Art:Molecular Sculpture - Revision history

Eric Martz: /* Mara G. Haseltine */

Eric Martz — Mon, 19 Jul 2021 20:17:30 GMT

Mara G. Haseltine

←Older revision		Revision as of 20:17, 19 July 2021
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	:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.		:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.

-	In 2016, Hasentine installed [https://www.clotmag.com/oped/a-sculpture-for-the-age-of-corona-virus-dancing-on-the-line-between-art-and-scientific-discovery-by-mara-g-haseltine ''SARS Inhibited'' in a reflecting pool in Singapore's Biopolis]. Twelve meters wide, it represents a backbone trace of an X-ray structure of the ~~major~~ SARS protease.	+	In 2016, Hasentine installed [https://www.clotmag.com/oped/a-sculpture-for-the-age-of-corona-virus-dancing-on-the-line-between-art-and-scientific-discovery-by-mara-g-haseltine ''SARS Inhibited'' in a reflecting pool in Singapore's Biopolis]. Twelve meters wide, it represents a backbone trace of an X-ray structure of the main SARS protease [[1p9s]].

	==Eckhardt, Karim & Rehbein==		==Eckhardt, Karim & Rehbein==

Eric Martz: /* Mara G. Haseltine */

Eric Martz — Mon, 19 Jul 2021 20:08:01 GMT

Mara G. Haseltine

←Older revision		Revision as of 20:08, 19 July 2021
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	:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.		:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.

-	In 2016, Hasentine installed [https://www.clotmag.com/oped/a-sculpture-for-the-age-of-corona-virus-dancing-on-the-line-between-art-and-scientific-discovery-by-mara-g-haseltine ''SARS Inhibited'' in a reflecting pool in Singapore's Biopolis]]. Twelve meters wide, it represents a backbone trace of an X-ray structure of the major SARS protease.	+	In 2016, Hasentine installed [https://www.clotmag.com/oped/a-sculpture-for-the-age-of-corona-virus-dancing-on-the-line-between-art-and-scientific-discovery-by-mara-g-haseltine ''SARS Inhibited'' in a reflecting pool in Singapore's Biopolis]. Twelve meters wide, it represents a backbone trace of an X-ray structure of the major SARS protease.

	==Eckhardt, Karim & Rehbein==		==Eckhardt, Karim & Rehbein==

Eric Martz: /* Mara G. Haseltine */

Eric Martz — Mon, 19 Jul 2021 20:07:32 GMT

Mara G. Haseltine

←Older revision		Revision as of 20:07, 19 July 2021
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	:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.		:Homologous Hope is a delicate work of art that floats like a cloud above the atrium. Patients and their families entering the building look up and see hope on the horizon, hope inspired by the generosity of the Grays, by the creative environment of University, and by the efforts of the dedicated doctors and scientists.
		+
		+	In 2016, Hasentine installed [https://www.clotmag.com/oped/a-sculpture-for-the-age-of-corona-virus-dancing-on-the-line-between-art-and-scientific-discovery-by-mara-g-haseltine ''SARS Inhibited'' in a reflecting pool in Singapore's Biopolis]]. Twelve meters wide, it represents a backbone trace of an X-ray structure of the major SARS protease.

	==Eckhardt, Karim & Rehbein==		==Eckhardt, Karim & Rehbein==

Eric Martz: /* See Also */

Eric Martz — Thu, 18 Feb 2021 20:25:00 GMT

Eric Martz: /* Byron's Bender */

Eric Martz — Sat, 01 Feb 2020 21:19:11 GMT

Byron's Bender

←Older revision		Revision as of 21:19, 1 February 2020
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	An example illustrating the importance of models from Byron's Bender occurred at a scientific meeting in the mid 1970's. At this time, less than two dozen protein structures had been solved. David Davies brought a Bender model of an immunoglobulin Fab fragment, and Jane and David Richardson brought a Bender model of superoxide dismutase. While comparing these physical models at the meeting, they realized that both proteins use a similar fold, despite having only about 9% sequence identity. This incident<ref name="benderig">PMID: 1271464</ref> was the first recognition of the occurrence of what is now recognized as the immunoglobulin superfamily domain in proteins that are apparently unrelated by sequence.		An example illustrating the importance of models from Byron's Bender occurred at a scientific meeting in the mid 1970's. At this time, less than two dozen protein structures had been solved. David Davies brought a Bender model of an immunoglobulin Fab fragment, and Jane and David Richardson brought a Bender model of superoxide dismutase. While comparing these physical models at the meeting, they realized that both proteins use a similar fold, despite having only about 9% sequence identity. This incident<ref name="benderig">PMID: 1271464</ref> was the first recognition of the occurrence of what is now recognized as the immunoglobulin superfamily domain in proteins that are apparently unrelated by sequence.

-	Byron's Bender remained available through the 1990's. Tim Herman, then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.	+	Byron's Bender remained available through the 1990's. [[#Tim_Herman\|Tim Herman]], then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.

	Aside from the importance of the tactile as well as visual input these models provide, another of their great strengths is that they jiggle and vibrate when handled, thereby simulating thermal motion. Too often users of computer models lose sight of the fact that protein molecules in living systems are constantly flexing due to thermal motion.		Aside from the importance of the tactile as well as visual input these models provide, another of their great strengths is that they jiggle and vibrate when handled, thereby simulating thermal motion. Too often users of computer models lose sight of the fact that protein molecules in living systems are constantly flexing due to thermal motion.

Eric Martz: /* Jane S. Richardson */

Eric Martz — Wed, 26 Jun 2019 19:31:44 GMT

Jane S. Richardson

←Older revision		Revision as of 19:31, 26 June 2019
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	Jane S. Richardson's hand drawn ribbon representation of triose phosphate isomerase, published in 1980<ref name="jsr80" />. Image from [https://commons.wikimedia.org/wiki/File:TIM-end_ribbon_shaded.png Wikimedia Commons], under the [https://creativecommons.org/licenses/by/4.0/deed.en Creative Commons Attribution 4.0 International] license.		Jane S. Richardson's hand drawn ribbon representation of triose phosphate isomerase, published in 1980<ref name="jsr80" />. Image from [https://commons.wikimedia.org/wiki/File:TIM-end_ribbon_shaded.png Wikimedia Commons], under the [https://creativecommons.org/licenses/by/4.0/deed.en Creative Commons Attribution 4.0 International] license.
	<br><br>		<br><br>
-	For photos of Jane and more ~~beautiful~~ examples of her drawings, see ''[https://stories.duke.edu/sciences-mother-of-ribbon-diagrams-celebrates-50-years-at-duke Science’s ‘Mother of Ribbon Diagrams’ celebrates 50 years at Duke]''.	+	For photos of Jane Richardson and more examples of her beautiful drawings, see ''[https://stories.duke.edu/sciences-mother-of-ribbon-diagrams-celebrates-50-years-at-duke Science’s ‘Mother of Ribbon Diagrams’ celebrates 50 years at Duke]''.
	</td></tr></table>		</td></tr></table>

Eric Martz: /* Jane S. Richardson */

Eric Martz — Wed, 26 Jun 2019 19:26:08 GMT

Jane S. Richardson

←Older revision		Revision as of 19:26, 26 June 2019
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	Jane S. Richardson's hand drawn ribbon representation of triose phosphate isomerase, published in 1980<ref name="jsr80" />. Image from [https://commons.wikimedia.org/wiki/File:TIM-end_ribbon_shaded.png Wikimedia Commons], under the [https://creativecommons.org/licenses/by/4.0/deed.en Creative Commons Attribution 4.0 International] license.		Jane S. Richardson's hand drawn ribbon representation of triose phosphate isomerase, published in 1980<ref name="jsr80" />. Image from [https://commons.wikimedia.org/wiki/File:TIM-end_ribbon_shaded.png Wikimedia Commons], under the [https://creativecommons.org/licenses/by/4.0/deed.en Creative Commons Attribution 4.0 International] license.
		+	<br><br>
		+	For photos of Jane and more beautiful examples of her drawings, see ''[https://stories.duke.edu/sciences-mother-of-ribbon-diagrams-celebrates-50-years-at-duke Science’s ‘Mother of Ribbon Diagrams’ celebrates 50 years at Duke]''.
	</td></tr></table>		</td></tr></table>

Eric Martz: /* Muffler Pipe */

Eric Martz — Mon, 24 Sep 2018 05:50:44 GMT

Muffler Pipe

←Older revision		Revision as of 05:50, 24 September 2018
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-	Shortly after conceiving the idea for his [[#Byron's Bender\|Bender]], crystallographer Byron Rubin realized that the machine used in Midas Muffler shops to customize automobile tailpipes operated on a similar principle, but at larger scale. He collaborated with the local shop to construct a backbone sculpture of rubredoxin about 5 feet high from stainless steel tailpipe. Rubin's rubredoxin sculpture ~~(not shown<ref>We have been unable to obtain a photograph of this sculpture. If you can provide one, please send it to {{Contact}}.</ref>)~~ won the Chandler competetion at the University of North Carolina in 1973. It stood in the lobby of the Paul M. Gross Chemistry Building at Duke University, Durham NC USA from 1973-2008. Since 2008 it has been in the atrium of the French Family Science Center at Duke.	+	Shortly after conceiving the idea for his [[#Byron's Bender\|Bender]], crystallographer Byron Rubin realized that the machine used in Midas Muffler shops to customize automobile tailpipes operated on a similar principle, but at larger scale. He collaborated with the local shop to construct a backbone sculpture of rubredoxin about 5 feet high from stainless steel tailpipe. Rubin's rubredoxin sculpture won the Chandler competetion at the University of North Carolina in 1973. It stood in the lobby of the Paul M. Gross Chemistry Building at Duke University, Durham NC USA from 1973-2008. Since 2008 it has been in the atrium of the French Family Science Center at Duke.
	{{Clear}}		{{Clear}}

Eric Martz: /* Dorothy Crowfoot Hodgkin */

Eric Martz — Fri, 11 May 2018 19:41:18 GMT

Dorothy Crowfoot Hodgkin

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-	[https://en.wikipedia.org/wiki/Dorothy_Hodgkin Dorothy Crowfoot Hodgkin] (1910-1994) was an eminent and ground-breaking crystallographer, who won the [[Nobel Prizes for 3D Molecular Structure\|1964 Nobel Prize in Chemistry]] for pioneering X-ray diffraction work that included solving the structures of penicillin (1949<ref name="crowfoot-p" />) and vitamin B12 (mid-1950's<ref name="crowfoot-v">PMID:13348621</ref>). She was 69th to win the Nobel in Chemistry, but only [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry the third woman to win it], after Marie Curie and her daughter Irène Joliot-Curie<ref>In 2018, only one additional woman has won the [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry Nobel Prize in Chemistry], making four out of 177: Ada Yonath.</ref>. In 1945, she solved the structure of penicillin. The structure had been controversial prior to her work, published in 1949<ref name="crowfoot-p">PMID:18134678</ref>. In 1971, she was a member of the team solving the structure of insulin<ref name="crowfoot-i">PMID:4932997</ref>. The insulin structure was solved at the time the [[Protein Data Bank]] was being founded, and was not deposited until 1980 as 1ins, superceded by [[4ins]] in 1989<ref>[http://History.Molviz.Org See <i>Earliest Solutions for Macromolecular Crystal Structures</i> at History.MolviZ.Org].</ref>.	+	[https://en.wikipedia.org/wiki/Dorothy_Hodgkin Dorothy Crowfoot Hodgkin]<ref>''Dorothy Hodgkin, a life'' by Georgina Ferry, first published 1998 by Granta Books. 2014 edition by Bloomsbury Reader. 528 pages.</ref> (1910-1994) was an eminent and ground-breaking crystallographer, who won the [[Nobel Prizes for 3D Molecular Structure\|1964 Nobel Prize in Chemistry]] for pioneering X-ray diffraction work that included solving the structures of penicillin (1949<ref name="crowfoot-p" />) and vitamin B12 (mid-1950's<ref name="crowfoot-v">PMID:13348621</ref>). She was 69th to win the Nobel in Chemistry, but only [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry the third woman to win it], after Marie Curie and her daughter Irène Joliot-Curie<ref>In 2018, only one additional woman has won the [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry Nobel Prize in Chemistry], making four out of 177: Ada Yonath.</ref>. In 1945, she solved the structure of penicillin. The structure had been controversial prior to her work, published in 1949<ref name="crowfoot-p">PMID:18134678</ref>. In 1971, she was a member of the team solving the structure of insulin<ref name="crowfoot-i">PMID:4932997</ref>. The insulin structure was solved at the time the [[Protein Data Bank]] was being founded, and was not deposited until 1980 as 1ins, superceded by [[4ins]] in 1989<ref>[http://History.Molviz.Org See <i>Earliest Solutions for Macromolecular Crystal Structures</i> at History.MolviZ.Org].</ref>.

	An excellent 4.5 minute video by Huy Do Duc (Hochschule für Technik und Wirtschaft, Dresden) explains the science behind this model. The video is available at the [https://www.mhs.ox.ac.uk/backfromthedead/exhibition/the-structure-of-penicillin/ Museum of the History of Science] (Oxford, UK).		An excellent 4.5 minute video by Huy Do Duc (Hochschule für Technik und Wirtschaft, Dresden) explains the science behind this model. The video is available at the [https://www.mhs.ox.ac.uk/backfromthedead/exhibition/the-structure-of-penicillin/ Museum of the History of Science] (Oxford, UK).

Eric Martz: /* Dorothy Crowfoot Hodgkin */

Eric Martz — Sat, 05 May 2018 20:53:05 GMT

Dorothy Crowfoot Hodgkin

←Older revision		Revision as of 20:53, 5 May 2018
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-	[https://en.wikipedia.org/wiki/Dorothy_Hodgkin Dorothy Crowfoot Hodgkin] (1910-1994) was an eminent and ground-breaking crystallographer, who won the [[Nobel Prizes for 3D Molecular Structure\|1964 Nobel Prize in Chemistry]] for pioneering X-ray diffraction work that included solving the structures of penicillin (1949<ref name="crowfoot-p" />) and vitamin B12 ~~in the~~ mid-1950's<ref name="crowfoot-v">PMID:13348621</ref>. She was 69th to win the Nobel in Chemistry, but only [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry the third woman to win it], after Marie Curie and her daughter Irène Joliot-Curie<ref>In 2018, only one additional woman has won the [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry Nobel Prize in Chemistry], making four out of 177: Ada Yonath.</ref>. In 1945, she solved the structure of penicillin. The structure had been controversial prior to her work, published in 1949<ref name="crowfoot-p">PMID:18134678</ref>. In 1971, she was a member of the team solving the structure of insulin<ref name="crowfoot-i">PMID:4932997</ref>. The insulin structure was solved at the time the [[Protein Data Bank]] was being founded, and was not deposited until 1980 as 1ins, superceded by [[4ins]] in 1989<ref>[http://History.Molviz.Org See <i>Earliest Solutions for Macromolecular Crystal Structures</i> at History.MolviZ.Org].</ref>.	+	[https://en.wikipedia.org/wiki/Dorothy_Hodgkin Dorothy Crowfoot Hodgkin] (1910-1994) was an eminent and ground-breaking crystallographer, who won the [[Nobel Prizes for 3D Molecular Structure\|1964 Nobel Prize in Chemistry]] for pioneering X-ray diffraction work that included solving the structures of penicillin (1949<ref name="crowfoot-p" />) and vitamin B12 (mid-1950's<ref name="crowfoot-v">PMID:13348621</ref>). She was 69th to win the Nobel in Chemistry, but only [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry the third woman to win it], after Marie Curie and her daughter Irène Joliot-Curie<ref>In 2018, only one additional woman has won the [https://en.wikipedia.org/wiki/List_of_Nobel_laureates_in_Chemistry Nobel Prize in Chemistry], making four out of 177: Ada Yonath.</ref>. In 1945, she solved the structure of penicillin. The structure had been controversial prior to her work, published in 1949<ref name="crowfoot-p">PMID:18134678</ref>. In 1971, she was a member of the team solving the structure of insulin<ref name="crowfoot-i">PMID:4932997</ref>. The insulin structure was solved at the time the [[Protein Data Bank]] was being founded, and was not deposited until 1980 as 1ins, superceded by [[4ins]] in 1989<ref>[http://History.Molviz.Org See <i>Earliest Solutions for Macromolecular Crystal Structures</i> at History.MolviZ.Org].</ref>.

	An excellent 4.5 minute video by Huy Do Duc (Hochschule für Technik und Wirtschaft, Dresden) explains the science behind this model. The video is available at the [https://www.mhs.ox.ac.uk/backfromthedead/exhibition/the-structure-of-penicillin/ Museum of the History of Science] (Oxford, UK).		An excellent 4.5 minute video by Huy Do Duc (Hochschule für Technik und Wirtschaft, Dresden) explains the science behind this model. The video is available at the [https://www.mhs.ox.ac.uk/backfromthedead/exhibition/the-structure-of-penicillin/ Museum of the History of Science] (Oxford, UK).

←Older revision		Revision as of 20:25, 18 February 2021
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	==See Also==		==See Also==
	*[[Byron's Bender]]		*[[Byron's Bender]]
		+	*[[:Category:PDB Art]]
	*[[History of Macromolecular Visualization]]		*[[History of Macromolecular Visualization]]
	*[[Molecular modeling and visualization software]]		*[[Molecular modeling and visualization software]]