Cholinesterase - Revision history

Alexander Berchansky: Undo revision 3110688 by Alexander Berchansky (Talk)

Alexander Berchansky — Mon, 18 Nov 2019 15:44:30 GMT

Undo revision 3110688 by Alexander Berchansky (Talk)

←Older revision		Revision as of 15:44, 18 November 2019
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-	<Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' >	+	<Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' />

Alexander Berchansky at 15:44, 18 November 2019

Alexander Berchansky — Mon, 18 Nov 2019 15:44:17 GMT

←Older revision		Revision as of 15:44, 18 November 2019
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-	<Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' />	+	<Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' >

Joel L. Sussman at 13:22, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:22:32 GMT

←Older revision		Revision as of 13:22, 6 February 2019
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	They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE).		They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE).
-	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of ~~<scene name='Cholinesterase/Human_acetylcholinesterase/1'>~~AChE~~</scene>~~ occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.	+	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.

Joel L. Sussman at 13:21, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:21:38 GMT

←Older revision		Revision as of 13:21, 6 February 2019
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-	<Structure load='~~1b41~~' size='350' frame='true' align='right' caption='~~Insert caption here~~' scene='~~Insert optional scene name here~~' />	+	<Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' />

Joel L. Sussman at 13:18, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:18:32 GMT

←Older revision		Revision as of 13:18, 6 February 2019
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	They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE).		They are mainly of two types, namely [[acetylcholinesterase]] (AChE) and [[butyrylcholinesterase]] (BChE).
-	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.	+	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of <scene name='Cholinesterase/Human_acetylcholinesterase/1'>AChE</scene> occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.

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-
-	<scene name='Cholinesterase/Human_acetylcholinesterase/1'>

	Pseudocholinesterase (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.		Pseudocholinesterase (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.

Joel L. Sussman at 13:16, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:16:40 GMT

←Older revision		Revision as of 13:16, 6 February 2019
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-	<Structure load='1b41' size='350' frame='true' align='right' caption='~~Glycosylated Human acetylcholinesterase complex with fasciculin-II, [[1b41]]~~'>	+	<Structure load='1b41' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
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		+
	[[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.		[[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.

Joel L. Sussman at 13:15, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:15:45 GMT

←Older revision		Revision as of 13:15, 6 February 2019
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	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.		AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.

-	~~<Structure load='1b41' size='400' frame='true' align='right' caption='Glycosylated Human acetylcholinesterase complex with fasciculin-II, [[1b41]]'/>~~	+

	<scene name='Cholinesterase/Human_acetylcholinesterase/1'>		<scene name='Cholinesterase/Human_acetylcholinesterase/1'>

Joel L. Sussman at 13:15, 6 February 2019

Joel L. Sussman — Wed, 06 Feb 2019 13:15:07 GMT

←Older revision		Revision as of 13:15, 6 February 2019
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-	<~~!--~~	+	<Structure load='1b41' size='350' frame='true' align='right' caption='Glycosylated Human acetylcholinesterase complex with fasciculin-II, [[1b41]]'>
-	~~Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.~~	+
-	~~Or use the four-green-boxes-button to insert scrollable text adjacent~~	+
-	~~to a Jmol applet. Check out the other buttons as well!~~	+
-	-->	+

	[[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.		[[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.
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	The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.		The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
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		+	</StructureSection>

Michal Harel at 09:03, 1 February 2016

Michal Harel — Mon, 01 Feb 2016 09:03:16 GMT

←Older revision		Revision as of 09:03, 1 February 2016
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	The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.		The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
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-	INFORMATION PROVIDED HERE ARE NOT EXHAUSTIVE; REMAINS TO BE UPDATED

Michal Harel at 09:36, 31 July 2012

Michal Harel — Tue, 31 Jul 2012 09:36:21 GMT

←Older revision		Revision as of 09:36, 31 July 2012
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	AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.		AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.

-	<Structure load='1b41' size='400' frame='true' align='right' caption='~~human~~ acetylcholinesterase complex with fasciculin-II, [[1b41]]'/>	+	<Structure load='1b41' size='400' frame='true' align='right' caption='Glycosylated Human acetylcholinesterase complex with fasciculin-II, [[1b41]]'/>

	<scene name='Cholinesterase/Human_acetylcholinesterase/1'>		<scene name='Cholinesterase/Human_acetylcholinesterase/1'>