Colicin 10 - Revision history

Gemma McGoldrick: /* Killing Activities */

Gemma McGoldrick — Fri, 25 Mar 2011 18:54:50 GMT

Killing Activities

←Older revision		Revision as of 18:54, 25 March 2011
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	==Killing Activities==		==Killing Activities==
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		+	Colicin 10 has [[Pore Formation]] activities, whereby it inserts into the membrane of the targeted cell from the cytoplasm, and forms a pore. This causes depolarisation of the membrane, which is needed for the cell to synthesise ATP. Once this process is halted, the cell cannot survive and so dies.

Gemma McGoldrick: /* Mechanism of uptake */

Gemma McGoldrick — Fri, 25 Mar 2011 18:54:33 GMT

Mechanism of uptake

←Older revision		Revision as of 18:54, 25 March 2011
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	==Mechanism of uptake==		==Mechanism of uptake==
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		+	The receptor binding domain of the colicin binds to the outer membrane receptor Tsx on the target cell; it is a constitutively expressed protein parasitised by the colicin. The translocation domain then recruits proteins from the [[Ton]] system to translocate the protein across the membrane and into the cytoplasm.

	==Killing Activities==		==Killing Activities==

Gemma McGoldrick: /* Synthesis and release */

Gemma McGoldrick — Fri, 25 Mar 2011 18:54:17 GMT

Synthesis and release

←Older revision		Revision as of 18:54, 25 March 2011
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	==Synthesis and release==		==Synthesis and release==
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		+	The operon for colicin 9 is encoded on a plasmid in the cytoplasm of the ''E. coli''. This operon also encodes its [[Colicin Immunity Protein]], [[Cti]], to protect the membrane of the cell from the pore forming activities of the colicin, alongside a protein to aid the release of the colicin outside the cell.
		+
		+	Once produced, the immunity protein inserts into the membrane to prevent pore formation by the colicin.

	==Mechanism of uptake==		==Mechanism of uptake==

	==Killing Activities==		==Killing Activities==

Gemma McGoldrick at 19:41, 9 February 2011

Gemma McGoldrick — Wed, 09 Feb 2011 19:41:44 GMT

←Older revision		Revision as of 19:41, 9 February 2011
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-	Colicin 10 is a type of [[Colicin]], a bacteriocin made by "E. ~~Coli"~~ which acts against other nearby "E. ~~Coli"~~ to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell.	+	Colicin 10 is a type of [[Colicin]], a bacteriocin made by ''E. coli'' which acts against other nearby ''E. coli'' to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell.

	==Synthesis and release==		==Synthesis and release==

Gemma McGoldrick: New page: Colicin 10 is a type of Colicin, a bacteriocin made by "E. Coli" which acts against other nearby "E. Coli" to kill them by forming a pore in the membrane, leading to depolarisation of ...

Gemma McGoldrick — Sat, 04 Dec 2010 17:14:58 GMT

New page: Colicin 10 is a type of Colicin, a bacteriocin made by "E. Coli" which acts against other nearby "E. Coli" to kill them by forming a pore in the membrane, leading to depolarisation of ...

New page

Colicin 10 is a type of [[Colicin]], a bacteriocin made by "E. Coli" which acts against other nearby "E. Coli" to kill them by forming a pore in the membrane, leading to depolarisation of the membrane which kills the cell.

==Synthesis and release==

==Mechanism of uptake==

==Killing Activities==