Choline O-acetyltransferase - Revision history

Michal Harel at 06:25, 7 June 2021

Michal Harel — Mon, 07 Jun 2021 06:25:14 GMT

←Older revision		Revision as of 06:25, 7 June 2021
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[1q6x]], [[1t1u]] – ChaT – rat

	[[2fy2]] – hChaT – human		[[2fy2]] – hChaT – human
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	[[2fy4]] – hChaT + CoA		[[2fy4]] – hChaT + CoA

-	[[2fy5]] – hChaT + CoA derivative	+	[[2fy5]] – hChaT + CoA derivative<br />
		+	[[7amd]] - hChaT + pyridine derivative<br />
		+	[[1q6x]], [[1t1u]] – ChaT – rat
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 11:10, 16 December 2018

Alexander Berchansky — Sun, 16 Dec 2018 11:10:30 GMT

←Older revision		Revision as of 11:10, 16 December 2018
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	== Structural highlights ==		== Structural highlights ==

-	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The <scene name='46/467280/Cv/4'>active site is a tunnel in which acetyl-CoA is bound at the surface</scene> and the <scene name='46/467280/Cv/5'>choline at the interior pocket</scene>.<ref>PMID:17144655</ref>	+	Human ChaT contains 2 domains: <scene name='46/467280/Cv/6'>substrate-binding and catalytic domain</scene>. The <scene name='46/467280/Cv/7'>active site is a tunnel in which acetyl-CoA is bound at the surface</scene> and the <scene name='46/467280/Cv/8'>choline at the interior pocket</scene>.<ref>PMID:17144655</ref>

	</StructureSection>		</StructureSection>

Michal Harel at 10:34, 22 November 2018

Michal Harel — Thu, 22 Nov 2018 10:34:38 GMT

←Older revision		Revision as of 10:34, 22 November 2018
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	== Function ==		== Function ==

-	'''Choline O-acetyltransferase''' (~~ChaT~~) catalyzes the synthesis of acetyl-CoA ~~and choline to form the neurotransmitter acetylcholine. ChaT is found~~ in ~~nerve terminals~~.<ref>PMID:~~10594838~~</ref>	+	'''Choline acetyltransferase''' (ChAT) catalyzes the synthesis of acetylcholine (ACh) from the precursors choline and acetyl-CoA in cholinergic neurons. The post-translational phosphorylation of ChAT at Ser440 and Thr456 regulate its activity, binding to plasma membrane and interaction with other proteins<ref>PMID:12675142</ref>.

	== Disease ==		== Disease ==

-	Mutations in human ChaT are linked to congenital ~~mysthenic~~ syndrome. The concentration of ChaT is reduced in brains of Alzheimer's Disease and ALS patients.	+	Abnormalities of ChAT in the brain have been demonstrated in schizophrenia and sudden infant death syndrome<ref>PMID:10594838</ref>. Mutations in human ChaT are linked to congenital myasthenic syndrome<ref>PMID:12548525</ref>.
		+
		+	== Relevance ==
		+
		+	Greater activity and higher ChAT levels in the hippocampus are associated with better performance on hippocampus-based learning and memory tasks<ref>PMID:25930215</ref>. The concentration of ChaT is reduced in brains of Alzheimer's Disease and ALS patients<ref>PMID:23840379</ref>.

	== Structural highlights ==		== Structural highlights ==

Alexander Berchansky at 13:42, 14 December 2015

Alexander Berchansky — Mon, 14 Dec 2015 13:42:53 GMT

←Older revision		Revision as of 13:42, 14 December 2015
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	== Structural highlights ==		== Structural highlights ==

-	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The <scene name='46/467280/Cv/4'>active site is a tunnel in which acetyl-CoA is bound at the surface</scene> and the choline at the interior pocket.<ref>PMID:17144655</ref>	+	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The <scene name='46/467280/Cv/4'>active site is a tunnel in which acetyl-CoA is bound at the surface</scene> and the <scene name='46/467280/Cv/5'>choline at the interior pocket</scene>.<ref>PMID:17144655</ref>

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:29, 14 December 2015

Alexander Berchansky — Mon, 14 Dec 2015 13:29:01 GMT

←Older revision		Revision as of 13:29, 14 December 2015
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	== Structural highlights ==		== Structural highlights ==

-	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The active site is a tunnel in which acetyl-CoA is bound at the surface and the choline at the interior pocket.<ref>PMID:17144655</ref>	+	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The <scene name='46/467280/Cv/4'>active site is a tunnel in which acetyl-CoA is bound at the surface</scene> and the choline at the interior pocket.<ref>PMID:17144655</ref>

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:14, 14 December 2015

Alexander Berchansky — Mon, 14 Dec 2015 13:14:42 GMT

←Older revision		Revision as of 13:14, 14 December 2015
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	== Structural highlights ==		== Structural highlights ==

-	Human ChaT contains 2 domains: substrate-binding and catalytic domain. The active site is a tunnel in which acetyl-CoA is bound at the surface and the choline at the interior pocket.<ref>PMID:17144655</ref>	+	Human ChaT contains 2 domains: <scene name='46/467280/Cv/2'>substrate-binding and catalytic domain</scene>. The active site is a tunnel in which acetyl-CoA is bound at the surface and the choline at the interior pocket.<ref>PMID:17144655</ref>

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:09, 14 December 2015

Alexander Berchansky — Mon, 14 Dec 2015 13:09:31 GMT

←Older revision		Revision as of 13:09, 14 December 2015
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-	<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>	+	<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene='46/467280/Cv/1'>
	__TOC__		__TOC__
	== Function ==		== Function ==

Michal Harel at 07:58, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 07:58:11 GMT

←Older revision		Revision as of 07:58, 8 December 2015
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-
	<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>		<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>
	__TOC__		__TOC__
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	== Structural highlights ==		== Structural highlights ==
		+
		+	Human ChaT contains 2 domains: substrate-binding and catalytic domain. The active site is a tunnel in which acetyl-CoA is bound at the surface and the choline at the interior pocket.<ref>PMID:17144655</ref>

	</StructureSection>		</StructureSection>

Michal Harel at 07:39, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 07:39:32 GMT

←Older revision		Revision as of 07:39, 8 December 2015
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-

	<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>		<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>
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	== Function ==		== Function ==

-	'''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals.	+	'''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals.<ref>PMID:10594838</ref>
		+
		+	== Disease ==
		+
		+	Mutations in human ChaT are linked to congenital mysthenic syndrome. The concentration of ChaT is reduced in brains of Alzheimer's Disease and ALS patients.
		+
		+	== Structural highlights ==
		+
	</StructureSection>		</StructureSection>

Michal Harel at 07:33, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 07:33:11 GMT

←Older revision		Revision as of 07:33, 8 December 2015
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-	{{STRUCTURE_2fy3\| PDB=2fy3 \| SIZE=350\| SCENE= \|right\|CAPTION=Human choline O-acetyltransferase complex with choline, [[2fy3]] }}

-	'''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals.

-	~~{{TOC limit\|limit~~=~~2}}~~	+	<StructureSection load='2fy3' size='350' side='right' caption='Human choline O-acetyltransferase complex with choline (PDB entry [[2fy3]])' scene=''>
		+	__TOC__
		+	== Function ==
		+
		+	'''Choline O-acetyltransferase''' (ChaT) catalyzes the synthesis of acetyl-CoA and choline to form the neurotransmitter acetylcholine. ChaT is found in nerve terminals.
		+	</StructureSection>

	== 3D Structures of choline O-acetyltransferase ==		== 3D Structures of choline O-acetyltransferase ==
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	[[2fy5]] – hChaT + CoA derivative		[[2fy5]] – hChaT + CoA derivative
-		+	== References ==
		+	<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]