Brachyury - Revision history

Michal Harel at 10:49, 3 November 2022

Michal Harel — Thu, 03 Nov 2022 10:49:15 GMT

←Older revision		Revision as of 10:49, 3 November 2022
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	[[5qsi]] - hBra T domain + aniline derivative <br />		[[5qsi]] - hBra T domain + aniline derivative <br />
	[[5qsc]], [[6zu8]] - hBra T domain + inhibitor <br />		[[5qsc]], [[6zu8]] - hBra T domain + inhibitor <br />
		+	[[7zl2]], [[8a7n]], [[8a10]] - hBra T domain + ligand<br />
	[[1xbr]] - Bra T domain + DNA - frog<br />		[[1xbr]] - Bra T domain + DNA - frog<br />
	<br />		<br />

Michal Harel at 09:08, 13 May 2021

Michal Harel — Thu, 13 May 2021 09:08:40 GMT

←Older revision		Revision as of 09:08, 13 May 2021
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	[[5qsf]] - hBra T domain + phenol derivative <br />		[[5qsf]] - hBra T domain + phenol derivative <br />
	[[5qsi]] - hBra T domain + aniline derivative <br />		[[5qsi]] - hBra T domain + aniline derivative <br />
-	[[5qsc]] - hBra T domain + inhibitor <br />	+	[[5qsc]], [[6zu8]] - hBra T domain + inhibitor <br />
	[[1xbr]] - Bra T domain + DNA - frog<br />		[[1xbr]] - Bra T domain + DNA - frog<br />
	<br />		<br />

Michal Harel at 06:48, 28 June 2020

Michal Harel — Sun, 28 Jun 2020 06:48:50 GMT

←Older revision		Revision as of 06:48, 28 June 2020
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	[[6f59]] - hBra T domain (mutant) + DNA <br />		[[6f59]] - hBra T domain (mutant) + DNA <br />
	[[5qrf]], [[5qrg]], [[5qrk]] - hBra T domain + pyrazole derivative <br />		[[5qrf]], [[5qrg]], [[5qrk]] - hBra T domain + pyrazole derivative <br />
-	[[5qrh]], [[5qri]] - hBra T domain + piperazine derivative <br />	+	[[5qrh]], [[5qri]], [[5qrv]], [[5qry]], [[5qs7]], [[5qsg]], [[5qsj]] - hBra T domain + piperazine derivative <br />
-	[[5qrp]], [[5qrq]] - hBra T domain + piperidine derivative <br />	+	[[5qrp]], [[5qrq]], [[5qs5]], [[5qsb]], [[5qsh]] - hBra T domain + piperidine derivative <br />
-	[[5qrj]], [[5qrr]] - hBra T domain + morpholine derivative <br />	+	[[5qrj]], [[5qrr]], [[5qs0]] - hBra T domain + morpholine derivative <br />
-	[[5qrl]], [[5qro]] - hBra T domain + pyridine derivative <br />	+	[[5qrl]], [[5qro]], [[5qs6]], [[5qs8]], [[5qse]], [[5qt0]] - hBra T domain + pyridine derivative <br />
		+	[[5qsd]] - hBra T domain + pyrimidine derivative <br />
	[[5qrm]] - hBra T domain + oxazole derivative <br />		[[5qrm]] - hBra T domain + oxazole derivative <br />
		+	[[5qrw]] - hBra T domain + imidazole derivative <br />
		+	[[5qs1]], [[5qs4]], [[5qs9]] - hBra T domain + thiazole derivative <br />
	[[5qrn]] - hBra T domain + pyrrolidine derivative <br />		[[5qrn]] - hBra T domain + pyrrolidine derivative <br />
-	[[5qrs]] - hBra T domain + carboxamide derivative <br />	+	[[5qrs]], [[5qrz]], [[5qsl]] - hBra T domain + carboxamide derivative <br />
	[[5qrt]] - hBra T domain + ethanamide derivative <br />		[[5qrt]] - hBra T domain + ethanamide derivative <br />
	[[5qru]] - hBra T domain + glycinamide derivative <br />		[[5qru]] - hBra T domain + glycinamide derivative <br />
		+	[[5qs3]] - hBra T domain + acetamide derivative <br />
		+	[[5qrx]], [[5qsa]] - hBra T domain + benzoate derivative <br />
		+	[[5qsk]] - hBra T domain + acetate derivative <br />
		+	[[5qs2]] - hBra T domain + thiourea derivative <br />
		+	[[5qsf]] - hBra T domain + phenol derivative <br />
		+	[[5qsi]] - hBra T domain + aniline derivative <br />
		+	[[5qsc]] - hBra T domain + inhibitor <br />
	[[1xbr]] - Bra T domain + DNA - frog<br />		[[1xbr]] - Bra T domain + DNA - frog<br />
	<br />		<br />

Michal Harel at 10:31, 25 June 2020

Michal Harel — Thu, 25 Jun 2020 10:31:28 GMT

←Older revision		Revision as of 10:31, 25 June 2020
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	=Introduction=		=Introduction=

-	Two well-known orthologues of the <i>Homo sapiens</i> T protein are present in mice (Brachyury) and <i>Xenopus laevis</i> (Xbra). The homologue of T in mice, Brachyury, was the first T-box crystal structure to be determined.	+	Two well-known orthologues of the <i>Homo sapiens</i> '''T protein''' or '''T-box transcription factor T''' are present in mice ('''Brachyury''') and <i>Xenopus laevis</i> ('''Xbra'''). The homologue of T in mice, Brachyury, was the first T-box crystal structure to be determined.
	=Crystal structure ([[1xbr]])=		=Crystal structure ([[1xbr]])=

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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[6f58]] - hBra residues 39-224 + DNA - human<br />	+	[[6f58]] - hBra T domain residues 39-224 + DNA - human<br />
	[[1h6f]] - hBra residues 101-291 + DNA <br />		[[1h6f]] - hBra residues 101-291 + DNA <br />
-	[[6f59]] - hBra (mutant) ~~residues 39-224~~ + DNA <br />	+	[[6f59]] - hBra T domain (mutant) + DNA <br />
-	[[1xbr]] - Bra T domain ~~residues 39-222~~ + DNA - frog<br />	+	[[5qrf]], [[5qrg]], [[5qrk]] - hBra T domain + pyrazole derivative <br />
		+	[[5qrh]], [[5qri]] - hBra T domain + piperazine derivative <br />
		+	[[5qrp]], [[5qrq]] - hBra T domain + piperidine derivative <br />
		+	[[5qrj]], [[5qrr]] - hBra T domain + morpholine derivative <br />
		+	[[5qrl]], [[5qro]] - hBra T domain + pyridine derivative <br />
		+	[[5qrm]] - hBra T domain + oxazole derivative <br />
		+	[[5qrn]] - hBra T domain + pyrrolidine derivative <br />
		+	[[5qrs]] - hBra T domain + carboxamide derivative <br />
		+	[[5qrt]] - hBra T domain + ethanamide derivative <br />
		+	[[5qru]] - hBra T domain + glycinamide derivative <br />
		+	[[1xbr]] - Bra T domain + DNA - frog<br />
	<br />		<br />
	</StructureSection>		</StructureSection>

Michal Harel at 08:09, 16 April 2019

Michal Harel — Tue, 16 Apr 2019 08:09:39 GMT

←Older revision		Revision as of 08:09, 16 April 2019
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	For additional information, see: [[Transcription and RNA Processing]]		For additional information, see: [[Transcription and RNA Processing]]

-	== 3D Structures of brachyury ==	+	= 3D Structures of brachyury =

	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

Michal Harel at 08:08, 16 April 2019

Michal Harel — Tue, 16 Apr 2019 08:08:51 GMT

←Older revision		Revision as of 08:08, 16 April 2019
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	==Additional Resources==		==Additional Resources==
	For additional information, see: [[Transcription and RNA Processing]]		For additional information, see: [[Transcription and RNA Processing]]
		+
		+	== 3D Structures of brachyury ==
		+
		+	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
		+
		+	[[6f58]] - hBra residues 39-224 + DNA - human<br />
		+	[[1h6f]] - hBra residues 101-291 + DNA <br />
		+	[[6f59]] - hBra (mutant) residues 39-224 + DNA <br />
		+	[[1xbr]] - Bra T domain residues 39-222 + DNA - frog<br />
	<br />		<br />
	</StructureSection>		</StructureSection>

Joel L. Sussman at 11:27, 19 October 2017

Joel L. Sussman — Thu, 19 Oct 2017 11:27:06 GMT

←Older revision		Revision as of 11:27, 19 October 2017
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-	<StructureSection load='' size='400' side='right' scene= caption='T protein complex with DNA (PDB code [[1xbr]])'>	+	<StructureSection load='1xbr' size='400' side='right' scene= caption='T protein complex with DNA (PDB code [[1xbr]])'>

	=Introduction=		=Introduction=

Joel L. Sussman at 11:26, 19 October 2017

Joel L. Sussman — Thu, 19 Oct 2017 11:26:48 GMT

←Older revision		Revision as of 11:26, 19 October 2017
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-	<StructureSection load='~~1xbr~~' size='400' side='right' scene= caption='T protein complex with DNA (PDB code [[1xbr]])'>	+	<StructureSection load='' size='400' side='right' scene= caption='T protein complex with DNA (PDB code [[1xbr]])'>

	=Introduction=		=Introduction=

Michal Harel at 21:10, 18 October 2017

Michal Harel — Wed, 18 Oct 2017 21:10:37 GMT

←Older revision		Revision as of 21:10, 18 October 2017
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	==Reference==		==Reference==
	<ref group="xtra">PMID:009349824</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>		<ref group="xtra">PMID:009349824</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
		+	[[Category:Topic Page]]

Michal Harel at 11:44, 28 January 2016

Michal Harel — Thu, 28 Jan 2016 11:44:44 GMT

←Older revision		Revision as of 11:44, 28 January 2016
Line 1:		Line 1:
-	<StructureSection load='1xbr' size='400' side='right' scene= caption=''>	+	<StructureSection load='1xbr' size='400' side='right' scene= caption='T protein complex with DNA (PDB code [[1xbr]])'>

	=Introduction=		=Introduction=