Bromodomain-containing protein - Revision history

Michal Harel at 06:43, 2 June 2024

Michal Harel — Sun, 02 Jun 2024 06:43:57 GMT

←Older revision		Revision as of 06:43, 2 June 2024
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	*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]]		*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]]
	*'''BRD7''' promotes colorectal cancer by regulating the ubiquitin-proteasome-dependent stabilisation of c-Myc protein<ref>PMID:34109174</ref>.		*'''BRD7''' promotes colorectal cancer by regulating the ubiquitin-proteasome-dependent stabilisation of c-Myc protein<ref>PMID:34109174</ref>.
		+	*'''BRD9''' has a role in activation of interferon-stimulated genes<ref>PMID:34983841</ref>.

	== Disease ==		== Disease ==

Michal Harel at 06:41, 2 June 2024

Michal Harel — Sun, 02 Jun 2024 06:41:05 GMT

←Older revision		Revision as of 06:41, 2 June 2024
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	*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>.		*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>.
	*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]]		*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]]
		+	*'''BRD7''' promotes colorectal cancer by regulating the ubiquitin-proteasome-dependent stabilisation of c-Myc protein<ref>PMID:34109174</ref>.

	== Disease ==		== Disease ==

Michal Harel at 10:32, 30 May 2024

Michal Harel — Thu, 30 May 2024 10:32:23 GMT

←Older revision		Revision as of 10:32, 30 May 2024
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	*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.		*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.
	*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>.		*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>.
-	For detalis on BRD3 see [[Human bromodomain containing protein 3]]	+	*'''BRD3''' and '''BRD4''' regulate skeletal myogenesis<ref>PMID:28733670</ref>. For detalis on BRD3 see [[Human bromodomain containing protein 3]]

	== Disease ==		== Disease ==

Michal Harel at 10:28, 30 May 2024

Michal Harel — Thu, 30 May 2024 10:28:30 GMT

←Older revision		Revision as of 10:28, 30 May 2024
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	'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>.		'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>.
	*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.		*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.
-		+	*'''BRD2''' promotes spatial mixing and compartmentalisation of chromatin<ref>PMID:35410381</ref>.
	For detalis on BRD3 see [[Human bromodomain containing protein 3]]		For detalis on BRD3 see [[Human bromodomain containing protein 3]]

Michal Harel at 10:23, 30 May 2024

Michal Harel — Thu, 30 May 2024 10:23:56 GMT

←Older revision		Revision as of 10:23, 30 May 2024
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	'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>.		'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>.
		+	*'''BRD1''' is essential for normal brain development<ref>PMID:35941107</ref>.

	For detalis on BRD3 see [[Human bromodomain containing protein 3]]		For detalis on BRD3 see [[Human bromodomain containing protein 3]]

Michal Harel at 08:14, 18 April 2019

Michal Harel — Thu, 18 Apr 2019 08:14:12 GMT

←Older revision		Revision as of 08:14, 18 April 2019
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	</StructureSection>		</StructureSection>
-	== 3D Structures of bromodomain-containing protein ==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*Bromodomain-containing protein 1
-
-	**[[3lyi]] – hBRD1 PWWP domain residues 925-1049 - human<br />
-	**[[2ku3]] – hBRD1 PHD1 zinc finger domain residues 208-269 - NMR<br />
-	**[[2lq6]] – hBRD1 PHD2 zinc finger domain residues 317-394 (mutant) - NMR<br />
-	**[[3l43]] – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR<br />
-	**[[3rcw]], [[4z02]] – hBRD1 bromodomain residues 555-688<br />
-	**[[5pwb]], [[5pwa]], [[5pw9]], [[5pw8]], [[5pw7]], [[5pw6]], [[5pw5]], [[5pw4]], [[5pw3]], [[5pw2]], [[5pw1]], [[5pw0]], [[5pvz]], [[5pvy]], [[5pvx]], [[5pvw]], [[5pvv]], [[5pvu]], [[5pvt]], [[5pvs]], [[5pvr]], [[5pvq]], [[5pvp]], [[5pvo]], [[5pvn]], [[5pvm]], [[5pvl]], [[5pvk]], [[5pvj]], [[5pvi]], [[5pvh]], [[5pvg]], [[5pvf]], [[5pve]], [[5pvd]], [[5pvc]], [[5pvb]], [[5pva]], [[5pv9]], [[5pv8]], [[5pv7]], [[5pv6]], [[5pv5]], [[5pv4]], [[5pv3]], [[5pv2]], [[5pv1]], [[5pv0]], [[5puz]], [[5puy]], [[5pux]], [[5puw]], [[5puv]], [[5puu]], [[5put]], [[5pus]], [[5pur]], [[5puq]], [[5pup]], [[5pun]], [[5pum]], [[5puo]], [[5pul]], [[5puk]], [[5puj]], [[5pui]], [[5puh]], [[5pug]], [[5puf]], [[5pue]], [[5pud]], [[5puc]], [[5pub]], [[5pua]], [[5pu9]], [[5pu8]], [[5pu7]], [[5pu6]], [[5pu5]], [[5pu4]], [[5pu3]], [[5pu2]], [[5pu1]], [[5pu0]], [[5ptz]], [[5pty]], [[5ptx]], [[5ptw]], [[5ptv]], [[5ptu]], [[5pts]], [[5ptt]], [[5ptr]], [[5ptq]], [[5ptp]], [[5pto]], [[5ptn]], [[5ptm]], [[5ptl]], [[5ptk]], [[5ptj]], [[5pth]], [[5ptg]], [[5ptf]], [[5pte]], [[5ptd]], [[5ptc]], [[5ptb]], [[5pta]], [[5pt9]], [[5pt8]], [[5pt7]], [[5pt0]], [[5pt1]], [[5pt2]], [[5pt3]], [[5pt4]], [[5pt5]], [[5pt6]], [[5pnx]], [[5pq0]], [[5pq1]], [[5pq2]], [[5pq3]], [[5pq4]], [[5pq5]], [[5pq6]], [[5pq7]], [[5pq8]], [[5pq9]], [[5pqa]], [[5pqb]], [[5pqc]], [[5pqd]], [[5pqe]], [[5pqf]], [[5pqg]], [[5pqh]], [[5pqi]], [[5pqj]], [[5pqk]], [[5pql]], [[5pqm]], [[5pqn]], [[5pqo]], [[5pqp]], [[5pqq]], [[5pqr]], [[5pqs]], [[5pqt]], [[5pqu]], [[5pqv]], [[5pqw]], [[5pqx]], [[5pqy]], [[5pqz]], [[5pr0]], [[5pr1]], [[5pr2]], [[5pr3]], [[5pr4]], [[5pr5]], [[5pr6]], [[5pr7]], [[5pr8]], [[5pr9]], [[5pra]], [[5prb]], [[5prc]], [[5prd]], [[5pre]], [[5prf]], [[5prg]], [[5prh]], [[5pri]], [[5prj]], [[5prk]], [[5prl]], [[5prm]], [[5prn]], [[5pro]], [[5prp]], [[5prq]], [[5prr]], [[5prs]], [[5prt]], [[5pru]], [[5prv]], [[5prw]], [[5prx]], [[5pry]], [[5prz]], [[5ps0]], [[5ps1]], [[5ps2]], [[5ps3]], [[5ps4]], [[5ps5]], [[5ps6]], [[5ps7]], [[5ps8]], [[5ps9]], [[5psa]], [[5psb]], [[5psc]], [[5psd]], [[5pse]], [[5psf]], [[5psg]], [[5psh]], [[5psi]], [[5psj]], [[5psk]], [[5psl]], [[5psm]], [[5psn]], [[5pso]], [[5psp]], [[5psq]], [[5psr]], [[5pss]], [[5pst]], [[5psu]], [[5psv]], [[5psw]], [[5psx]], [[5psy]], [[5psz]] - hBRD1 residues 555-668 (mutant)<br />
-	**[[5n49]] – hBRD1 bromodomain + inhibitor<br />
-	**[[5pny]], [[5pnz]], [[5po0]], [[5po1]], [[5po2]], [[5po3]], [[5po4]], [[5po5]], [[5po6]], [[5po7]], [[5po8]], [[5po9]], [[5poa]], [[5pob]], [[5poc]], [[5pod]], [[5poe]], [[5pof]], [[5pog]], [[5poh]], [[5poi]], [[5poj]], [[5pok]], [[5pol]], [[5pom]], [[5pon]], [[5poo]], [[5pop]], [[5poq]], [[5por]], [[5pos]], [[5pot]], [[5pou]], [[5pov]], [[5pow]], [[5pox]], [[5poy]], [[5poz]], [[5pp0]], [[5pp1]], [[5pp2]], [[5pp3]], [[5pp4]], [[5pp5]], [[5pp6]], [[5pp7]], [[5pp8]], [[5pp9]], [[5ppa]], [[5ppb]], [[5ppc]], [[5ppd]], [[5ppe]], [[5ppf]], [[5ppg]], [[5pph]], [[5ppi]], [[5ppj]], [[5ppk]], [[5ppl]], [[5ppm]], [[5ppn]], [[5ppo]], [[5ppp]], [[5ppq]], [[5ppr]], [[5pps]], [[5ppt]], [[5ppu]], [[5ppv]], [[5ppw]], [[5ppx]], [[5ppy]], [[5ppz]] – hBRD1 bromodomain (mutant) + inhibitor<br />
-	**[[5ame]] – hBRD1 bromodomain+PHD (mutant) + piperazine derivative<br />
-	**[[5amf]] – hBRD1 bromodomain+PHD (mutant) + indazole derivative<br />
-	**[[5fg6]] – hBRD1 bromodomain+PHD + probe<br />
-	**[[4z02]] – hBRD1 PWWP domain + quinoline derivative<br />
-
-	*Bromodomain-containing protein 2
-
-	**[[1x0j]], [[2dvv]] – hBRD2 bromodomain 1<br />
-	**[[5hel]], [[5hem]], [[5hen]], [[5hfq]] – hBRD2 bromodomain 1 (mutant)<br />
-	**[[2g4a]] – hBRD2 residues 1-116 - NMR<br />
-	**[[6cui]] – hBRD2 residues 621-750 - NMR<br />
-	**[[5ibn]] – hBRD2 bromodomain 2 <br />
-	**[[4qeu]], [[5dfb]] – hBRD2 bromodomain 2 (mutant)<br />
-
-	*Bromodomain-containing protein 2 complex
-
-	**[[2dvq]], [[2dvr]], [[2dvs]], [[2e3k]] – hBRD2 bromodomain 1 + histone H4 peptide<br />
-	**[[3oni]] – hBRD2 residues 224-335 + inhibitor<br />
-	**[[3aqa]], [[2ydw]], [[2yek]], [[4a9e]], [[4a9f]], [[4a9h]], [[4a9i]], [[4a9j]], [[4a9m]], [[4a9n]], [[4a9o]], [[4alh]], [[4akn]], [[4alg]], [[4uyf]], [[4uyg]], [[4uyh]] – hBRD2 N-terminal bromodomain + inhibitor<br />
-	**[[4mr5]], [[4mr6]], [[4j1p]], [[5ig6]], [[5ek9]], [[5dw1]], [[5xhk]], [[5xhe]], [[5u6v]], [[5n2l]], [[6mo7]], [[6mo8]], [[6mo9]], [[6moa]] – hBRD2 bromodomain 2 + inhibitor<br />
-	**[[5o3i]], [[5o3h]], [[5o3g]], [[5o3f]], [[5o3e]], [[5o3d]], [[5o3c]], [[5o3b]], [[5o3a]], [[5o39]], [[5o38]] – hBRD2 bromodomain 2 (mutant) + inhibitor<br />
-	**[[5u5s]] – hBRD2 bromodomain 2 + STAT3 peptide - NMR<br />
-	**[[5bt5]] – hBRD2 bromodomain 2 + probe<br />
-	**[[4qev]], [[4qew]] – hBRD2 bromodomain 2 (mutant) + probe<br />
-	**[[5dfc]], [[5dfd]] – hBRD2 bromodomain 2 (mutant) + ligand<br />
-
-	*Bromodomain-containing protein 3
-
-	**[[2nxb]] – hBRD3 bromodomain 1<br />
-	**[[2yw5]] – hBRD3 bromodomain 1 - NMR<br />
-	**[[3s91]], [[3s92]] – hBRD3 bromodomain 1 + inhibitor<br />
-	**[[2l5e]] – mBRD3 bromodomain 1 + GATA-1 C-terminal – mouse - NMR<br />
-	**[[2oo1]] – hBRD3 bromodomain 2<br />
-	**[[2e7n]] – hBRD3 bromodomain 2 - NMR<br />
-	**[[5hfr]] – hBRD3 bromodomain 2 (mutant)<br />
-	**[[5hjc]] – hBRD3 bromodomain 2+ histone H3.1 peptide<br />
-	**[[5a7c]] – hBRD3 bromodomain 2 + inhibitor<br />
-	**[[6bgh]] – hBRD3 ET domain + BRG1 peptide - NMR<br />
-	**[[6bgg]] – hBRD3 ET domain + CHD4 peptide - NMR<br />
-
-	*Bromodomain-containing protein 4
-
-	**[[2oss]], [[4j3i]], [[4lyi]], [[5hq7]], [[5hq6]], [[5hq5]] – hBRD4 bromodomain 1<br />
-	**[[2ouo]] – hBRD4 bromodomain 2<br />
-	**[[2i8n]] – hBRD4 bromodomain 2 - NMR<br />
-	**[[6bnh]] – hBRD4 ET domain + JMJD6 peptide - NMR<br />
-	**[[3jvj]] – mBRD4 bromodomain 1<br />
-	**[[2dww]], [[3jvl]], [[3jvm]] – mBRD4 bromodomain 2<br />
-	**[[2jns]] – mBRD4 ET domain - NMR<br />
-
-	*Bromodomain-containing protein 4 complex
-
-	**[[6dne]] – hBRD4 + inhibitor<br />
-
-	*Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex
-
-	**[[3jvk]], [[3muk]], [[3mul]], [[5nnd]], [[5nnc]] – mBRD4 bromodomain 1 + histone H3.3 peptide<br />
-	**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br />
-	**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br />
-	**[[6g0o]], [[6g0p]], [[6g0q]], [[6g0r]], [[6g0s]], [[5nng]], [[5nnf]], [[5nne]] – hBRD4 bromodomain 1 + peptide<br />
-	**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br />
-	**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]], [[6q3y]], [[6q3z]], [[6mau]], [[6hdq]], [[6fnx]], [[6fo5]], [[6fsy]], [[6ft3]], [[6ft4]], [[6e4a]], [[6dmj]], [[6dml]], [[6djc]], [[6czu]], [[6czv]], [[6ckr]], [[6cks]], [[6cis]], [[6ciy]], [[6cj1]], [[6cj2]], [[6cd4]], [[6cd5]], [[6afr]], [[5z1r]], [[5z1s]], [[5z1t]], [[5z5t]], [[5z5u]], [[5z5v]], [[5z8g]], [[5z8r]], [[5z90]], [[5z9k]], [[5yqx]], [[5y93]], [[5y94]], [[5y8c]], [[5y8w]], [[5y8w]], [[5y8y]], [[5y8z]], [[5xhy]], [[5xi2]], [[5xi3]], [[5xi4]], [[5wma]], [[5wa5]], [[5w55]], [[5vzs]], [[5vbp]], [[5vbo]], [[5ovb]], [[5o97]] – hBRD4 bromodomain 1 + inhibitor<br />
-	**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br />
-	**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br />
-	**[[4lys]], [[4lzr]] – hBRD4 bromodomain 1 + colchiceine<br />
-	**[[4qb3]] – hBRD4 bromodomain 1 + olinone<br />
-	**[[4whw]] – hBRD4 bromodomain 1 + probe<br />
-	**[[5igk]] – hBRD4 bromodomain 1 + bromosporine<br />
-	**[[5hcl]] – hBRD4 bromodomain 1 + drug<br />
-	**[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br />
-
-	*Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex
-
-	**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]] – hBRD4 bromodomain 2 + inhibitor<br />
-	**[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br />
-	**[[4kv4]] – hBRD4 bromodomain 2 + Rel peptide<br />
-	**[[2mjv]] – hBRD4 bromodomain 2 + Twist peptide<br />
-	**[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br />
-	**[[5t35]] – hBRD4 bromodomain 2 + ELOB + ELOC + PVHL peptide<br />
-
-	*Bromodomain-containing protein 7
-
-	**[[5mq1]] – hBRD7 bromodomain + inhibitor<br />
-
-	*Bromodomain-containing protein 9
-
-	**[[3hme]] – hBRD9 bromodomain <br />
-	**[[5ji8]] – hBRD9 JUS-SPRY domain <br />
-	**[[5ign]] – hBRD9 bromodomain + L999 <br />
-	**[[5igm]] – hBRD9 bromodomain + bromosporine <br />
-	**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]] – hBRD9 bromodomain + inhibitor<br />
-	**[[4yy4]] – hBRD9 bromodomain + DMSO<br />
-	**[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br />
-	**[[4uit]], [[4uiu]], [[4uiv]], [[4uiw]] – hBRD9 JUS-SPRY domain + inhibitor<br />
-	**[[5i7y]], [[5i7x]], [[5i40]] – hBRD9 JUS-SPRY domain + inhibitor<br />
-	**[[5twx]] – hBRD9 bromodomain residues 134-250 + heterobifunctional ligand<br />
-	}}
-
-

	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 08:12, 18 April 2019

Michal Harel — Thu, 18 Apr 2019 08:12:52 GMT

Alexander Berchansky at 11:04, 8 January 2019

Alexander Berchansky — Tue, 08 Jan 2019 11:04:54 GMT

←Older revision		Revision as of 11:04, 8 January 2019
Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	<scene name='72/724778/Cv/3'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.	+	<scene name='72/724778/Cv/4'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 11:33, 27 May 2018

Alexander Berchansky — Sun, 27 May 2018 11:33:32 GMT

←Older revision		Revision as of 11:33, 27 May 2018
Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	<scene name='72/724778/Cv/3'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>.	+	<scene name='72/724778/Cv/3'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 10:04, 3 April 2018

Michal Harel — Tue, 03 Apr 2018 10:04:44 GMT

←Older revision		Revision as of 10:04, 3 April 2018
Line 84:		Line 84:
	**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br />		**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br />
	**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br />		**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br />
-	**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli], [[5mkz]]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]] – hBRD4 bromodomain 1 + inhibitor<br />	+	**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]] – hBRD4 bromodomain 1 + inhibitor<br />
	**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br />		**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br />
	**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br />		**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br />

←Older revision		Revision as of 08:12, 18 April 2019
Line 13:		Line 13:

	<scene name='72/724778/Cv/4'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.		<scene name='72/724778/Cv/4'>BRD4 bromodomain 1 inhibitors bind to the acetyl-binding pocket</scene><ref>PMID:18552174</ref>. Water molecules are shown as red spheres.
		+
		+
		+	== 3D Structures of bromodomain-containing protein ==
		+	[[Bromodomain-containing protein 3D structures]]

	</StructureSection>		</StructureSection>
Line 27:		Line 31:
	**[[3l43]] – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR<br />		**[[3l43]] – histone H3.3 N-terminal/hBRD1 PHD1 zinc finger domain - NMR<br />
	**[[3rcw]], [[4z02]] – hBRD1 bromodomain residues 555-688<br />		**[[3rcw]], [[4z02]] – hBRD1 bromodomain residues 555-688<br />
-	**[[5pwb]], [[5pwa]], [[5pw9]], [[5pw8]], [[5pw7]], [[5pw6]], [[5pw5]], [[5pw4]], [[5pw3]], [[5pw2]], [[5pw1]], [[5pw0]], [[5pvz]], [[5pvy]], [[5pvx]], [[5pvw]], [[5pvv]], [[5pvu]], [[5pvt]], [[5pvs]], [[5pvr]], [[5pvq]], [[5pvp]], [[5pvo]], [[5pvn]], [[5pvm]], [[5pvl]], [[5pvk]], [[5pvj]], [[5pvi]], [[5pvh]], [[5pvg]], [[5pvf]], [[5pve]], [[5pvd]], [[5pvc]], [[5pvb]], [[5pva]], [[5pv9]], [[5pv8]], [[5pv7]], [[5pv6]], [[5pv5]], [[5pv4]], [[5pv3]], [[5pv2]], [[5pv1]], [[5pv0]], [[5puz]], [[5puy]], [[5pux]], [[5puw]], [[5puv]], [[5puu]], [[5put]], [[5pus]], [[5pur]], [[5puq]], [[5pup]], [[5pun]], [[5pum]], [[5puo]], [[5pul]], [[5puk]], [[5puj]], [[5pui]], [[5puh]], [[5pug]], [[5puf]], [[5pue]], [[5pud]], [[5puc]], [[5pub]], [[5pua]], [[5pu9]], [[5pu8]], [[5pu7]], [[5pu6]], [[5pu5]], [[5pu4]], [[5pu3]], [[5pu2]], [[5pu1]], [[5pu0]], [[5ptz]], [[5pty]], [[5ptx]], [[5ptw]], [[5ptv]], [[5ptu]], [[5pts]], [[5ptt]], [[5ptr]], [[5ptq]], [[5ptp]], [[5pto]], [[5ptn]], [[5ptm]], [[5ptl]], [[5ptk]], [[5ptj]], [[5pth]], [[5ptg]], [[5ptf]], [[5pte]], [[5ptd]], [[5ptc]], [[5ptb]], [[5pta]], [[5pt9]], [[5pt8]], [[5pt7]] – [[5pnx]] – hBRD1 ~~bromodomain~~ (mutant)<br />	+	**[[5pwb]], [[5pwa]], [[5pw9]], [[5pw8]], [[5pw7]], [[5pw6]], [[5pw5]], [[5pw4]], [[5pw3]], [[5pw2]], [[5pw1]], [[5pw0]], [[5pvz]], [[5pvy]], [[5pvx]], [[5pvw]], [[5pvv]], [[5pvu]], [[5pvt]], [[5pvs]], [[5pvr]], [[5pvq]], [[5pvp]], [[5pvo]], [[5pvn]], [[5pvm]], [[5pvl]], [[5pvk]], [[5pvj]], [[5pvi]], [[5pvh]], [[5pvg]], [[5pvf]], [[5pve]], [[5pvd]], [[5pvc]], [[5pvb]], [[5pva]], [[5pv9]], [[5pv8]], [[5pv7]], [[5pv6]], [[5pv5]], [[5pv4]], [[5pv3]], [[5pv2]], [[5pv1]], [[5pv0]], [[5puz]], [[5puy]], [[5pux]], [[5puw]], [[5puv]], [[5puu]], [[5put]], [[5pus]], [[5pur]], [[5puq]], [[5pup]], [[5pun]], [[5pum]], [[5puo]], [[5pul]], [[5puk]], [[5puj]], [[5pui]], [[5puh]], [[5pug]], [[5puf]], [[5pue]], [[5pud]], [[5puc]], [[5pub]], [[5pua]], [[5pu9]], [[5pu8]], [[5pu7]], [[5pu6]], [[5pu5]], [[5pu4]], [[5pu3]], [[5pu2]], [[5pu1]], [[5pu0]], [[5ptz]], [[5pty]], [[5ptx]], [[5ptw]], [[5ptv]], [[5ptu]], [[5pts]], [[5ptt]], [[5ptr]], [[5ptq]], [[5ptp]], [[5pto]], [[5ptn]], [[5ptm]], [[5ptl]], [[5ptk]], [[5ptj]], [[5pth]], [[5ptg]], [[5ptf]], [[5pte]], [[5ptd]], [[5ptc]], [[5ptb]], [[5pta]], [[5pt9]], [[5pt8]], [[5pt7]], [[5pt0]], [[5pt1]], [[5pt2]], [[5pt3]], [[5pt4]], [[5pt5]], [[5pt6]], [[5pnx]], [[5pq0]], [[5pq1]], [[5pq2]], [[5pq3]], [[5pq4]], [[5pq5]], [[5pq6]], [[5pq7]], [[5pq8]], [[5pq9]], [[5pqa]], [[5pqb]], [[5pqc]], [[5pqd]], [[5pqe]], [[5pqf]], [[5pqg]], [[5pqh]], [[5pqi]], [[5pqj]], [[5pqk]], [[5pql]], [[5pqm]], [[5pqn]], [[5pqo]], [[5pqp]], [[5pqq]], [[5pqr]], [[5pqs]], [[5pqt]], [[5pqu]], [[5pqv]], [[5pqw]], [[5pqx]], [[5pqy]], [[5pqz]], [[5pr0]], [[5pr1]], [[5pr2]], [[5pr3]], [[5pr4]], [[5pr5]], [[5pr6]], [[5pr7]], [[5pr8]], [[5pr9]], [[5pra]], [[5prb]], [[5prc]], [[5prd]], [[5pre]], [[5prf]], [[5prg]], [[5prh]], [[5pri]], [[5prj]], [[5prk]], [[5prl]], [[5prm]], [[5prn]], [[5pro]], [[5prp]], [[5prq]], [[5prr]], [[5prs]], [[5prt]], [[5pru]], [[5prv]], [[5prw]], [[5prx]], [[5pry]], [[5prz]], [[5ps0]], [[5ps1]], [[5ps2]], [[5ps3]], [[5ps4]], [[5ps5]], [[5ps6]], [[5ps7]], [[5ps8]], [[5ps9]], [[5psa]], [[5psb]], [[5psc]], [[5psd]], [[5pse]], [[5psf]], [[5psg]], [[5psh]], [[5psi]], [[5psj]], [[5psk]], [[5psl]], [[5psm]], [[5psn]], [[5pso]], [[5psp]], [[5psq]], [[5psr]], [[5pss]], [[5pst]], [[5psu]], [[5psv]], [[5psw]], [[5psx]], [[5psy]], [[5psz]] - hBRD1 residues 555-668 (mutant)<br />
	**[[5n49]] – hBRD1 bromodomain + inhibitor<br />		**[[5n49]] – hBRD1 bromodomain + inhibitor<br />
		+	**[[5pny]], [[5pnz]], [[5po0]], [[5po1]], [[5po2]], [[5po3]], [[5po4]], [[5po5]], [[5po6]], [[5po7]], [[5po8]], [[5po9]], [[5poa]], [[5pob]], [[5poc]], [[5pod]], [[5poe]], [[5pof]], [[5pog]], [[5poh]], [[5poi]], [[5poj]], [[5pok]], [[5pol]], [[5pom]], [[5pon]], [[5poo]], [[5pop]], [[5poq]], [[5por]], [[5pos]], [[5pot]], [[5pou]], [[5pov]], [[5pow]], [[5pox]], [[5poy]], [[5poz]], [[5pp0]], [[5pp1]], [[5pp2]], [[5pp3]], [[5pp4]], [[5pp5]], [[5pp6]], [[5pp7]], [[5pp8]], [[5pp9]], [[5ppa]], [[5ppb]], [[5ppc]], [[5ppd]], [[5ppe]], [[5ppf]], [[5ppg]], [[5pph]], [[5ppi]], [[5ppj]], [[5ppk]], [[5ppl]], [[5ppm]], [[5ppn]], [[5ppo]], [[5ppp]], [[5ppq]], [[5ppr]], [[5pps]], [[5ppt]], [[5ppu]], [[5ppv]], [[5ppw]], [[5ppx]], [[5ppy]], [[5ppz]] – hBRD1 bromodomain (mutant) + inhibitor<br />
	**[[5ame]] – hBRD1 bromodomain+PHD (mutant) + piperazine derivative<br />		**[[5ame]] – hBRD1 bromodomain+PHD (mutant) + piperazine derivative<br />
	**[[5amf]] – hBRD1 bromodomain+PHD (mutant) + indazole derivative<br />		**[[5amf]] – hBRD1 bromodomain+PHD (mutant) + indazole derivative<br />
Line 39:		Line 44:
	**[[5hel]], [[5hem]], [[5hen]], [[5hfq]] – hBRD2 bromodomain 1 (mutant)<br />		**[[5hel]], [[5hem]], [[5hen]], [[5hfq]] – hBRD2 bromodomain 1 (mutant)<br />
	**[[2g4a]] – hBRD2 residues 1-116 - NMR<br />		**[[2g4a]] – hBRD2 residues 1-116 - NMR<br />
		+	**[[6cui]] – hBRD2 residues 621-750 - NMR<br />
	**[[5ibn]] – hBRD2 bromodomain 2 <br />		**[[5ibn]] – hBRD2 bromodomain 2 <br />
	**[[4qeu]], [[5dfb]] – hBRD2 bromodomain 2 (mutant)<br />		**[[4qeu]], [[5dfb]] – hBRD2 bromodomain 2 (mutant)<br />
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	**[[3oni]] – hBRD2 residues 224-335 + inhibitor<br />		**[[3oni]] – hBRD2 residues 224-335 + inhibitor<br />
	**[[3aqa]], [[2ydw]], [[2yek]], [[4a9e]], [[4a9f]], [[4a9h]], [[4a9i]], [[4a9j]], [[4a9m]], [[4a9n]], [[4a9o]], [[4alh]], [[4akn]], [[4alg]], [[4uyf]], [[4uyg]], [[4uyh]] – hBRD2 N-terminal bromodomain + inhibitor<br />		**[[3aqa]], [[2ydw]], [[2yek]], [[4a9e]], [[4a9f]], [[4a9h]], [[4a9i]], [[4a9j]], [[4a9m]], [[4a9n]], [[4a9o]], [[4alh]], [[4akn]], [[4alg]], [[4uyf]], [[4uyg]], [[4uyh]] – hBRD2 N-terminal bromodomain + inhibitor<br />
-	**[[4mr5]], [[4mr6]], [[4j1p]], [[5ig6]], [[5ek9]], [[5dw1]], [[5xhk]], [[5xhe]], [[5u6v]], [[5n2l]] – hBRD2 bromodomain 2 + inhibitor<br />	+	**[[4mr5]], [[4mr6]], [[4j1p]], [[5ig6]], [[5ek9]], [[5dw1]], [[5xhk]], [[5xhe]], [[5u6v]], [[5n2l]], [[6mo7]], [[6mo8]], [[6mo9]], [[6moa]] – hBRD2 bromodomain 2 + inhibitor<br />
	**[[5o3i]], [[5o3h]], [[5o3g]], [[5o3f]], [[5o3e]], [[5o3d]], [[5o3c]], [[5o3b]], [[5o3a]], [[5o39]], [[5o38]] – hBRD2 bromodomain 2 (mutant) + inhibitor<br />		**[[5o3i]], [[5o3h]], [[5o3g]], [[5o3f]], [[5o3e]], [[5o3d]], [[5o3c]], [[5o3b]], [[5o3a]], [[5o39]], [[5o38]] – hBRD2 bromodomain 2 (mutant) + inhibitor<br />
	**[[5u5s]] – hBRD2 bromodomain 2 + STAT3 peptide - NMR<br />		**[[5u5s]] – hBRD2 bromodomain 2 + STAT3 peptide - NMR<br />
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	**[[2jns]] – mBRD4 ET domain - NMR<br />		**[[2jns]] – mBRD4 ET domain - NMR<br />

-	*Bromodomain-containing protein 4 bromodomain 1 complex	+	*Bromodomain-containing protein 4 complex
		+
		+	**[[6dne]] – hBRD4 + inhibitor<br />
		+
		+	*Bromodomain-containing protein 4 bromodomain 1 residues 44-168 complex

-	**[[3jvk]], [[3muk]], [[3mul]] – mBRD4 bromodomain 1 + histone H3.3 peptide<br />	+	**[[3jvk]], [[3muk]], [[3mul]], [[5nnd]], [[5nnc]] – mBRD4 bromodomain 1 + histone H3.3 peptide<br />
	**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br />		**[[3uvw]], [[3uvy]], [[3uvx]], [[3uw9]] – hBRD4 bromodomain 1 + histone H4 peptide<br />
	**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br />		**[[4kv1]] – hBRD4 bromodomain 1 + Rel peptide<br />
		+	**[[6g0o]], [[6g0p]], [[6g0q]], [[6g0r]], [[6g0s]], [[5nng]], [[5nnf]], [[5nne]] – hBRD4 bromodomain 1 + peptide<br />
	**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br />		**[[3mxf]] – mBRD4 bromodomain 1 + inhibitor<br />
-	**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]] – hBRD4 bromodomain 1 + inhibitor<br />	+	**[[3p5o]], [[2yel]], [[3zyu]], [[3u5j]], [[3u5k]], [[3u5l]], [[4a9l]], [[4e96]], [[4f3i]], [[4hxk]], [[4hxl]], [[4hxm]], [[4hxn]], [[4hxo]], [[4hxp]], [[4hxr]], [[4hxs]], [[4lr6]], [[4lrg]], [[3svf]], [[3svg]], [[4gpj]], [[4hbv]], [[4hbw]], [[4hbx]], [[4hby]], [[4don]], [[4j0r]], [[4j0s]], [[4bw1]], [[4bw2]], [[4bw3]], [[4bw4]], [[4men]], [[4meo]], [[4mep]], [[4meq]], [[4bjx]], [[4c66]], [[4c67]], [[4ioo]], [[4ioq]], [[4ior]], [[4mr3]], [[4mr4]], [[4nqm]], [[4nr8]], [[4cfk]], [[4cfl]], [[4lyw]], [[4ogi]], [[4ogj]], [[4o70]], [[4o71]], [[4o72]], [[4o74]], [[4o75]], [[4o76]], [[4o77]], [[4o78]], [[4o7a]], [[4o7b]], [[4o7c]], [[4o7e]], [[4o7f]], [[4ps5]], [[4nuc]], [[4nue]], [[4nud]], [[4pce]], [[4pci]], [[4uyd]], [[4qzs]], [[4wiv]], [[4cl9]], [[4clb]], [[4xy9]], [[4xya]], [[4z1q]], [[4z1s]], [[4uix]], [[4uiy]], [[4uiz]], [[4qr3]], [[4qr4]], [[4qr5]], [[5bt4]], [[5a5s]], [[5a85]], [[5acy]], [[4x2i]], [[4zc9]], [[5fbx]], [[4yh3]], [[4yh4]], [[5coi]], [[5cp5]], [[5cpe]], [[5cqt]], [[5crm]], [[5crz]], [[5cs8]], [[5ctl]], [[5cy9]], [[5d0c]], [[5dx4]], [[4lzs]], [[5d24]], [[5d25]], [[5d26]], [[5d3h]], [[5d3j]], [[5d3l]], [[5d3n]], [[5d3p]], [[5d3r]], [[5d3s]], [[5d3t]], [[5egu]], [[5ei4]], [[5eis]], [[5hls]], [[5hm0]], [[5ku3]], [[5khm]], [[5i88]], [[5i80]], [[5f63]], [[5f62]], [[5f61]], [[5f60]], [[5e0r]], [[5dw2]], [[5dlz]], [[5dlx]], [[5cfw]], [[5ad3]], [[5ad2]], [[4zw1]], [[5u2f]], [[5u2e]], [[5u28]], [[5luu]], [[5lj2]], [[5lj1]], [[5y1y]], [[5wuu]], [[5vom]], [[5v67]], [[5uvw]], [[5ula]], [[5ti7]], [[5n2m]], [[5mli]], [[5mkz]], [[5m3a]], [[5m39]], [[5lrq]], [[5kj0]], [[5kdh]], [[5h21]], [[5f5z]], [[6q3y]], [[6q3z]], [[6mau]], [[6hdq]], [[6fnx]], [[6fo5]], [[6fsy]], [[6ft3]], [[6ft4]], [[6e4a]], [[6dmj]], [[6dml]], [[6djc]], [[6czu]], [[6czv]], [[6ckr]], [[6cks]], [[6cis]], [[6ciy]], [[6cj1]], [[6cj2]], [[6cd4]], [[6cd5]], [[6afr]], [[5z1r]], [[5z1s]], [[5z1t]], [[5z5t]], [[5z5u]], [[5z5v]], [[5z8g]], [[5z8r]], [[5z90]], [[5z9k]], [[5yqx]], [[5y93]], [[5y94]], [[5y8c]], [[5y8w]], [[5y8w]], [[5y8y]], [[5y8z]], [[5xhy]], [[5xi2]], [[5xi3]], [[5xi4]], [[5wma]], [[5wa5]], [[5w55]], [[5vzs]], [[5vbp]], [[5vbo]], [[5ovb]], [[5o97]] – hBRD4 bromodomain 1 + inhibitor<br />
	**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br />		**[[5z9c]] – hBRD4 bromodomain 1 + inhibitor - NMR<br />
-	**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br />	+	**[[5ti6]], [[5ti5]], [[5ti4]], [[5ti3]], [[5ti2]], [[5you]], [[5yov]], [[5wmd]], [[5wmg]] – hBRD4 bromodomain 1 (mutant) + inhibitor <br />
	**[[4lys]], [[4lzr]] – hBRD4 bromodomain 1 + colchiceine<br />		**[[4lys]], [[4lzr]] – hBRD4 bromodomain 1 + colchiceine<br />
	**[[4qb3]] – hBRD4 bromodomain 1 + olinone<br />		**[[4qb3]] – hBRD4 bromodomain 1 + olinone<br />
Line 92:		Line 103:
	**[[5igk]] – hBRD4 bromodomain 1 + bromosporine<br />		**[[5igk]] – hBRD4 bromodomain 1 + bromosporine<br />
	**[[5hcl]] – hBRD4 bromodomain 1 + drug<br />		**[[5hcl]] – hBRD4 bromodomain 1 + drug<br />
		+	**[[6bn7]], [[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hBRD4 bromodomain 1 (mutant) + DNA damage-binding protein + cereblon<br />

-	*Bromodomain-containing protein 4 bromodomain 2 complex	+	*Bromodomain-containing protein 4 bromodomain 2 residues 344-455 complex

-	**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]] – hBRD4 bromodomain 2 + inhibitor<br />	+	**[[2yem]], [[4z93]], [[5u2c]], [[5jwm]], [[5uvz]], [[5uvy]], [[5uvx]], [[5uvv]], [[5uvu]], [[5uvt]], [[5uvs]], [[5uoo]], [[5uf0]], [[5uez]], [[5uey]], [[5uex]], [[5uew]], [[5uev]], [[5ueu]], [[5uet]], [[5ues]], [[5uer]], [[5ueq]], [[5uep]], [[5ueo]], [[6ffd]], [[6ffe]], [[6ffg]], [[6c7q]], [[6c7r]] – hBRD4 bromodomain 2 + inhibitor<br />
	**[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br />		**[[2lsp]] – hBRD4 bromodomain 2 + Nf-Kb peptide<br />
	**[[4kv4]] – hBRD4 bromodomain 2 + Rel peptide<br />		**[[4kv4]] – hBRD4 bromodomain 2 + Rel peptide<br />
	**[[2mjv]] – hBRD4 bromodomain 2 + Twist peptide<br />		**[[2mjv]] – hBRD4 bromodomain 2 + Twist peptide<br />
		+	**[[6mnl]] – hBRD4 bromodomain 2 + foxo3a peptide<br />
	**[[5t35]] – hBRD4 bromodomain 2 + ELOB + ELOC + PVHL peptide<br />		**[[5t35]] – hBRD4 bromodomain 2 + ELOB + ELOC + PVHL peptide<br />

Line 111:		Line 124:
	**[[5ign]] – hBRD9 bromodomain + L999 <br />		**[[5ign]] – hBRD9 bromodomain + L999 <br />
	**[[5igm]] – hBRD9 bromodomain + bromosporine <br />		**[[5igm]] – hBRD9 bromodomain + bromosporine <br />
-	**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]] – hBRD9 bromodomain + inhibitor<br />	+	**[[4nqn]], [[4xy8]], [[4z6h]], [[4z6i]], [[5e9v]], [[5f2p]], [[5f25]], [[5f1l]], [[5f1h]], [[5eu1]], [[5mky]], [[6hm0]], [[6bqa]] – hBRD9 bromodomain + inhibitor<br />
	**[[4yy4]] – hBRD9 bromodomain + DMSO<br />		**[[4yy4]] – hBRD9 bromodomain + DMSO<br />
	**[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br />		**[[4yy6]], [[4yyd]], [[4yyg]], [[4yyh]], [[4yyj]], [[4yyk]], [[4yyi]] – hBRD9 bromodomain + histone H4 peptide<br />