Circadian clock protein - Revision history

Michal Harel at 08:26, 24 November 2022

Michal Harel — Thu, 24 Nov 2022 08:26:19 GMT

←Older revision		Revision as of 08:26, 24 November 2022
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	<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>

-	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].	+	'''Circadian clock proteins''' or '''Circadian clock protein kinase''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].

	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).		Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).

Michal Harel at 09:03, 13 May 2019

Michal Harel — Mon, 13 May 2019 09:03:26 GMT

←Older revision		Revision as of 09:03, 13 May 2019
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	</StructureSection>		</StructureSection>
-	== 3D Structures of circadian clock protein ==

-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*KaiA
-
-	**[[1r5q]] – NoKaiA - Nostoc<br />
-	**[[1m2e]], [[1m2f]] – SeKaiA N terminal – ''Synechococcus elongatus'' - NMR <br />
-	**[[1q6a]], [[1q6b]] – SeKaiA C terminal - NMR <br />
-	**[[1v2z]] – SeKaiA C terminal <br />
-	**[[1r8j]] – SeKaiA <br />
-	**[[4g86]] – SeKaiA + DBMIB<br />
-
-	*KaiB
-
-	**[[1r5p]] – NoKaiB <br />
-	**[[1wwj]] – SyKaiB - ''Synechocystis''<br />
-	**[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br />
-	**[[5jyt]] – SeKaiB (mutant) - NMR <br />
-	**[[5jyv]] – SeKaiB (mutant) + CIKA - NMR <br />
-
-	*KaiC
-
-	**[[1tf7]], [[2gbl]] – SyKaiC <br />
-	**[[1u9i]], [[3dvl]], [[3jzm]], [[3s1a]], [[4dug]], [[4ijm]], [[4o0m]] – SeKaiC (mutant) <br />
-	**[[4tl8]], [[4tl7]], [[4tl6]], [[5yz8]] – SeKaiC N terminal C1 domain<br />
-	**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]] – SeKaiC N terminal C1 domain (mutant)<br />
-
-	*KaiA+KaiC
-
-	**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
-	**[[5c5e]] – SeKaiA + KaiC peptide <br />
-
-	*KaiB+KaiC
-
-	**[[5jwo]], [[5jwq]] – SeKaiB (mutant) + KaiC (mutant) <br />
-
-	*KaiA+KaiB+KaiC
-
-	**[[5n8y]] – SeKaiA + SeKaiB + KaiC – Cryo EM <br />
-	**[[5jwr]] – SeKaiA (mutant) + SeKaiB (mutant) + KaiC (mutant) <br />
-
-
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:02, 13 May 2019

Michal Harel — Mon, 13 May 2019 09:02:18 GMT

←Older revision		Revision as of 09:02, 13 May 2019
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	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).		Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).
		+
		+	== 3D Structures of circadian clock protein ==
		+	[[Circadian clock protein 3D structures]]
		+
	</StructureSection>		</StructureSection>
	== 3D Structures of circadian clock protein ==		== 3D Structures of circadian clock protein ==
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	**[[1tf7]], [[2gbl]] – SyKaiC <br />		**[[1tf7]], [[2gbl]] – SyKaiC <br />
-	**[[1u9i]], [[3dvl]], [[3jzm~~]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f~~]], [[3s1a]], [[4dug]], [[4ijm]], [[4o0m]] – SeKaiC (mutant) <br />	+	**[[1u9i]], [[3dvl]], [[3jzm]], [[3s1a]], [[4dug]], [[4ijm]], [[4o0m]] – SeKaiC (mutant) <br />
-	**[[~~4tl6~~]] ~~– SeKaiC N terminal <br />~~	+	**[[4tl8]], [[4tl7]], [[4tl6]], [[5yz8]] – SeKaiC N terminal C1 domain<br />
-	**[[~~4tl8~~]], [[~~4tl7~~]] – SeKaiC N terminal C1 domain<br />	+	**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]] – SeKaiC N terminal C1 domain (mutant)<br />
-	**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br />	+

	*KaiA+KaiC		*KaiA+KaiC

Michal Harel at 08:36, 11 April 2018

Michal Harel — Wed, 11 Apr 2018 08:36:53 GMT

←Older revision		Revision as of 08:36, 11 April 2018
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	<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>		<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>

-	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].	+	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then '''KaiC''' binds to '''KaiB'''<ref>PMID:15716247</ref> which inactivates '''KaiA''' and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].

	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).		Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).
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	**[[1v2z]] – SeKaiA C terminal <br />		**[[1v2z]] – SeKaiA C terminal <br />
	**[[1r8j]] – SeKaiA <br />		**[[1r8j]] – SeKaiA <br />
-	**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
-	**[[5c5e]] – SeKaiA + KaiC peptide <br />
	**[[4g86]] – SeKaiA + DBMIB<br />		**[[4g86]] – SeKaiA + DBMIB<br />

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	**[[1wwj]] – SyKaiB - ''Synechocystis''<br />		**[[1wwj]] – SyKaiB - ''Synechocystis''<br />
	**[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br />		**[[1vgl]], [[2qke]], [[4kso]] – SeKaiB <br />
		+	**[[5jyt]] – SeKaiB (mutant) - NMR <br />
		+	**[[5jyv]] – SeKaiB (mutant) + CIKA - NMR <br />

	*KaiC		*KaiC
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	**[[4tl8]], [[4tl7]] – SeKaiC N terminal C1 domain<br />		**[[4tl8]], [[4tl7]] – SeKaiC N terminal C1 domain<br />
	**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br />		**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br />
		+
		+	*KaiA+KaiC
		+
		+	**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
		+	**[[5c5e]] – SeKaiA + KaiC peptide <br />
		+
		+	*KaiB+KaiC
		+
		+	**[[5jwo]], [[5jwq]] – SeKaiB (mutant) + KaiC (mutant) <br />
		+
		+	*KaiA+KaiB+KaiC
		+
		+	**[[5n8y]] – SeKaiA + SeKaiB + KaiC – Cryo EM <br />
		+	**[[5jwr]] – SeKaiA (mutant) + SeKaiB (mutant) + KaiC (mutant) <br />
		+

	}}		}}

Joel L. Sussman at 20:30, 26 November 2017

Joel L. Sussman — Sun, 26 Nov 2017 20:30:52 GMT

←Older revision		Revision as of 20:30, 26 November 2017
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-	<StructureSection load='~~1r8j~~' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>	+	<StructureSection load='' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>

	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].		'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].

Michal Harel at 08:55, 3 April 2017

Michal Harel — Mon, 03 Apr 2017 08:55:43 GMT

←Older revision		Revision as of 08:55, 3 April 2017
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	**[[1r8j]] – SeKaiA <br />		**[[1r8j]] – SeKaiA <br />
	**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />		**[[1suy]], [[1sv1]] – SeKaiA C terminal + KaiC peptide - NMR <br />
		+	**[[5c5e]] – SeKaiA + KaiC peptide <br />
	**[[4g86]] – SeKaiA + DBMIB<br />		**[[4g86]] – SeKaiA + DBMIB<br />

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	**[[1tf7]], [[2gbl]] – SyKaiC <br />		**[[1tf7]], [[2gbl]] – SyKaiC <br />
-	**[[1u9i]], [[3dvl]], [[3jzm]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]], [[3s1a]], [[4dug]], [[4ijm]] – SeKaiC (mutant) <br />	+	**[[1u9i]], [[3dvl]], [[3jzm]], [[3k09]], [[3k0a]], [[3k0c]], [[3k0e]], [[3k0f]], [[3s1a]], [[4dug]], [[4ijm]], [[4o0m]] – SeKaiC (mutant) <br />
		+	**[[4tl6]] – SeKaiC N terminal <br />
		+	**[[4tl8]], [[4tl7]] – SeKaiC N terminal C1 domain<br />
		+	**[[4tl9]], [[4tla]], [[4tlb]], [[4tlc]], [[4tld]], [[4tle]] – SeKaiC N terminal C1 domain (mutant)<br />
		+
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Alexander Berchansky at 13:59, 27 January 2016

Alexander Berchansky — Wed, 27 Jan 2016 13:59:49 GMT

←Older revision		Revision as of 13:59, 27 January 2016
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	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].		'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].

-	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).~~<ref>PMID:15007067</ref>~~	+	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).
	</StructureSection>		</StructureSection>
	== 3D Structures of circadian clock protein ==		== 3D Structures of circadian clock protein ==

Alexander Berchansky at 13:59, 27 January 2016

Alexander Berchansky — Wed, 27 Jan 2016 13:59:14 GMT

←Older revision		Revision as of 13:59, 27 January 2016
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	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].		'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].

-	Circadian clock protein KaiA from [[Synechococcus elongatus]] is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).<ref>PMID:15007067</ref>	+	Circadian clock protein KaiA from ''Synechococcus elongatus'' is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).<ref>PMID:15007067</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of circadian clock protein ==		== 3D Structures of circadian clock protein ==

Alexander Berchansky at 13:58, 27 January 2016

Alexander Berchansky — Wed, 27 Jan 2016 13:58:51 GMT

←Older revision		Revision as of 13:58, 27 January 2016
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-	<StructureSection load='1r8j' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene=''>	+	<StructureSection load='1r8j' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene='53/536683/Cv/1'>

	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].		'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].
		+
		+	Circadian clock protein KaiA from [[Synechococcus elongatus]] is <scene name='53/536683/Cv/2'>homodimer</scene> (PDB entry [[1r8j]]).<ref>PMID:15007067</ref>
	</StructureSection>		</StructureSection>
	== 3D Structures of circadian clock protein ==		== 3D Structures of circadian clock protein ==

Michal Harel at 10:59, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 10:59:50 GMT

←Older revision		Revision as of 10:59, 8 December 2015
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-
	<StructureSection load='1r8j' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene=''>		<StructureSection load='1r8j' size='350' side='right' caption='Circadian clock protein KaiA (PDB entry [[1r8j]])' scene=''>

-	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA stimulates KaiC which adds phosphate groups to itself. Then KaiC binds to KaiB which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].	+	'''Circadian clock proteins''' measure out the 24 hour circadian rhythm. In cyanobacteria protein KaiA<ref>PMID:15007067</ref> stimulates KaiC<ref>PMID:15304218</ref> which adds phosphate groups to itself. Then KaiC binds to KaiB<ref>PMID:15716247</ref> which inactivates KaiA and causes the number of phosphate groups on KaiC to drop slowly. KaiB disconnects allowing KaiA to start the cycle again.<ref>PMID:11687489</ref> For details of KaiC see [[Circadian Clock Protein KaiC]].
	</StructureSection>		</StructureSection>
	== 3D Structures of circadian clock protein ==		== 3D Structures of circadian clock protein ==