Coatomer - Revision history

Alexander Berchansky at 08:41, 8 April 2024

Alexander Berchansky — Mon, 08 Apr 2024 08:41:46 GMT

←Older revision		Revision as of 08:41, 8 April 2024
Line 4:		Line 4:
	== Function ==		== Function ==

-	COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.	+	COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.

	== Disease ==		== Disease ==
Line 12:		Line 12:
	== Structural highlights ==		== Structural highlights ==

-	The COPI/Arf-1 complex consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.	+	The <scene name='10/1041515/Cv/3'>COPI/Arf-1 complex</scene> consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.

	==Coatomer 3D structures==		==Coatomer 3D structures==

Alexander Berchansky at 08:19, 8 April 2024

Alexander Berchansky — Mon, 08 Apr 2024 08:19:25 GMT

←Older revision		Revision as of 08:19, 8 April 2024
Line 1:		Line 1:
-	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene='10/1041515/Cv/1'>	+	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene='10/1041515/Cv/2'>
	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.		'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

Alexander Berchansky at 08:16, 8 April 2024

Alexander Berchansky — Mon, 08 Apr 2024 08:16:45 GMT

←Older revision		Revision as of 08:16, 8 April 2024
Line 1:		Line 1:
-	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>	+	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene='10/1041515/Cv/1'>
	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.		'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

Michal Harel at 07:48, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:48:35 GMT

←Older revision		Revision as of 07:48, 8 April 2024
Line 8:		Line 8:
	== Disease ==		== Disease ==

-	Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:~~3584149~~</ref>.	+	Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:30804679</ref>.

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 07:45, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:45:30 GMT

←Older revision		Revision as of 07:45, 8 April 2024
Line 1:		Line 1:
	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>		<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>
-	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:~~898986~~</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.	+	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:1898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

	== Function ==		== Function ==

Michal Harel at 07:44, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:44:39 GMT

←Older revision		Revision as of 07:44, 8 April 2024
Line 9:		Line 9:

	Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.		Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.
-
-	== Relevance ==

	== Structural highlights ==		== Structural highlights ==

Michal Harel at 07:44, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:44:04 GMT

←Older revision		Revision as of 07:44, 8 April 2024
Line 14:		Line 14:
	== Structural highlights ==		== Structural highlights ==

-	~~This is a sample scene created with SAT to <scene name="/12/3456/Sample~~/1~~">color</scene> by Group~~, and ~~another to make~~ <~~scene name="/12/3456/Sample/2"~~>~~a transparent representation~~</~~scene~~> ~~of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes~~.	+	The COPI/Arf-1 complex consists of subunit alpha, subunit beta, subunit beta', subunit gamma-1, subunit delta, subunit zeta-1 and protein Arf-1<ref>PMID:28621666</ref>.

	==Coatomer 3D structures==		==Coatomer 3D structures==

Michal Harel at 07:38, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:38:33 GMT

←Older revision		Revision as of 07:38, 8 April 2024
Line 1:		Line 1:
-	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein ~~Art~~-1 (cyan) (PDB entry [[5nzu]])' scene=>	+	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Arf-1 (cyan) (PDB entry [[5nzu]])' scene=>
-	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.	+	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. Protein ADP-ribosylation factor 1 (Arf-1) is part of the vesicle-coating complex<ref>PMID:9681627</ref>.

	== Function ==		== Function ==

Michal Harel at 07:32, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:32:52 GMT

←Older revision		Revision as of 07:32, 8 April 2024
Line 1:		Line 1:
	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Art-1 (cyan) (PDB entry [[5nzu]])' scene=>		<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Art-1 (cyan) (PDB entry [[5nzu]])' scene=>
-	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. ~~COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>.~~	+	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1.
		+
	== Function ==		== Function ==

-	COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>.	+	COPI function in the sorting and trafficking of proteins between sub cellular organelles <ref>PMID:34450031</ref>. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>. Dilysine motifs on transmembrane proteins are recognised by COPI alpha and beta' subunits and packaged into COPI-coated vesicles for transport from Golgi to ER<ref>PMID:23481256</ref>.

	== Disease ==		== Disease ==

-	Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.	+	Mutations in COPI can result in osteoporosis, fractures and developmental delays. Deficiency in COPI alpha subunit cause COPA syndrome<ref>PMID:3584149</ref>.

	== Relevance ==		== Relevance ==

Michal Harel at 07:21, 8 April 2024

Michal Harel — Mon, 08 Apr 2024 07:21:01 GMT

←Older revision		Revision as of 07:21, 8 April 2024
Line 1:		Line 1:
-	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta' (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Art-1 (cyan) (PDB entry [[5nzu]])' scene=>	+	<StructureSection load='5nzu' size='350' side='right' caption='Mouse COPI coat complex containing subunits alpha (grey), beta (green), beta prime (pink), delta (yellow), gamma-1 (red), zeta-1 (aqua) and protein Art-1 (cyan) (PDB entry [[5nzu]])' scene=>
	'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>.		'''Coatomers''' (COPI) are a set of vesicles' coating proteins <ref>PMID:898986</ref>. Coatomers contain several subunits which are named according to decreasing molecular weight as alpha, beta', gamma, delta, epsilon and zeta-1. COP1 induces membrane curvature during budding<ref>PMID:21893600</ref>.
	== Function ==		== Function ==