Ankyrin - Revision history

Michal Harel at 10:12, 21 March 2021

Michal Harel — Sun, 21 Mar 2021 10:12:29 GMT

←Older revision		Revision as of 10:12, 21 March 2021
Line 16:		Line 16:
	*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br />		*'''ANK3''' or '''ankyrin-G''' is found in the nervous system and associates with Na channels.<br />

-	'''Gankyrin''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats.	+	'''Gankyrin''' or '''26S proteasome non-ATPase regulatory subunit 10''' (GANK) is an oncoprotein which is a component of the 19S cap of the proteasome. GANK contains ankyrin repeats.

	== Disease ==		== Disease ==

Michal Harel at 10:41, 6 March 2019

Michal Harel — Wed, 06 Mar 2019 10:41:48 GMT

←Older revision		Revision as of 10:41, 6 March 2019
Line 34:		Line 34:

	</StructureSection>		</StructureSection>
-	== 3D Structures of ankyrin ==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Ankyrin
-
-	**[[3so8]] – hANK-1 residues 149-310 - human<br />
-	**[[1n11]] – hANK-1 D34 region 402-827<br />
-	**[[2yqf]], [[2yvi]] – hANK-1 death domain 1394-1497 – NMR<br />
-	**[[3f59]] – hANK-1 spectrin-binding domain 911-1068<br />
-	**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains 911-1233<br />
-	**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains 966-1535<br />
-	**[[4rlv]] - hANK-1 + hANK-2<br />
-	**[[5y4d]] - hANK-1/hANK-2<br />
-	**[[5y4e]] - hANK-2 residues 264-483, 857-896<br />
-	**[[5y4f]] - hANK-2 residues 430-873<br />
-	**[[4o6x]] - hANK-3 death domain<br />
-	**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
-	**[[2aja]] – LpANK – ''Legionella pneumophila''<br />
-	**[[5k34]] – LpANK-2 <br />
-	**[[3hra]] – ANK – ''Enterococus faecalis''<br />
-	**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />
-
-	*Ankyrin complexes
-
-	**[[3kbt]], [[3kbu]] - hANK-1 spectrin-binding domain + spectrin β chain<br />
-	**[[4qqi]] - hANK-2 + RFX7<br />
-	**[[4lg6]] - hANK-2 + CCDC-8<br />
-	**[[1svx]] – dANK + maltose-binding protein<br />
-	**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
-	**[[5k35]] – LpANK-2 + SKP1<br />
-	**[[4zhb]] – LpANK-2 N-terminal + peptide<br />
-	**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
-
-	*Gankyrin
-
-	**[[1uoh]], [[1qym]] – hGANK<br />
-	**[[1tr4]] – hGANK – NMR<br />
-	**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:33, 6 March 2019

Michal Harel — Wed, 06 Mar 2019 10:33:48 GMT

←Older revision		Revision as of 10:33, 6 March 2019
Line 29:		Line 29:

	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>		Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>
		+
		+	== 3D Structures of ankyrin ==
		+	[[Ankyrin 3D structures]]

	</StructureSection>		</StructureSection>
-	== 3D Structures of ~~Ankyrin~~ ==	+	== 3D Structures of ankyrin ==

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Line 38:		Line 41:
	*Ankyrin		*Ankyrin

-	**[[1n11]] – hANK-1 D34 region ~~– human~~<br />	+	**[[3so8]] – hANK-1 residues 149-310 - human<br />
-	**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />	+	**[[1n11]] – hANK-1 D34 region 402-827<br />
-	**[[3f59]] – hANK-1 spectrin-binding domain<br />	+	**[[2yqf]], [[2yvi]] – hANK-1 death domain 1394-1497 – NMR<br />
-	**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />	+	**[[3f59]] – hANK-1 spectrin-binding domain 911-1068<br />
-	**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains~~<br />~~	+	**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains 911-1233<br />
-	**[[4o6x]] - ~~hANK-3 death domain~~<br />	+	**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains 966-1535<br />
	**[[4rlv]] - hANK-1 + hANK-2<br />		**[[4rlv]] - hANK-1 + hANK-2<br />
	**[[5y4d]] - hANK-1/hANK-2<br />		**[[5y4d]] - hANK-1/hANK-2<br />
-	**[[~~5yre~~]] - hANK-2 residues 264-483, 857-896<br />	+	**[[5y4e]] - hANK-2 residues 264-483, 857-896<br />
-	**[[~~5yrf~~]] - hANK-2 residues 430-873<br />	+	**[[5y4f]] - hANK-2 residues 430-873<br />
-	**[[~~3so8~~]] – hANK-~~A residues 149-310~~<br />	+	**[[4o6x]] - hANK-3 death domain<br />
	**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />		**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
	**[[2aja]] – LpANK – ''Legionella pneumophila''<br />		**[[2aja]] – LpANK – ''Legionella pneumophila''<br />
-	**[[5k34]] – LpANK B <br />	+	**[[5k34]] – LpANK-2 <br />
	**[[3hra]] – ANK – ''Enterococus faecalis''<br />		**[[3hra]] – ANK – ''Enterococus faecalis''<br />
	**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />		**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />
Line 57:		Line 60:
	*Ankyrin complexes		*Ankyrin complexes

-	**[[3kbt]], [[3kbu]] - hANK-1 ~~residues 911~~-~~1068~~ + spectrin β chain<br />	+	**[[3kbt]], [[3kbu]] - hANK-1 spectrin-binding domain + spectrin β chain<br />
	**[[4qqi]] - hANK-2 + RFX7<br />		**[[4qqi]] - hANK-2 + RFX7<br />
	**[[4lg6]] - hANK-2 + CCDC-8<br />		**[[4lg6]] - hANK-2 + CCDC-8<br />
	**[[1svx]] – dANK + maltose-binding protein<br />		**[[1svx]] – dANK + maltose-binding protein<br />
	**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />		**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
-	**[[5k35]] – LpANK B + SKP1<br />	+	**[[5k35]] – LpANK-2 + SKP1<br />
-	**[[4zhb]] – LpANK B N-terminal + peptide<br />	+	**[[4zhb]] – LpANK-2 N-terminal + peptide<br />
	**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />		**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />

Michal Harel at 11:14, 14 March 2018

Michal Harel — Wed, 14 Mar 2018 11:14:21 GMT

←Older revision		Revision as of 11:14, 14 March 2018
Line 44:		Line 44:
	**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />		**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
	**[[4o6x]] - hANK-3 death domain<br />		**[[4o6x]] - hANK-3 death domain<br />
-	**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
	**[[4rlv]] - hANK-1 + hANK-2<br />		**[[4rlv]] - hANK-1 + hANK-2<br />
-	**[[~~4qqi~~]] - hANK-2 ~~+ RFX7~~<br />	+	**[[5y4d]] - hANK-1/hANK-2<br />
-	**[[~~4lg6~~]] - hANK-2 ~~+ CCDC~~-8<br />	+	**[[5yre]] - hANK-2 residues 264-483, 857-896<br />
		+	**[[5yrf]] - hANK-2 residues 430-873<br />
	**[[3so8]] – hANK-A residues 149-310<br />		**[[3so8]] – hANK-A residues 149-310<br />
	**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />		**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
		+	**[[2aja]] – LpANK – ''Legionella pneumophila''<br />
		+	**[[5k34]] – LpANK B <br />
		+	**[[3hra]] – ANK – ''Enterococus faecalis''<br />
		+	**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />
		+
		+	*Ankyrin complexes
		+
		+	**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
		+	**[[4qqi]] - hANK-2 + RFX7<br />
		+	**[[4lg6]] - hANK-2 + CCDC-8<br />
	**[[1svx]] – dANK + maltose-binding protein<br />		**[[1svx]] – dANK + maltose-binding protein<br />
	**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />		**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
-	**[[2aja]] – LpANK – Legionella pneumophila<br />
-	**[[5k34]] – LpANK B <br />
	**[[5k35]] – LpANK B + SKP1<br />		**[[5k35]] – LpANK B + SKP1<br />
	**[[4zhb]] – LpANK B N-terminal + peptide<br />		**[[4zhb]] – LpANK B N-terminal + peptide<br />
-	**[[3hra]] – ANK – Enterococus faecalis<br />
	**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />		**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
-	**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />

	*Gankyrin		*Gankyrin

Michal Harel at 07:40, 6 March 2017

Michal Harel — Mon, 06 Mar 2017 07:40:31 GMT

←Older revision		Revision as of 07:40, 6 March 2017
Line 46:		Line 46:
	**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />		**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
	**[[4rlv]] - hANK-1 + hANK-2<br />		**[[4rlv]] - hANK-1 + hANK-2<br />
		+	**[[4qqi]] - hANK-2 + RFX7<br />
		+	**[[4lg6]] - hANK-2 + CCDC-8<br />
	**[[3so8]] – hANK-A residues 149-310<br />		**[[3so8]] – hANK-A residues 149-310<br />
	**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />		**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
	**[[1svx]] – dANK + maltose-binding protein<br />		**[[1svx]] – dANK + maltose-binding protein<br />
	**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />		**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
-	**[[2aja]] – ~~ANK~~ – Legionella pneumophila<br />	+	**[[2aja]] – LpANK – Legionella pneumophila<br />
		+	**[[5k34]] – LpANK B <br />
		+	**[[5k35]] – LpANK B + SKP1<br />
		+	**[[4zhb]] – LpANK B N-terminal + peptide<br />
	**[[3hra]] – ANK – Enterococus faecalis<br />		**[[3hra]] – ANK – Enterococus faecalis<br />
	**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />		**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
		+	**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />

	*Gankyrin		*Gankyrin

Michal Harel at 09:47, 2 December 2015

Michal Harel — Wed, 02 Dec 2015 09:47:53 GMT

←Older revision		Revision as of 09:47, 2 December 2015
Line 1:		Line 1:
-	<StructureSection load='1n11' size='~~450~~' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>	+	<StructureSection load='1n11' size='350' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>

Alexander Berchansky at 12:38, 11 November 2015

Alexander Berchansky — Wed, 11 Nov 2015 12:38:52 GMT

←Older revision		Revision as of 12:38, 11 November 2015
Line 28:		Line 28:
	== Structural highlights ==		== Structural highlights ==

-	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]].	+	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>

	</StructureSection>		</StructureSection>
Line 60:		Line 60:
	**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse		**[[2dvw]], [[2dwz]], [[3aji]] – GANK + 26S protease regulatory subunit 6B C terminal - mouse
	}}		}}
		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 12:36, 11 November 2015

Alexander Berchansky — Wed, 11 Nov 2015 12:36:28 GMT

←Older revision		Revision as of 12:36, 11 November 2015
Line 28:		Line 28:
	== Structural highlights ==		== Structural highlights ==

-	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>.	+	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]].

	</StructureSection>		</StructureSection>

Alexander Berchansky at 12:21, 11 November 2015

Alexander Berchansky — Wed, 11 Nov 2015 12:21:36 GMT

←Older revision		Revision as of 12:21, 11 November 2015
Line 28:		Line 28:
	== Structural highlights ==		== Structural highlights ==

-	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>.	+	Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>.
-		+
		+	</StructureSection>
	== 3D Structures of Ankyrin ==		== 3D Structures of Ankyrin ==

Alexander Berchansky at 12:21, 11 November 2015

Alexander Berchansky — Wed, 11 Nov 2015 12:21:01 GMT

←Older revision		Revision as of 12:21, 11 November 2015
Line 1:		Line 1:
-	<~~Structure~~ load='1n11' size='450' ~~frame~~='~~true~~' ~~align~~='~~right~~' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]' ~~scene='45/454440/Cv/1' /~~>	+	<StructureSection load='1n11' size='450' side='right' scene='45/454440/Cv/1' caption='Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions [[1n11]]'>
		+

	== Function ==		== Function ==