hBCAT (mutant) + PLP <br />
	**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />		**[[2hg8]] – hBCAT (mutant) + PLP + methylleucine <br />
	**[[4chi]] – AfBCAT + PLP – ''Aspergillus fumigatus'' <br />		**[[4chi]] – AfBCAT + PLP – ''Aspergillus fumigatus'' <br />
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	**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />		**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />
	**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />		**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
		+	**[[5u3f]] – MtBCAT + cycloserine <br />

	*Aromatic amino acid aminotransferase		*Aromatic amino acid aminotransferase
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	**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />		**[[3r4t]] – GABA + PLP derivative – ''Mycobacterium marinum''<br />
	**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />		**[[4ffc]] – GABA + PLP derivative – ''Mycobacterium abscessus''<br />
-	**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]] – GABA + inactivator - pig <br />	+	**[[4zsy]], [[4zsw]], [[4y0i]], [[4y0h]], [[4y0d]], [[6b6g]] – GABA + inactivator - pig <br />

	*ArnB aminotransferase		*ArnB aminotransferase

-	**[[1mdo]] - StArnB + PLP derivative ~~– ''Salmonella typhimurium''~~<br />	+	**[[1mdo]] - StArnB + PLP derivative <br />
	**[[1mdx]] – StArnB + PLP + oxoglutarate<br />		**[[1mdx]] – StArnB + PLP + oxoglutarate<br />
	**[[1mdz]] – StArnB + PLP + PLP derivative<br />		**[[1mdz]] – StArnB + PLP + PLP derivative<br />
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	*Alpha-aminoadipate aminotransferase		*Alpha-aminoadipate aminotransferase

-	**[[2egy]], [[5eun]] - ~~TtLysN~~ + PLP <br />	+	**[[2egy]], [[5eun]] - TtAADAT + PLP <br />
-	**[[3cbf]], [[2zyj]] - ~~TtLysN~~ + PLP derivative<br />	+	**[[3cbf]], [[2zyj]] - TtAADAT + PLP derivative<br />
-	**[[2zp7]], [[2z1y]] - ~~TtLysN~~ + PLP + leucine<br />	+	**[[2zp7]], [[2z1y]] - TtAADAT + PLP + leucine<br />
-	**[[~~5tf5~~]] - ~~hLysN~~ + PLP derivative + ~~inhibitor<br />~~	+	**[[4je5]] - AADAT + PLP derivative + PLP - yeast<br />
-	**[[5efs]] - ~~hLysN II~~ <br />	+

	*Broad specificity aminotransferase		*Broad specificity aminotransferase
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	*Adenosylmethionine-8-amino-7-oxononanoate aminotransferase		*Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

-	**[[4w1x]], [[4w1w]], [[4w1v]], [[4xjl]], [[4xjm]], [[4xjo]], [[4xjp]] - MtDAPA + PLP + inhibitor<br />	+	**[[4w1x]], [[4w1w]], [[4w1v]], [[4xjl]], [[4xjm]], [[4xjo]], [[4xjp]], [[4wya]], [[4wyc]], [[4wyd]], [[4wye]], [[4wyf]], [[4wyg]], [[4xew]] - MtDAPA + PLP + inhibitor<br />
	**[[4mqr]], [[4mqq]], [[4mqp]] - MtDAPA + inhibitor<br />		**[[4mqr]], [[4mqq]], [[4mqp]] - MtDAPA + inhibitor<br />
	**[[5uc7]] - DAPA + PLP derivative – ''Citrobacter rodentium''<br />		**[[5uc7]] - DAPA + PLP derivative – ''Citrobacter rodentium''<br />
		+	**[[5te2]] - MbDAPA + inhibitor – ''Mycobacterium bovis''<br />
		+	**[[5kgs]], [[5kgt]] - MbDAPA + PLP + inhibitor<br />

	*Putrescine aminotransferase		*Putrescine aminotransferase
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	**[[4uho]], [[4uhn]], [[4uhm]] - PaOAAT + PLP <br />		**[[4uho]], [[4uhn]], [[4uhm]] - PaOAAT + PLP <br />
		+
		+	*C-6’ aminotransferase
		+
		+	**[[6cbo]] - AT – ''Micromonospora echinospora'' <br />
		+
		+	*Kynurenine aminotransferase
		+
		+	**[[5veh]] – AaKAT + PLP derivative <br />
		+	**[[5vep]], [[5veq]], [[5ver]] – mKAT 3 + PLP derivative <br />
		+	**[[4wlh]], [[4wlj]] – hKAT 1 + PLP derivative <br />
		+	**[[5efs]] – hKAT 2 <br />
		+	**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />
		+
		+	*Aminotransferase class III
		+
		+	**[[5ghg]], [[5ghf]] – AT3 + PLP derivative – ''Orchrobactrum anthropi''<br />
		+	**[[5m46]] – RfAT3 + PLP – ''Rhizobium freirei''<br />
		+	**[[5m49]] – RfAT3 + PLP + azepan derivative<br />
		+	**[[5m4b]], [[5m4d]] – RfAT3 (mutant) + azepan derivative<br />
		+	**[[5d95]] – AT3 + PLP derivative – ''Sphaerobacter thermophilus''<br />
		+
		+	*Aminotransferase class IV
		+
		+	**[[4tvi]] – AT4 + PLP derivative – ''Brucella abortus''<br />
		+

	}}		}}

Joel L. Sussman at 19:44, 18 October 2017

Joel L. Sussman — Wed, 18 Oct 2017 19:44:15 GMT

←Older revision		Revision as of 19:44, 18 October 2017
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-	<StructureSection load='~~1gew~~' size='350' side='right' caption='E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code [[1gew]])' scene='72/721044/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code [[1gew]])' scene='72/721044/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

Michal Harel at 18:50, 18 October 2017

Michal Harel — Wed, 18 Oct 2017 18:50:59 GMT

←Older revision		Revision as of 18:50, 18 October 2017
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]