B-cell lymphoma protein - Revision history

Michal Harel at 08:14, 30 May 2024

Michal Harel — Thu, 30 May 2024 08:14:35 GMT

←Older revision		Revision as of 08:14, 30 May 2024
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	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.		'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.
	*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.		*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.
-	*'''Bak''' or '''Bcl-2-like-7'' or '''Bcl-2 homologous antagonist/killer''' and '''Bax''' or '''Bcl-2-like-4''' promote apoptosis	+	*'''Bak''' or '''Bcl-2-like-7''' or '''Bcl-2 homologous antagonist/killer''' and '''Bax''' or '''Bcl-2-like-4''' promote apoptosis
	*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.		*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.
	*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.		*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.

Michal Harel at 08:14, 30 May 2024

Michal Harel — Thu, 30 May 2024 08:14:06 GMT

←Older revision		Revision as of 08:14, 30 May 2024
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	<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>		<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]
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Michal Harel at 08:13, 30 May 2024

Michal Harel — Thu, 30 May 2024 08:13:21 GMT

←Older revision		Revision as of 08:13, 30 May 2024
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	<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>		<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]
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	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.		'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.
	*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.		*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.
-	*'''Bak''' or '''Bcl-2-like-7''and '''Bax''' promote apoptosis	+	*'''Bak''' or '''Bcl-2-like-7'' or '''Bcl-2 homologous antagonist/killer''' and '''Bax''' or '''Bcl-2-like-4''' promote apoptosis
	*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.		*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.
	*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.		*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.
-	* ~~'''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''.~~ '''Bcl-2-like-11''' is called '''Bim'''.	+	*'''Bcl-2-like-11''' is called '''Bim'''.
	'''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.		'''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.

Michal Harel at 07:59, 30 May 2024

Michal Harel — Thu, 30 May 2024 07:59:20 GMT

←Older revision		Revision as of 07:59, 30 May 2024
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	<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>		<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]
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Michal Harel at 07:58, 30 May 2024

Michal Harel — Thu, 30 May 2024 07:58:57 GMT

←Older revision		Revision as of 07:58, 30 May 2024
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	<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>		<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]
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	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.		'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.

Michal Harel at 07:55, 30 May 2024

Michal Harel — Thu, 30 May 2024 07:55:39 GMT

←Older revision		Revision as of 07:55, 30 May 2024
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	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]

-	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''. '''Bcl-2''' and '''Bcl-xL''' suppress cell death ~~and~~ '''Bak''' and '''Bax''' promote apoptosis.'''Bcl-xL''' (Bcl-2-like protein 1) known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''. '''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''. '''Bcl-2-like-11''' is called '''Bim'''. '''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.	+	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.
		+	*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.
		+	*'''Bak''' or '''Bcl-2-like-7''and '''Bax''' promote apoptosis
		+	*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.
		+	*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.
		+	* '''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''. '''Bcl-2-like-11''' is called '''Bim'''.
		+	'''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.

	{{Clear}}		{{Clear}}

Michal Harel at 08:50, 20 July 2022

Michal Harel — Wed, 20 Jul 2022 08:50:16 GMT

←Older revision		Revision as of 08:50, 20 July 2022
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	[[Image:Bcl-2_3D.jpg\|left\|200px]]		[[Image:Bcl-2_3D.jpg\|left\|200px]]

-	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins. '''Bcl-2''' and '''Bcl-xL''' suppress cell death and '''Bak''' and '''Bax''' promote apoptosis.'''Bcl-xL''' (Bcl-2-like protein 1) known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''. '''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''. '''Bcl-2-like-11''' is called '''Bim'''. '''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.	+	'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''. '''Bcl-2''' and '''Bcl-xL''' suppress cell death and '''Bak''' and '''Bax''' promote apoptosis.'''Bcl-xL''' (Bcl-2-like protein 1) known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''. '''Bcl-2-like-7''' is called '''Bak''' for '''Bcl-2 homologous antagonist/killer'''. '''Bcl-2-like-4''' is called '''Bax'''. '''Bcl-2-like-11''' is called '''Bim'''. '''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.

	{{Clear}}		{{Clear}}

Michal Harel at 08:58, 2 April 2019

Michal Harel — Tue, 02 Apr 2019 08:58:58 GMT

←Older revision		Revision as of 08:58, 2 April 2019
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	</StructureSection>		</StructureSection>
-	==3D structures of B-cell lymphoma proteins==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Bcl-xL (Bcl-2-like protein 1)
-
-	**[[1maz]], [[1r2d]], [[2b48]], [[4ppi]] – hBcl-xL – human<br />
-	**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
-	**[[2lpc]], [[2m03]], [[2me8]], [[2me9]], [[1lxl]] - hBcl-xL – NMR<br />
-	**[[6bf2]] - hBcl-xL (mutant) – NMR<br />
-	**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
-	**[[2mej]] - hBcl-xL + p53 - NMR<br />
-	**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
-	**[[1ysg]], [[3sp7]], [[3spf]], [[3wiz]], [[4tuh]], [[3zln]], [[3zk6]], [[3zlo]], [[3zlr]], [[4c52]], [[4c5d]], [[2yxj]], [[4qnq]], [[4qvx]] - hBcl-xL + inhibitor<br />
-	**[[2w3l]] – hBcl-xL + quinoline derivative<br />
-	**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
-	**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
-	**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
-	**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
-	**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
-	**[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
-	**[[1pq1]], [[5c3g]] - mBcl-xL residues 1-196 + BIM peptide<br />
-	**[[1af3]] - rBcl-xL soluble domain<br />
-	**[[1bxl]] - Bcl-xL + Bak peptide – Escherichia coli – NMR<br />
-	**[[5twa]] - Bcl-xL + Bak peptide – sponge<br />
-
-	*Bcl-xL complex with BH3 domain peptide
-
-	**[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
-	**[[5fmk]], [[5fmj]] - hBcl-xL + Bak BH3 domain<br />
-	**[[4qve]] - hBcl-xL + BID BH3 domain<br />
-	**[[1g5j]] - hBcl-xL + BAD BH3 peptide <br />
-	**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
-	**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
-	**[[6dcn]] - hBcl-xL + Beclin-1 BH3 domain<br />
-	**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
-	**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
-	**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
-	**[[4a1u]], [[4a1w]] - hBcl-xL + α/β-foldamer BH3 domain<br />
-	**[[3r85]] - hBcl-xL + heme-binding protein BH3 peptide<br />
-	**[[2lp8]] – hBcl-xL + Bcl-2 homologous antagonist/killer BH3 peptide - NMR<br />
-	**[[2m04]] – hBcl-xL (mutant) + Bcl-2 binding component 3 BH3 peptide - NMR<br />
-	**[[5wos]] - Bcl-xL + hBIM BH3 domain – canarypox virus<br />
-	**[[5tzp]] - fpvBcl-xL + BIK BH3 domain – fowlpox virus<br />
-	**[[5tzq]] - fpvBcl-xL + Bmf BH3 domain <br />
-
-	*Bcl-2
-
-	**[[1gjh]], [[1g5m]] – hBcl-2<br />
-	**[[4aq3]], [[4man]], [[5jsn]], [[4ieh]] – hBcl-2 + inhibitor<br />
-	**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
-	**[[5fcg]] – hBcl-2 (mutant) + HBX BH3 domain<br />
-	**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator Bax BH3 domain<br />
-	**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative – NMR
-
-	*Bcl-2-related protein A1 (Bfl-1)
-
-	**[[5whi]] - hBcl-2A1 (mutant) <br />
-	**[[2vm6]] – hBcl-2A1 + hBIM BH3 peptide<br />
-	**[[2vof]] - mBcl-2A1 + Bcl-2 binding component 3 BH3 peptide <br />
-	**[[2vog]] - mBcl-2A1 + Bmf BH3 peptide <br />
-	**[[2voh]] - mBcl-2A1 + Bak BH3 peptide <br />
-	**[[2voi]] - mBcl-2A1 + BID BH3 peptide <br />
-	**[[3mqp]] - hBcl-2A1 + Noxa BH3 peptide <br />
-	**[[5uul]] - hBcl-2A1 + PUMA BH3 peptide <br />
-	**[[5uuk]], [[5uup]] - hBcl-2A1 + Bfl-1 peptide <br />
-	**[[4zeq]] - hBcl-2A1 + BID BH3 peptide <br />
-
-	*Bcl-3
-
-	**[[1k1a]], [[1k1b]] – hBcl-3 ankyrin repeat domain <br />
-
-	*Bcl-6
-
-	**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
-	**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
-	**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
-	**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
-	**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
-	**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
-	**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
-	**[[2lce]] – hBcl-6 zinc fingers 2-3 residues 540-602 - NMR<br />
-	**[[2yrm]], [[2eos]] – hBcl-6 zinc finger-C2H2 residues 515-544 - NMR<br />
-	**[[2en2]] – hBcl-6 zinc finger-C2H2 residues 598-626 - NMR<br />
-
-	*Bcl-9
-
-	**[[3sl9]] – hBcl-9 residues 344-396 + catenin β-1<br />
-	**[[2gl7]] – hBcl-9 residues 344-396 + catenin β-1 + transcription factor 7-like<br />
-
-	*Bcl-10
-
-	**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
-	**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
-	**[[6gk2]] – hBcl-10 CARD domain + MALTI death domain – Cryo EM<br />
-
-	*Bcl-W (Bcl-2-like protein 2)
-
-	**[[1o0l]], [[1mk3]], [[2y6w]] – hBcl-W (mutant) <br />
-	**[[1zy3]], [[4cim]] - hBcl-W (mutant) + BID BH3 peptide<br />
-	**[[4k5a]], [[4k5b]] - Bcl-W (mutant) + ankyrin repeat - bovine<br />
-	**[[4cin]] - hBcl-W + BH3 peptide<br />
-
-	*Bcl-2-like protein 4 (Bax)
-
-	**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
-	**[[4bd8]], [[5w60]], [[5w61]] – hBax (mutant) <br />
-	**[[2lr1]] - hBax + VMIA peptide<br />
-	**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
-	**[[2k7w]] – hBax + BIM BH3 peptide - NMR<br />
-	**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
-	**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
-	**[[5w5z]], [[5w5x]] – hBax (mutant) + antibody<br />
-
-	*Bcl-2-like protein 5
-
-	**[[3i1h]] - hBcl-2-L-5 + hBak<br />
-
-	*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)
-
-	**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBak<br />
-	**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
-	**[[4u2v]] – hBak/GFP<br />
-	**[[3qbr]] - hBak + sjA<br />
-	**[[2xpx]] - hBak fragment + BHRF1<br />
-	**[[5vwx]], [[5vwy]], [[5vwz]], [[5vx0]] - hBak + BIM BH3 domain<br />
-	**[[5vwv]] - hBak (mutant)+ BIM BH3 domain<br />
-	**[[2m5b]] - hBak + BID BH3 domain - NMR<br />
-
-	*Bcl-2-like protein 10
-
-	**[[2kua]] – mBcl-2-L-10<br />
-	**[[4b4s]] - hBcl-2-L-10 + hBIM BH3 peptide<br />
-
-	*Bcl-2-like protein 11 (BIM)
-
-	**[[2nl9]] – hBIM + Mcl-1<br />
-
-	*Mcl-1 (Bcl-2-like protein 3)
-
-	**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
-	**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
-	**[[3mk8]] - hMcl-1 residues 174-324<br />
-	**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
-	**[[4wms]] - hMcl-1/MBP (mutant) <br />
-	**[[5lof]] - hMcl-1/MBP + inhibitor<br />
-	**[[4wmx]], [[4wmw]], [[4wmv]] - hMcl-1/MBP + ligand<br />
-	**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
-	**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
-	**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]] - hMcl-1 residues 174-324 + inhibitor<br />
-	**[[5uum]] - hMcl-1 residues 174-324 + FS2 peptide <br />
-	**[[6mbd]] - hMcl-1 residues 174-324 + DM1 peptide <br />
-	**[[6mbe]] - hMcl-1 residues 174-324 + DM7 peptide <br />
-	**[[5c3f]] - hMcl-1 residues 174-324 + BIB MM <br />
-	**[[5mes]], [[5mev]], [[6fs0]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
-	**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />
-
-	*Mcl-1 complex with BH3 domain peptide
-
-	**[[2nla]], [[4g35]] – rMcl-1 fragment + NoxaB BH3 domain<br />
-	**[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
-	**[[2roc]] - mMcl-1 fragment + Puma BH3 domain<br />
-	**[[3kz0]] - hMcl-1 + MB7 BH3 domain<br />
-	**[[3pk1]] – hMcl-1 fragment + hBax BH3 domain<br />
-	**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
-	**[[4bpj]], [[4bpi]] - hMcl-1 fragment + Puma BH3 peptide <br />
-	**[[5c6h]] - hMcl-1 fragment + Mule BH3 peptide <br />
-	**[[5w89]], [[5w8f]], [[3kj0]], [[3kj1]], [[3kj2]], [[3io9]], [[3d7v]], [[2pqk]], [[5vx2]] - hMcl-1 fragment + BIM BH3 peptide <br />
-	**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide - NMR <br />
-
-	*M11
-
-	**[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
-	**[[2jby]] – MvM11L + Bcl-2 homologous antagonist/killer <br />
-	**[[3dvu]], [[3bl2]], [[4mi8]] – M11 + Beclin-1 – Murid herpesvirus<br />
-
-	*N1L
-
-	**[[2i39]] – VvN1L – Vaccinia virus<br />
-	**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
-	}}

	==References==		==References==

Michal Harel at 08:53, 2 April 2019

Michal Harel — Tue, 02 Apr 2019 08:53:40 GMT

←Older revision		Revision as of 08:53, 2 April 2019
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	[[Image:signal transduction.jpg\|left\|500px]]		[[Image:signal transduction.jpg\|left\|500px]]
	{{Clear}}		{{Clear}}
		+
		+	==3D structures of B-cell lymphoma proteins==
		+	[[B-cell lymphoma proteins 3D structures]]
		+
	</StructureSection>		</StructureSection>
	==3D structures of B-cell lymphoma proteins==		==3D structures of B-cell lymphoma proteins==
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	**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />		**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]], [[2o21]], [[2o22]], [[2o2f]] - hBcl-xL + sulfonamide derivative – NMR<br />
	**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />		**[[3qkd]], [[4ehr]] - hBcl-xL + sulfonamide derivative<br />
-	**[[2pon]] - hBcl-xL + Beclin-1- NMR~~<br />~~	+	**[[2pon]] - hBcl-xL + Beclin-1 residues 1-23 - NMR<br />
-	**[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />	+
	**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />		**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
	**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />		**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant) <br />
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	**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />		**[[5b1z]] - hBcl-xL + BHX BH3 domain<br />
	**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />		**[[4z9v]] - hBcl-xL + TCTP BH3 domain<br />
		+	**[[6dcn]] - hBcl-xL + Beclin-1 BH3 domain<br />
		+	**[[2p1l]] - hBcl-xL (mutant) + Beclin-1 BH3 domain<br />
	**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />		**[[2yq6]], [[4qvf]], [[4yk9]], [[3fdl]], [[5agx]], [[4yj4]], [[3io8]], [[2yq7]], [[5vx3]], [[5agw]] - hBcl-xL + BIM BH3 domain<br />
	**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />		**[[2yj1]], [[4bpk]], [[4hnj]] - hBcl-xL + α/β-Puma BH3 domain<br />
Line 108:		Line 113:

	**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />		**[[3e4u]], [[1r28]], [[1r29]], [[4u2m]] – hBcl-6 BTB domain <br />
-	**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]] – hBcl-6 BTB domain + inhibitor<br />	+	**[[3lbz]], [[5mw6]], [[5mw2]], [[5mwd]], [[5n1x]], [[5n1z]], [[5n20]], [[5n21]], [[5x4m]], [[5x4n]], [[5x4o]], [[5x4p]], [[5x9o]], [[5x9p]], [[5x4o]], [[5x4q]], [[6ew8]], [[6ew7]], [[6ew6]], [[6c3n]] – hBcl-6 BTB domain + inhibitor<br />
		+	**[[6cq1]], [[6c3l]] – hBcl-6 BTB domain (mutant) + inhibitor<br />
	**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />		**[[4cp3]] – hBcl-6 BTB domain + antibiotic<br />
	**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />		**[[3bim]] – hBcl-6 BTB domain (mutant) + Bcl-6 corepressor<br />
	**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />		**[[5h7g]], [[5h7h]] – hBcl-6 BTB domain + F1324 peptide<br />
	**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />		**[[1r2b]] – hBcl-6 BTB domain + SMRT peptide<br />
-	**[[2lce]] – hBcl-6 zinc fingers 2-3 - NMR<br />	+	**[[2lce]] – hBcl-6 zinc fingers 2-3 residues 540-602 - NMR<br />
		+	**[[2yrm]], [[2eos]] – hBcl-6 zinc finger-C2H2 residues 515-544 - NMR<br />
		+	**[[2en2]] – hBcl-6 zinc finger-C2H2 residues 598-626 - NMR<br />

	*Bcl-9		*Bcl-9

-	**[[3sl9]] – hBcl-9 residues 344-396 + catenin ~~beta~~-1<br />	+	**[[3sl9]] – hBcl-9 residues 344-396 + catenin β-1<br />
		+	**[[2gl7]] – hBcl-9 residues 344-396 + catenin β-1 + transcription factor 7-like<br />

	*Bcl-10		*Bcl-10
Line 123:		Line 132:
	**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />		**[[2mb9]] – hBcl-10 CARD domain (mutant) – NMR<br />
	**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />		**[[6bze]] – hBcl-10 CARD domain – Cryo EM<br />
		+	**[[6gk2]] – hBcl-10 CARD domain + MALTI death domain – Cryo EM<br />

	*Bcl-W (Bcl-2-like protein 2)		*Bcl-W (Bcl-2-like protein 2)
Line 134:		Line 144:

	**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />		**[[4bd7]], [[4s0o]], [[4s0p]] - hBax <br />
-	**[[4bd8]] – hBax (mutant) <br />	+	**[[4bd8]], [[5w60]], [[5w61]] – hBax (mutant) <br />
	**[[2lr1]] - hBax + VMIA peptide<br />		**[[2lr1]] - hBax + VMIA peptide<br />
	**[[4bd6]] – hBax (mutant) + BH3 peptide<br />		**[[4bd6]] – hBax (mutant) + BH3 peptide<br />
Line 140:		Line 150:
	**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />		**[[4zie]], [[4zif]], [[4zig]], [[4zih]], [[4zii]], [[5vww]] – hBax (mutant) + BIM BH3 peptide<br />
	**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />		**[[4bd2]] – hBax (mutant) + BID BH3 peptide<br />
		+	**[[5w5z]], [[5w5x]] – hBax (mutant) + antibody<br />

	*Bcl-2-like protein 5		*Bcl-2-like protein 5
Line 168:		Line 179:

	**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />		**[[1wsx]] – mMcl-1 residues 152-308 - NMR<br />
-	**[[3mk8]] - hMcl-1 ~~fragment~~<br />	+	**[[6dm8]] - mMcl-1/MBP + inhibitor<br />
-	**[[2mhs]] - hMcl-1 ~~fragment~~ (mutant)<br />	+	**[[3mk8]] - hMcl-1 residues 174-324<br />
		+	**[[2mhs]] - hMcl-1 residues 174-324 (mutant)<br />
	**[[4wms]] - hMcl-1/MBP (mutant) <br />		**[[4wms]] - hMcl-1/MBP (mutant) <br />
	**[[5lof]] - hMcl-1/MBP + inhibitor<br />		**[[5lof]] - hMcl-1/MBP + inhibitor<br />
Line 175:		Line 187:
	**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />		**[[4wmu]], [[4wmt]] - hMcl-1/MBP (mutant) + ligand<br />
	**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />		**[[4wgi]] - hMcl-1/MBP (mutant) + macrolactam<br />
-	**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]] - hMcl-1 ~~fragment~~ + inhibitor<br />	+	**[[3wix]], [[3wiy]], [[4oq5]], [[4oq6]], [[4hw2]], [[4hw3]], [[4hw4]], [[4wmr]], [[4zbf]], [[4zbi]], [[5fc4]], [[5fdo]], [[5fdr]], [[5iez]], [[5if4]], [[5jsb]], [[5ku9]], [[5vkc]], [[6b4l]], [[6b4u]], [[6bw2]], [[6bw8]], [[6fs1]], [[6fs2]] - hMcl-1 residues 174-324 + inhibitor<br />
-	**[[5uum]] - hMcl-1 ~~fragment~~ + FS2 peptide <br />	+	**[[5uum]] - hMcl-1 residues 174-324 + FS2 peptide <br />
-	**[[5c3f]] - hMcl-1 ~~fragment~~ + BIB MM <br />	+	**[[6mbd]] - hMcl-1 residues 174-324 + DM1 peptide <br />
-	**[[5mes]], [[5mev]] - hMcl-1 ~~fragment~~ + inhibitor + antibody<br />	+	**[[6mbe]] - hMcl-1 residues 174-324 + DM7 peptide <br />
		+	**[[5c3f]] - hMcl-1 residues 174-324 + BIB MM <br />
		+	**[[5mes]], [[5mev]], [[6fs0]] - hMcl-1 residues 153-221 + inhibitor + antibody<br />
		+	**[[6fs0]] - hMcl-1 residues 174-324 + inhibitor + antibody<br />

	*Mcl-1 complex with BH3 domain peptide		*Mcl-1 complex with BH3 domain peptide

Michal Harel at 08:27, 2 April 2019

Michal Harel — Tue, 02 Apr 2019 08:27:47 GMT

←Older revision		Revision as of 08:27, 2 April 2019
Line 147:		Line 147:
	*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)		*Bcl-2-like protein 7 (Bak, Bcl-2 homologous antagonist/killer)

-	**[[2yv6]], 2imt, 2jcn, 2ims – hBak<br />	+	**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBak<br />
	**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />		**[[5fmi]], [[4u2u]], [[5vx1]] – hBak (mutant)<br />
	**[[4u2v]] – hBak/GFP<br />		**[[4u2v]] – hBak/GFP<br />