Ankyrin repeat domain-containing protein - Revision history

Michal Harel at 09:31, 26 May 2024

Michal Harel — Sun, 26 May 2024 09:31:26 GMT

←Older revision		Revision as of 09:31, 26 May 2024
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	== Disease ==		== Disease ==

-	Mutations in ARDCP 3 manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>.	+	Mutations in '''ARDCP 3''' manifest as Bartsocas-Papas syndrome, a genetic disorder characterized by severe craniofacial and limb abnormalities<ref>PMID:29706531</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 09:08, 11 September 2022

Michal Harel — Sun, 11 Sep 2022 09:08:37 GMT

←Older revision		Revision as of 09:08, 11 September 2022
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	== 3D structures of ankyrin repeat domain-containing protein ==		== 3D structures of ankyrin repeat domain-containing protein ==
-
	[[Ankyrin repeat domain-containing protein 3D structures]]		[[Ankyrin repeat domain-containing protein 3D structures]]

	</StructureSection>		</StructureSection>

-	== 3D structures of ankyrin repeat domain-containing protein ==
-
-	[[4nl9]] - hARDCP 3 SAM domain + hARDCP 14 SAM domain - human<br />
-	[[5ybj]] - hARDCP 15 residues 1080-1329<br />
-	[[5ybu]] - hARDCP 15 residues 1080-1329 + KIF21A peptide<br />
-	[[4hbd]] - hARDCP 25 residues 578-832<br />
-	[[6tmd]] - hARDCP 25 residues 583-832 (mutant)<br />
-	[[5ybv]] - hARDCP 25 residues 578-832 + KIF21A peptide<br />
-	[[4cym]] - hARDCP 27 residues 450-640 + RAB32<br />
-	[[4cz2]] - hARDCP 27 residues 450-640 + RAB32 + GPPCP<br />
-	[[4b93]] - hARDCP 27 residues 659-921 + VAMP7<br />
-	[[5wni]] - mARDCP 3 residues 1-342 - mouse<br />
-	[[5wnk]] - mARDCP 3 residues 1-342 (mutant)<br />
-	[[5wnj]], [[5wnm]] - mARDCP 3 residues 1-342 (mutant) + cancer drug<br />
-	[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />
-	[[6nxf]] - mARDCP 31 C-terminal + REC114<br />
-	[[6tlh]] - mARDCP 47 residues 524-773 <br />
-	[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />
-	[[6jd6]] - AtARDCP EMB56 + ARDCP<br />
-	[[7ubz]] – ARDCP residues 1-230 + lipase effector – ''Enterobacter cloacae''<br />
-
-	== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:06, 11 September 2022

Michal Harel — Sun, 11 Sep 2022 09:06:27 GMT

←Older revision		Revision as of 09:06, 11 September 2022
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	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.		The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.
		+
		+	== 3D structures of ankyrin repeat domain-containing protein ==
		+
		+	[[Ankyrin repeat domain-containing protein 3D structures]]

	</StructureSection>		</StructureSection>
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	[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />		[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />
	[[6jd6]] - AtARDCP EMB56 + ARDCP<br />		[[6jd6]] - AtARDCP EMB56 + ARDCP<br />
		+	[[7ubz]] – ARDCP residues 1-230 + lipase effector – ''Enterobacter cloacae''<br />
		+
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 10:31, 21 March 2021

Michal Harel — Sun, 21 Mar 2021 10:31:18 GMT

←Older revision		Revision as of 10:31, 21 March 2021
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	[[5ybu]] - hARDCP 15 residues 1080-1329 + KIF21A peptide<br />		[[5ybu]] - hARDCP 15 residues 1080-1329 + KIF21A peptide<br />
	[[4hbd]] - hARDCP 25 residues 578-832<br />		[[4hbd]] - hARDCP 25 residues 578-832<br />
		+	[[6tmd]] - hARDCP 25 residues 583-832 (mutant)<br />
	[[5ybv]] - hARDCP 25 residues 578-832 + KIF21A peptide<br />		[[5ybv]] - hARDCP 25 residues 578-832 + KIF21A peptide<br />
	[[4cym]] - hARDCP 27 residues 450-640 + RAB32<br />		[[4cym]] - hARDCP 27 residues 450-640 + RAB32<br />
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	[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />		[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />
	[[6nxf]] - mARDCP 31 C-terminal + REC114<br />		[[6nxf]] - mARDCP 31 C-terminal + REC114<br />
		+	[[6tlh]] - mARDCP 47 residues 524-773 <br />
	[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />		[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />
	[[6jd6]] - AtARDCP EMB56 + ARDCP<br />		[[6jd6]] - AtARDCP EMB56 + ARDCP<br />

Alexander Berchansky at 14:53, 27 October 2020

Alexander Berchansky — Tue, 27 Oct 2020 14:53:42 GMT

←Older revision		Revision as of 14:53, 27 October 2020
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/4'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.	+	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/6'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 14:50, 27 October 2020

Alexander Berchansky — Tue, 27 Oct 2020 14:50:36 GMT

←Older revision		Revision as of 14:50, 27 October 2020
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues KARR interact in an acidic pocket and residues QMELLYA interact in a hydrophobic pocket<ref name="Guo"/>.	+	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues <scene name='86/863150/Cv/3'>KARR interact in an acidic pocket</scene> and residues <scene name='86/863150/Cv/4'>QMELLYA interact in a hydrophobic pocket</scene><ref name="Guo"/>. <scene name='86/863150/Cv/5'>Whole kinesin peptide binding site</scene>.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:48, 27 October 2020

Alexander Berchansky — Tue, 27 Oct 2020 13:48:20 GMT

←Older revision		Revision as of 13:48, 27 October 2020
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-	<StructureSection load='5ybv' size='~~340~~' side='right' caption='Human ARDCP 25 (~~grey~~ and green) complex with kinesin peptide (pink and yellow), sulfate and glycerol (PDB code [[5ybv]]).' scene=''>	+	<StructureSection load='5ybv' size='400' side='right' caption='Human ARDCP 25 (cyan and green) complex with kinesin peptide (pink and yellow), sulfate and glycerol (PDB code [[5ybv]]).' scene='86/863150/Cv/1'>

	== Function ==		== Function ==

Joel L. Sussman at 11:38, 30 September 2020

Joel L. Sussman — Wed, 30 Sep 2020 11:38:39 GMT

←Older revision		Revision as of 11:38, 30 September 2020
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	== Function ==		== Function ==

-	'''Ankyrin repeat domain-containing protein''' (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain<ref>PMID:29183992</ref>.	+	'''Ankyrin repeat domain-containing protein''' (ARDCP) recruits kinesin to the cell cortex in order to control microtubule growth via its ankyrin domain<ref name="Guo">PMID:29183992</ref>.

	== Disease ==		== Disease ==
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	== Structural highlights ==		== Structural highlights ==

-	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues KARR interact in an acidic pocket and residues QMELLYA interact in a hydrophobic pocket<ref~~>PMID:29183992<~~/~~ref~~>.	+	The 3D structure of the complex between human ARDCP 25 C-terminal and a kinesin peptide shows 2 types of interactions. Kinesin residues KARR interact in an acidic pocket and residues QMELLYA interact in a hydrophobic pocket<ref name="Guo"/>.

	</StructureSection>		</StructureSection>

Michal Harel at 08:21, 30 September 2020

Michal Harel — Wed, 30 Sep 2020 08:21:26 GMT

←Older revision		Revision as of 08:21, 30 September 2020
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	== References ==		== References ==
	<references/>		<references/>
		+	[[Category:Topic Page]]

Michal Harel at 08:19, 30 September 2020

Michal Harel — Wed, 30 Sep 2020 08:19:44 GMT

←Older revision		Revision as of 08:19, 30 September 2020
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	[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />		[[5wnl]] - mARDCP 3 residues 1-342 (mutant) + staurosporine<br />
	[[6nxf]] - mARDCP 31 C-terminal + REC114<br />		[[6nxf]] - mARDCP 31 C-terminal + REC114<br />
-	[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - Arabidopis thaliana<br />	+	[[5eid]], [[4tum]] - AtARDCP 2 residues 211-342 - ''Arabidopis thaliana''<br />
	[[6jd6]] - AtARDCP EMB56 + ARDCP<br />		[[6jd6]] - AtARDCP EMB56 + ARDCP<br />
	== References ==		== References ==
	<references/>		<references/>