Cobra venom factor - Revision history

Joel L. Sussman at 23:48, 21 December 2022

Joel L. Sussman — Wed, 21 Dec 2022 23:48:09 GMT

←Older revision		Revision as of 23:48, 21 December 2022
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3pvm]], [[~~6i2x~~]] – CVF + hComplement C5 <br />	+	[[3pvm]], [[8ayh]] – CVF + hComplement C5 <br />
	[[3frp]] – CVF α,β,γ chains <br />		[[3frp]] – CVF α,β,γ chains <br />
	[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br />		[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br />

Michal Harel at 09:18, 6 July 2020

Michal Harel — Mon, 06 Jul 2020 09:18:15 GMT

←Older revision		Revision as of 09:18, 6 July 2020
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	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}		Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}

-	[[3pvm]] – CVF + hComplement C5 <br />	+	[[3pvm]], [[6i2x]] – CVF + hComplement C5 <br />
	[[3frp]] – CVF α,β,γ chains <br />		[[3frp]] – CVF α,β,γ chains <br />
	[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br />		[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br />

Michal Harel at 11:54, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 11:54:36 GMT

←Older revision		Revision as of 11:54, 8 December 2015
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	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='350' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>		<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='350' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>
-	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.	+	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.<ref>PMID:15159065</ref>
	===Structure===		===Structure===

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	[[3prx]] – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7<br />		[[3prx]] – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7<br />

-		+	== References ==
		+	<references/>

	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 11:51, 8 December 2015

Michal Harel — Tue, 08 Dec 2015 11:51:06 GMT

←Older revision		Revision as of 11:51, 8 December 2015
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-	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='~~500~~' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>	+	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='350' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>
	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.		'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.
	===Structure===		===Structure===

Alexander Berchansky at 12:44, 9 June 2015

Alexander Berchansky — Tue, 09 Jun 2015 12:44:43 GMT

←Older revision		Revision as of 12:44, 9 June 2015
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-	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.	+	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='right' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>
-		+	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.
-		+
-	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>	+
	===Structure===		===Structure===

Michal Harel at 09:27, 5 December 2013

Michal Harel — Thu, 05 Dec 2013 09:27:44 GMT

←Older revision		Revision as of 09:27, 5 December 2013
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-	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (PDB entry [[3frp]])'>	+	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'>
	===Structure===		===Structure===

Michal Harel at 08:16, 11 July 2013

Michal Harel — Thu, 11 Jul 2013 08:16:32 GMT

←Older revision		Revision as of 08:16, 11 July 2013
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-	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor (PDB entry [[3frp]])'>	+	<StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (PDB entry [[3frp]])'>
	===Structure===		===Structure===

Alexander Berchansky at 16:47, 21 March 2013

Alexander Berchansky — Thu, 21 Mar 2013 16:47:32 GMT

←Older revision		Revision as of 16:47, 21 March 2013
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	Convertase formation is upregulated by CVF and is enhanced by the added stability of CVF when compared to native convertases. The absence of binding sites for factor H, factor I, complement receptor 1, decay-accelerating factor (DAF), and membrane co-factor protein in CVF may also contribute to its increased half-life. Factor H and CR1 binding sites in C3b depend on the presence of two glutamic acid residues E744 and E747 located in the MG6 domain. CVF, however, has aspartic acid and lysine residues in these corresponding locations: 728D and 731K. Similarly, segments of the TED domain are absent from CVF and contribute to the lack of binding ability by factor H. Additionally a binding site for properdin, a stabilizing protein, has been proposed at 1381-1414 of the beta chain.		Convertase formation is upregulated by CVF and is enhanced by the added stability of CVF when compared to native convertases. The absence of binding sites for factor H, factor I, complement receptor 1, decay-accelerating factor (DAF), and membrane co-factor protein in CVF may also contribute to its increased half-life. Factor H and CR1 binding sites in C3b depend on the presence of two glutamic acid residues E744 and E747 located in the MG6 domain. CVF, however, has aspartic acid and lysine residues in these corresponding locations: 728D and 731K. Similarly, segments of the TED domain are absent from CVF and contribute to the lack of binding ability by factor H. Additionally a binding site for properdin, a stabilizing protein, has been proposed at 1381-1414 of the beta chain.
-		+	</StructureSection>
	== 3D Structures of Cobra venom factor ==		== 3D Structures of Cobra venom factor ==

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-	~~</StructureSection>~~	+
		+	[[Category:Topic Page]]

Michal Harel at 11:29, 13 March 2013

Michal Harel — Wed, 13 Mar 2013 11:29:35 GMT

←Older revision		Revision as of 11:29, 13 March 2013
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-	'''Cobra Venom factor''' is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.	+	'''Cobra Venom factor''' (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.


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	Convertase formation is upregulated by CVF and is enhanced by the added stability of CVF when compared to native convertases. The absence of binding sites for factor H, factor I, complement receptor 1, decay-accelerating factor (DAF), and membrane co-factor protein in CVF may also contribute to its increased half-life. Factor H and CR1 binding sites in C3b depend on the presence of two glutamic acid residues E744 and E747 located in the MG6 domain. CVF, however, has aspartic acid and lysine residues in these corresponding locations: 728D and 731K. Similarly, segments of the TED domain are absent from CVF and contribute to the lack of binding ability by factor H. Additionally a binding site for properdin, a stabilizing protein, has been proposed at 1381-1414 of the beta chain.		Convertase formation is upregulated by CVF and is enhanced by the added stability of CVF when compared to native convertases. The absence of binding sites for factor H, factor I, complement receptor 1, decay-accelerating factor (DAF), and membrane co-factor protein in CVF may also contribute to its increased half-life. Factor H and CR1 binding sites in C3b depend on the presence of two glutamic acid residues E744 and E747 located in the MG6 domain. CVF, however, has aspartic acid and lysine residues in these corresponding locations: 728D and 731K. Similarly, segments of the TED domain are absent from CVF and contribute to the lack of binding ability by factor H. Additionally a binding site for properdin, a stabilizing protein, has been proposed at 1381-1414 of the beta chain.
		+
		+	== 3D Structures of Cobra venom factor ==
		+
		+	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
		+
		+	[[3pvm]] – CVF + hComplement C5 <br />
		+	[[3frp]] – CVF α,β,γ chains <br />
		+	[[3hrz]] – CVF α,β,γ chains + hComplement C5 (mutant)<br />
		+	[[3hs0]] – CVF α,β,γ chains + hComplement B (mutant)<br />
		+	[[3prx]] – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7<br />


	</StructureSection>		</StructureSection>

Michal Harel at 11:17, 13 March 2013

Michal Harel — Wed, 13 Mar 2013 11:17:57 GMT

←Older revision		Revision as of 11:17, 13 March 2013
Line 1:		Line 1:
-	Cobra Venom factor is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.	+	'''Cobra Venom factor''' is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.