Cyclin-dependent kinase - Revision history

Alexander Berchansky at 10:48, 29 October 2023

Alexander Berchansky — Sun, 29 Oct 2023 10:48:56 GMT

←Older revision		Revision as of 10:48, 29 October 2023
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	•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]] and [[Palbociclib]]. <br />		•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]] and [[Palbociclib]]. <br />
	*'''CDK5''' binds p53 and functions during transcription<ref>PMID:12832492</ref>. <br />		*'''CDK5''' binds p53 and functions during transcription<ref>PMID:12832492</ref>. <br />
-	•'''CDK6''' binds cyclin D and functions during the G1 phase<ref>PMID:8114739</ref>. See also [[Palbociclib]]. <br />	+	•'''CDK6''' binds cyclin D and functions during the G1 phase<ref>PMID:8114739</ref>. See also [[Palbociclib]] and [[Abemaciclib]]. <br />
	*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle<ref>PMID:9372954</ref>.<br />		*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle<ref>PMID:9372954</ref>.<br />
	•'''CDK8''' binds cyclin C and functions during transcription<ref>PMID:20098423</ref>.<br />		•'''CDK8''' binds cyclin C and functions during transcription<ref>PMID:20098423</ref>.<br />

Alexander Berchansky at 12:27, 12 October 2023

Alexander Berchansky — Thu, 12 Oct 2023 12:27:20 GMT

←Older revision		Revision as of 12:27, 12 October 2023
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	== Function ==		== Function ==

-	'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are [[serine/threonine protein kinases]] which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />	+	'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are [[serine/threonine protein kinases]] which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein [[cyclin]]. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />

	• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression<ref>PMID:18408765</ref> <br />		• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression<ref>PMID:18408765</ref> <br />

Alexander Berchansky at 10:28, 11 October 2023

Alexander Berchansky — Wed, 11 Oct 2023 10:28:59 GMT

←Older revision		Revision as of 10:28, 11 October 2023
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	• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it<ref>PMID:1396589</ref>. See also [[Intrinsically Disordered Protein]].<br />		• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it<ref>PMID:1396589</ref>. See also [[Intrinsically Disordered Protein]].<br />
	•'''CDK3''' binds cyclin C and functions during the G1 phase<ref>PMID:27420775</ref>. <br />		•'''CDK3''' binds cyclin C and functions during the G1 phase<ref>PMID:27420775</ref>. <br />
-	•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />	+	•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]] and [[Palbociclib]]. <br />
	*'''CDK5''' binds p53 and functions during transcription<ref>PMID:12832492</ref>. <br />		*'''CDK5''' binds p53 and functions during transcription<ref>PMID:12832492</ref>. <br />
-	•'''CDK6''' binds cyclin D and functions during the G1 phase<ref>PMID:8114739</ref>. <br />	+	•'''CDK6''' binds cyclin D and functions during the G1 phase<ref>PMID:8114739</ref>. See also [[Palbociclib]]. <br />
	*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle<ref>PMID:9372954</ref>.<br />		*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle<ref>PMID:9372954</ref>.<br />
	•'''CDK8''' binds cyclin C and functions during transcription<ref>PMID:20098423</ref>.<br />		•'''CDK8''' binds cyclin C and functions during transcription<ref>PMID:20098423</ref>.<br />

Alexander Berchansky at 11:49, 12 February 2020

Alexander Berchansky — Wed, 12 Feb 2020 11:49:54 GMT

←Older revision		Revision as of 11:49, 12 February 2020
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	== Function ==		== Function ==

-	'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />	+	'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are [[serine/threonine protein kinases]] which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />

	• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression<ref>PMID:18408765</ref> <br />		• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression<ref>PMID:18408765</ref> <br />

Michal Harel at 08:38, 22 May 2019

Michal Harel — Wed, 22 May 2019 08:38:03 GMT

←Older revision		Revision as of 08:38, 22 May 2019
Line 5:		Line 5:
	'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />		'''Cyclin-dependent kinase''' (CDK) or '''Cell division protein kinase''' are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.<ref>PMID:11742345</ref><br />

-	• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression. <br />	+	• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression<ref>PMID:18408765</ref> <br />
-	• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br />	+	• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it<ref>PMID:1396589</ref>. See also [[Intrinsically Disordered Protein]].<br />
-	•'''CDK3''' binds cyclin C and functions during the G1 phase. <br />	+	•'''CDK3''' binds cyclin C and functions during the G1 phase<ref>PMID:27420775</ref>. <br />
	•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />		•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />
-	*'''CDK5''' binds p53 and functions during transcription. <br />	+	*'''CDK5''' binds p53 and functions during transcription<ref>PMID:12832492</ref>. <br />
-	•'''CDK6''' binds cyclin D and functions during the G1 phase. <br />	+	•'''CDK6''' binds cyclin D and functions during the G1 phase<ref>PMID:8114739</ref>. <br />
-	*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle.<br />	+	*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle<ref>PMID:9372954</ref>.<br />
-	•'''CDK8''' binds cyclin C and functions during transcription.<br />	+	•'''CDK8''' binds cyclin C and functions during transcription<ref>PMID:20098423</ref>.<br />
-	•'''CDK12''' phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.<br />	+	•'''CDK12''' phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation<ref>PMID:30487607</ref>.<br />
-	•'''CDK13''' is required for RNA splicing. <br />	+	•'''CDK13''' is required for RNA splicing<ref>PMID:30319007</ref>. <br />
-	•'''CDK16''' plays a role in vesicle-mediated transport processes and exocytosis.	+	•'''CDK16''' plays a role in vesicle-mediated transport processes and exocytosis<ref>PMID:28057719</ref>.

	See also [[Proteins involved in cancer]].		See also [[Proteins involved in cancer]].
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	== Relevance ==		== Relevance ==

-	CDK is a potential target for anti-cancer therapy.	+	CDK is a potential target for anti-cancer therapy. Overexprssion of CDK2 is indicator of oral cancer<ref>PMID:11267947</ref>. CDK2 may be a suitable drug target for melanoma<ref>PMID:15607961</ref>. Inhibition of CDK5 alleviates the cardiac phenotypes of Timothy Syndrome<ref>PMID:28648896</ref>. Up-regulated CDK6 activity is associated with several types of cancers and thus its inhibitors can serve as cancer drug targets<ref>PMID:26315616</ref>. Overexprssion of CDK7 is associated with unfavorable prognosis of oral squamous cells carcinoma<ref>PMID:30473182</ref>. CDK16 negatively modulates p53 signaling pathway to promote radio resistance and hence represents a therapeutic target for lung cancer radiotherapy<ref>PMID:23944296</ref>.
		+
		+	== Disease ==
		+
		+	CDK12 mutations have been found in several malignancies including ovarian carcinoma<ref>PMID:29090014</ref>.

	== Structural highlights ==		== Structural highlights ==
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	</StructureSection>		</StructureSection>
-	==3D structures of cyclin-dependent kinase==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*CDK1
-
-	**[[1dks]] – hCDK1 + phosphate - human<br />
-	**[[1dkt]] – hCDK1 + vanadate <br />
-	**[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br />
-	**[[4y72]], [[4yc3]], [[5hq0]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br />
-	**[[6gu7]] – hCDK1 + CDK regulatory subunit 2 + inhibitor<br />
-	**[[5lqf]], [[6gu4]], [[6gu3]], [[6gu2]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1 + inhibitor<br />
-
-	*CDK2
-
-	**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]] – hCDK2 – human<br />
-	**[[1b39]] - hCDK2 T160P<br />
-	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]], [[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]], [[5osj]], [[5oo0]], [[5mhq]], [[5k4j]], [[5jq8]], [[5jq5]], [[5iey]], [[5iex]], [[5fp6]], [[5fp5]], [[5d1j]], [[5ank]], [[5anj]], [[5ani]], [[5ang]], [[5ane]], [[5and]], [[5a14]], [[4d1z]], [[4d1x]], [[6guk]], [[6guh]] – hCDK2 + inhibitor<br />
-	**[[6q3b]], [[6q3c]], [[6q3f]], [[6q48]], [[6q49]], [[6q4a]], [[6q4b]], [[6q4c]], [[6q4d]], [[6q4e]], [[6q4f]], [[6q4g]], [[6q4h]], [[6q4i]], [[6q4j]], [[6q4k]] – hCDK2 + fraglite<br />
-	**[[2ds1]], [[5osm]], [[5oo3]], [[5oo1]] – hCDK2 (mutant) + inhibitor<br />
-	**[[5iev]] – hCDK2 + drug<br />
-	**[[1fq1]] - hCDK2 + cyclin-dependent kinase inhibitor 3<br />
-	**[[5uq3]] - hCDK2 + speedy protein A + cyclin-dependent kinase inhibitor 3<br />
-	**[[5uq2]], [[5uq1]] - hCDK2 + speedy protein A <br />
-	**[[1buh]] – hCDK2 + protein CKSHS1<br />
-	**[[4erw]] – hCDK2 + staurosporine<br />
-
-	*CDK2+cyclin
-
-	**[[5if1]] – hCDK2 + cyclin A2 <br />
-	**[[2jgz]] - hCDK2 T160P + cyclin B1<br />
-	**[[1w98]], [[5l2w]] - hCDK2 + cyclin E1<br />
-	**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br />
-	**[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]], [[6gva]], [[6guf]], [[6gue]], [[6guc]] – hCDK2 + cyclin A2 + inhibitor<br />
-	**[[6ath]] - hCDK2 T160P+ cyclin A2 + CDK inhibitor 1B<br />
-	**[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[5cyi]], [[5nev]], [[5lmk]] - hCDK2 T160P + cyclin A2 + inhibitor<br />
-	**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2 + peptide ligand<br />
-	**[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br />
-	**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br />
-	**[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br />
-	**[[1f5q]] - hCDK2 + γ herpesvirus cyclin <br />
-
-	*CDK3
-
-	**[[1fpz]] – hCDK3 (mutant)
-
-	*CDK4
-
-	**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br />
-	**[[3g33]] - hCDK4 + cyclin D3<br />
-	**[[5fwp]], [[5fwm]], [[5fwl]], [[5fwk]] - hCDK4-P + HSP 90 + CDC37 – cryo-EM<br />
-
-	*CDK5
-
-	**[[1h4l]] – hCDK5 + CDK5 activator<br />
-	**[[1ung]], [[1unh]], [[1unl]] - hCDK5 (mutant) + CDK5 activator + inhibitor<br />
-	**[[4au8]] – hCDK5 + inhibitor<br />
-	**[[3o0g]] - hCDK5 + ATP analog + CDK5 activator<br />
-
-	*CDK6
-
-	**[[1bi7]] – hCDK6 + multiple tumor suppressor<br />
-	**[[1bi8]], [[1blx]] – hCDK6 + CDK protein inhibitor<br />
-	**[[1g3n]] – hCDK6 + cyclin D homolog + CDK protein inhibitor<br />
-	**[[1jow]] – hCDK6 + V-cyclin<br />
-	**[[3nup]], [[3nux]], [[4aua]], [[4ez5]] – hCDK6 + inhibitor<br />
-	**[[5l2t]], [[5l2s]], [[5l2i]] – hCDK6 + drug<br />
-	**[[1xo2]], [[2f2c]], [[2euf]], [[4tth]] – hCDK6 + V-cyclin + inhibitor<br />
-
-	*CDK7
-
-	**[[1ua2]] – hCDK7<br />
-
-	*CDK8
-
-	**[[4g6l]], [[4crl]] – hCDK8 + cyclin C <br />
-	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]] – hCDK8 + cyclin C + inhibitor<br />
-
-	*CDK9
-
-	**[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br />
-	**[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br />
-	**[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]], [[6gzh]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br />
-	**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br />
-	**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br />
-	**[[5l1z]], [[6cyt]] – hCDK9-P + cyclin T1 + HIV-1 TAT + AF4/FMR2 + RNA<br />
-	**[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br />
-	**[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br />
-
-	*CDK12 kinase domain
-
-	**[[4un0]] – hCDK12-P + cyclin K<br />
-	**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />
-	**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />
-	**[[6b3e]], [[5acb]], [[6ckx]] – hCDK12-P + cyclin K + inhibitor<br />
-
-	*CDK13
-
-	**[[5efq]] – hCDK13-P residues 694-1039 + cyclin K + ADP<br />
-
-	*CDK16

-	**[[3mtl]], [[5g6v]] – hCDK16 (mutant) + indirubin<br />
-	}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 07:55, 22 May 2019

Michal Harel — Wed, 22 May 2019 07:55:34 GMT

←Older revision		Revision as of 07:55, 22 May 2019
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	The kinase <scene name='48/487539/Cv/5'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/6'>cleft between the small N-lobe and the large C-lobe</scene>. <scene name='48/487539/Cv/7'>Phosphorylated Thr</scene> near the binding site is required for kinase activity.<ref>PMID:18574471</ref>		The kinase <scene name='48/487539/Cv/5'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/6'>cleft between the small N-lobe and the large C-lobe</scene>. <scene name='48/487539/Cv/7'>Phosphorylated Thr</scene> near the binding site is required for kinase activity.<ref>PMID:18574471</ref>
		+
		+	==3D structures of cyclin-dependent kinase==
		+	[[Cyclin-dependent kinase 3D structures]]
		+
	</StructureSection>		</StructureSection>
	==3D structures of cyclin-dependent kinase==		==3D structures of cyclin-dependent kinase==
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	**[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br />		**[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br />
	**[[4y72]], [[4yc3]], [[5hq0]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br />		**[[4y72]], [[4yc3]], [[5hq0]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br />
-	**[[5lqf]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1 + inhibitor<br />	+	**[[6gu7]] – hCDK1 + CDK regulatory subunit 2 + inhibitor<br />
		+	**[[5lqf]], [[6gu4]], [[6gu3]], [[6gu2]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1 + inhibitor<br />

	*CDK2		*CDK2
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	**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]] – hCDK2 – human<br />		**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]] – hCDK2 – human<br />
	**[[1b39]] - hCDK2 T160P<br />		**[[1b39]] - hCDK2 T160P<br />
-	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]], [[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]], [[5osj]], [[5oo0]], [[5mhq]], [[5k4j]], [[5jq8]], [[5jq5]], [[5iey]], [[5iex]], [[5fp6]], [[5fp5]], [[5d1j]], [[5ank]], [[5anj]], [[5ani]], [[5ang]], [[5ane]], [[5and]], [[5a14]], [[4d1z]], [[4d1x]] – hCDK2 + inhibitor<br />	+	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]], [[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]], [[5osj]], [[5oo0]], [[5mhq]], [[5k4j]], [[5jq8]], [[5jq5]], [[5iey]], [[5iex]], [[5fp6]], [[5fp5]], [[5d1j]], [[5ank]], [[5anj]], [[5ani]], [[5ang]], [[5ane]], [[5and]], [[5a14]], [[4d1z]], [[4d1x]], [[6guk]], [[6guh]] – hCDK2 + inhibitor<br />
-	**[[2ds1]], [[5osm]] – hCDK2 (mutant) + inhibitor<br />	+	**[[6q3b]], [[6q3c]], [[6q3f]], [[6q48]], [[6q49]], [[6q4a]], [[6q4b]], [[6q4c]], [[6q4d]], [[6q4e]], [[6q4f]], [[6q4g]], [[6q4h]], [[6q4i]], [[6q4j]], [[6q4k]] – hCDK2 + fraglite<br />
		+	**[[2ds1]], [[5osm]], [[5oo3]], [[5oo1]] – hCDK2 (mutant) + inhibitor<br />
	**[[5iev]] – hCDK2 + drug<br />		**[[5iev]] – hCDK2 + drug<br />
	**[[1fq1]] - hCDK2 + cyclin-dependent kinase inhibitor 3<br />		**[[1fq1]] - hCDK2 + cyclin-dependent kinase inhibitor 3<br />
Line 57:		Line 63:
	**[[5if1]] – hCDK2 + cyclin A2 <br />		**[[5if1]] – hCDK2 + cyclin A2 <br />
	**[[2jgz]] - hCDK2 T160P + cyclin B1<br />		**[[2jgz]] - hCDK2 T160P + cyclin B1<br />
-	**[[1w98]], [[~~5t2w~~]] - hCDK2 + cyclin E1<br />	+	**[[1w98]], [[5l2w]] - hCDK2 + cyclin E1<br />
	**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br />		**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br />
-	**[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]] – hCDK2 + cyclin A2 + inhibitor<br />	+	**[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]], [[6gva]], [[6guf]], [[6gue]], [[6guc]] – hCDK2 + cyclin A2 + inhibitor<br />
		+	**[[6ath]] - hCDK2 T160P+ cyclin A2 + CDK inhibitor 1B<br />
	**[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[5cyi]], [[5nev]], [[5lmk]] - hCDK2 T160P + cyclin A2 + inhibitor<br />		**[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[5cyi]], [[5nev]], [[5lmk]] - hCDK2 T160P + cyclin A2 + inhibitor<br />
	**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2 + peptide ligand<br />		**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2 + peptide ligand<br />
Line 65:		Line 72:
	**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br />		**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br />
	**[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br />		**[[4i3z]], [[4ii5]] - hCDK2 T160P + cyclin A2+ ADP<br />
		+	**[[1f5q]] - hCDK2 + γ herpesvirus cyclin <br />

	*CDK3		*CDK3
Line 74:		Line 82:
	**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br />		**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br />
	**[[3g33]] - hCDK4 + cyclin D3<br />		**[[3g33]] - hCDK4 + cyclin D3<br />
-	**[[5fwp]], [[5fwm]], [[5fwl]], [[~~5fwl~~]] - hCDK4-P + HSP 90 + CDC37 – cryo-EM<br />	+	**[[5fwp]], [[5fwm]], [[5fwl]], [[5fwk]] - hCDK4-P + HSP 90 + CDC37 – cryo-EM<br />

	*CDK5		*CDK5
Line 99:		Line 107:
	*CDK8		*CDK8

-	**[[4g6l]], [[~~4cri~~]] – hCDK8 + cyclin C <br />	+	**[[4g6l]], [[4crl]] – hCDK8 + cyclin C <br />
	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]] – hCDK8 + cyclin C + inhibitor<br />		**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]] – hCDK8 + cyclin C + inhibitor<br />

Line 106:		Line 114:
	**[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br />		**[[3blh]], [[4ec8]], [[4ec9]] – hCDK9-P + cyclin T1 (mutant)<br />
	**[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br />		**[[3blq]] – hCDK9-P + cyclin T1 (mutant) + ATP<br />
-	**[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br />	+	**[[3lq5]], [[3my1]], [[3tn8]], [[3tnh]], [[3tni]], [[4bcf]], [[4bcg]], [[4bch]], [[4bci]], [[4bcj]], [[6gzh]] – hCDK9-P + cyclin T1 (mutant) + inhibitor<br />
	**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br />		**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br />
	**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br />		**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br />
-	**[[5l1z]] – hCDK9-P + cyclin T1 + HIV-1 TAT + AF4/FMR2 + RNA<br />	+	**[[5l1z]], [[6cyt]] – hCDK9-P + cyclin T1 + HIV-1 TAT + AF4/FMR2 + RNA<br />
	**[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br />		**[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br />
	**[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br />		**[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br />
Line 118:		Line 126:
	**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />		**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />
	**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />		**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />
-	**[[6b3e]], [[5acb]] – hCDK12-P + cyclin K + inhibitor<br />	+	**[[6b3e]], [[5acb]], [[6ckx]] – hCDK12-P + cyclin K + inhibitor<br />

	*CDK13		*CDK13

Alexander Berchansky at 07:14, 18 February 2019

Alexander Berchansky — Mon, 18 Feb 2019 07:14:08 GMT

←Older revision		Revision as of 07:14, 18 February 2019
Line 25:		Line 25:
	== Structural highlights ==		== Structural highlights ==

-	The kinase <scene name='48/487539/Cv/3'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/2'>cleft between the small N-lobe and the large C-lobe</scene>. <scene name='48/487539/Cv/4'>Phosphorylated Thr</scene> near the binding site is required for kinase activity.<ref>PMID:18574471</ref>	+	The kinase <scene name='48/487539/Cv/5'>ATP-binding active site</scene> is located in a <scene name='48/487539/Cv/6'>cleft between the small N-lobe and the large C-lobe</scene>. <scene name='48/487539/Cv/7'>Phosphorylated Thr</scene> near the binding site is required for kinase activity.<ref>PMID:18574471</ref>
	</StructureSection>		</StructureSection>
	==3D structures of cyclin-dependent kinase==		==3D structures of cyclin-dependent kinase==

Michal Harel at 09:43, 16 April 2018

Michal Harel — Mon, 16 Apr 2018 09:43:47 GMT

←Older revision		Revision as of 09:43, 16 April 2018
Line 7:		Line 7:
	• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression. <br />		• '''CDK1''' binds cyclin and forms a complex which phosphorylates a variety of substrates which are involved in cell cycle progression. <br />
	• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br />		• '''CDK2''' is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin A2. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. See also [[Intrinsically Disordered Protein]].<br />
-	• '''CDK3''' binds cyclin C and functions during the G1 phase. <br />	+	•'''CDK3''' binds cyclin C and functions during the G1 phase. <br />
-	~~• For~~ details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />	+	•For details on '''CDK4''' see [[Cyclin Dependent Kinase-4]]. <br />
-	* '''CDK5''' binds p53 and functions during transcription. <br />	+	*'''CDK5''' binds p53 and functions during transcription. <br />
-	• '''CDK6''' binds cyclin D and functions during the G1 phase. <br />	+	•'''CDK6''' binds cyclin D and functions during the G1 phase. <br />
-	• '''CDK7''' may serve as a direct link between transcription regulation and the cell cycle.<br />	+	*'''CDK7''' may serve as a direct link between transcription regulation and the cell cycle.<br />
-	• '''CDK8''' binds cyclin C and functions during transcription.<br />	+	•'''CDK8''' binds cyclin C and functions during transcription.<br />
-	• '''CDK12''' phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.<br />	+	•'''CDK12''' phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.<br />
-	• '''CDK16''' plays a role in vesicle-mediated transport processes and exocytosis.	+	•'''CDK13''' is required for RNA splicing. <br />
		+	•'''CDK16''' plays a role in vesicle-mediated transport processes and exocytosis.

	See also [[Proteins involved in cancer]].		See also [[Proteins involved in cancer]].
Line 41:		Line 42:
	*CDK2		*CDK2

-	**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]] – hCDK2 – human<br />	+	**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]], [[5ano]] – hCDK2 – human<br />
	**[[1b39]] - hCDK2 T160P<br />		**[[1b39]] - hCDK2 T160P<br />
-	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]],[[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]] – hCDK2 + inhibitor<br />	+	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]], [[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]], [[5osj]], [[5oo0]], [[5mhq]], [[5k4j]], [[5jq8]], [[5jq5]], [[5iey]], [[5iex]], [[5fp6]], [[5fp5]], [[5d1j]], [[5ank]], [[5anj]], [[5ani]], [[5ang]], [[5ane]], [[5and]], [[5a14]], [[4d1z]], [[4d1x]] – hCDK2 + inhibitor<br />
-	**[[2ds1]] – hCDK2 (mutant) + inhibitor<br />	+	**[[2ds1]], [[5osm]] – hCDK2 (mutant) + inhibitor<br />
-	**[[1fq1]] - hCDK2 +cyclin-dependent kinase inhibitor 3<br />	+	**[[5iev]] – hCDK2 + drug<br />
-	**[[1buh]] – hCDK2+ protein CKSHS1<br />	+	**[[1fq1]] - hCDK2 + cyclin-dependent kinase inhibitor 3<br />
		+	**[[5uq3]] - hCDK2 + speedy protein A + cyclin-dependent kinase inhibitor 3<br />
		+	**[[5uq2]], [[5uq1]] - hCDK2 + speedy protein A <br />
		+	**[[1buh]] – hCDK2 + protein CKSHS1<br />
	**[[4erw]] – hCDK2 + staurosporine<br />		**[[4erw]] – hCDK2 + staurosporine<br />

	*CDK2+cyclin		*CDK2+cyclin

		+	**[[5if1]] – hCDK2 + cyclin A2 <br />
	**[[2jgz]] - hCDK2 T160P + cyclin B1<br />		**[[2jgz]] - hCDK2 T160P + cyclin B1<br />
-	**[[1w98]] - hCDK2 + cyclin E1<br />	+	**[[1w98]], [[5t2w]] - hCDK2 + cyclin E1<br />
	**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br />		**[[2wma]], [[2wmb]], [[2x1n]], [[2wev]], [[2wfy]], [[2whb]], [[2v22]], [[2cch]], [[1okv]], [[1okw]], [[1ol1]], [[1ol2]], [[1urc]], [[1h24]], [[1h25]], [[1h26]], [[1h27]], [[1h28]], [[1gy3]], [[3qhr]], [[3qhw]] - hCDK2 + cyclin A2+peptide ligand<br />
	**[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]] – hCDK2 + cyclin A2 + inhibitor<br />		**[[2wpa]], [[2wxv]], [[2wih]], [[2wip]], [[3f5x]], [[3eoc]], [[3eid]], [[3ej1]], [[2uzb]], [[2uzd]], [[2uze]], [[2uzl]], [[2uzn]], [[2uzo]], [[2uue]], [[2i40]], [[2bkz]], [[2c5n]], [[2c5o]], [[2c5v]], [[2c5x]], [[2c5y]], [[1ykr]], [[2c4g]], [[1p5e]], [[1pkd]], [[1fin]], [[4bcm]], [[4bcn]], [[4bco]], [[4bcp]], [[4bcq]], [[4cfm]], [[4cfn]], [[4cfu]], [[4cfv]], [[4cfw]], [[4cfx]], [[4fx3]] – hCDK2 + cyclin A2 + inhibitor<br />
-	**[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]] - hCDK2 T160P+ cyclin A2 + inhibitor<br />	+	**[[3ddp]], [[3dog]], [[3ddq]], [[3bht]], [[3bhu]], [[3bhv]], [[2iw6]], [[2iw8]], [[2iw9]], [[2g9x]], [[2cjm]], [[1oi9]], [[1oiu]], [[1oiy]], [[1ogu]], [[1h1p]], [[1h1q]], [[1h1r]], [[1h1s]], [[1jst]], [[3tnw]], [[4bck]], [[4eoi]], [[4eoj]], [[4eok]], [[4eol]], [[4eom]], [[4eon]], [[4eoo]], [[4eop]], [[4eoq]], [[4eor]], [[4eos]], [[5cyi]], [[5nev]], [[5lmk]] - hCDK2 T160P + cyclin A2 + inhibitor<br />
-	**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2+peptide ligand<br />	+	**[[2cci]], [[1qmz]] - hCDK2 T160P + cyclin A2 + peptide ligand<br />
	**[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br />		**[[1e9h]] - hCDK2 T160P + cyclin A3 + inhibitor<br />
	**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br />		**[[1jsu]] - hCDK2 T160P + cyclin A2+ protein P27<br />
Line 68:		Line 73:

	**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br />		**[[2w96]], [[2w99]], [[2w9f]], [[2w9z]] – hCDK4 kinase domain + cyclin D1<br />
-	**[[3g33]] - hCDK4 + cyclin D3	+	**[[3g33]] - hCDK4 + cyclin D3<br />
		+	**[[5fwp]], [[5fwm]], [[5fwl]], [[5fwl]] - hCDK4-P + HSP 90 + CDC37 – cryo-EM<br />

	*CDK5		*CDK5
Line 84:		Line 90:
	**[[1jow]] – hCDK6 + V-cyclin<br />		**[[1jow]] – hCDK6 + V-cyclin<br />
	**[[3nup]], [[3nux]], [[4aua]], [[4ez5]] – hCDK6 + inhibitor<br />		**[[3nup]], [[3nux]], [[4aua]], [[4ez5]] – hCDK6 + inhibitor<br />
		+	**[[5l2t]], [[5l2s]], [[5l2i]] – hCDK6 + drug<br />
	**[[1xo2]], [[2f2c]], [[2euf]], [[4tth]] – hCDK6 + V-cyclin + inhibitor<br />		**[[1xo2]], [[2f2c]], [[2euf]], [[4tth]] – hCDK6 + V-cyclin + inhibitor<br />

Line 93:		Line 100:

	**[[4g6l]], [[4cri]] – hCDK8 + cyclin C <br />		**[[4g6l]], [[4cri]] – hCDK8 + cyclin C <br />
-	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]] ~~– hCDK8 + cyclin C + inhibitor<br />~~	+	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]], [[5xs2]], [[5xqx]], [[4f7s]] – hCDK8 + cyclin C + inhibitor<br />
-	**[[4f7s]] – hCDK8 + cyclin C + ~~phenylethyl-quinazolin-amine~~<br />	+

	*CDK9		*CDK9
Line 103:		Line 109:
	**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br />		**[[3blr]] – hCDK9-P + cyclin T1 + flavopiridol<br />
	**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br />		**[[3mi9]], [[3mia]] – hCDK9-P + cyclin T1 + HIV-1 TAT<br />
		+	**[[5l1z]] – hCDK9-P + cyclin T1 + HIV-1 TAT + AF4/FMR2 + RNA<br />
	**[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br />		**[[4or5]], [[4ogr]] – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein<br />
	**[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br />		**[[4imy]] – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein<br />

-	*CDK12	+	*CDK12 kinase domain

	**[[4un0]] – hCDK12-P + cyclin K<br />		**[[4un0]] – hCDK12-P + cyclin K<br />
	**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />		**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />
	**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />		**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />
		+	**[[6b3e]], [[5acb]] – hCDK12-P + cyclin K + inhibitor<br />
		+
		+	*CDK13
		+
		+	**[[5efq]] – hCDK13-P residues 694-1039 + cyclin K + ADP<br />

	*CDK16		*CDK16

Michal Harel at 10:37, 5 April 2017

Michal Harel — Wed, 05 Apr 2017 10:37:07 GMT

←Older revision		Revision as of 10:37, 5 April 2017
Line 36:		Line 36:
	**[[1dkt]] – hCDK1 + vanadate <br />		**[[1dkt]] – hCDK1 + vanadate <br />
	**[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br />		**[[4yc6]] – hCDK1 + CDK regulatory subunit 1<br />
-	**[[4y72]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br />	+	**[[4y72]], [[4yc3]], [[5hq0]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1<br />
		+	**[[5lqf]] – hCDK1 + CDK regulatory subunit 2 + cyclin B1 + inhibitor<br />

	*CDK2		*CDK2
Line 42:		Line 43:
	**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]] – hCDK2 – human<br />		**[[1pw2]], [[1hck]], [[1hcl]], [[1b38]], [[4ek3]] – hCDK2 – human<br />
	**[[1b39]] - hCDK2 T160P<br />		**[[1b39]] - hCDK2 T160P<br />
-	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]],[[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]] – hCDK2 + inhibitor<br />	+	**[[3ns9]], [[3le6]], [[2xmy]], [[2xnb]], [[3lfn]], [[3lfq]], [[3lfs]], [[3ig7]], [[3igg]], [[3fz1]], [[3ezr]], [[3ezv]], [[2w1h]], [[2w17]], [[2w05]], [[2w06]], [[2r64]], [[2vta]], [[2vth]], [[2vti]], [[2vtj]], [[2vtl]], [[2vtm]], [[2vtn]], [[2vto]], [[2vtp]], [[2vtq]], [[2vtr]], [[2vts]], [[2vtt]], [[2vu3]], [[2vv9]], [[2r3f]], [[2r3g]], [[2r3h]], [[2r3i]], [[2r3j]], [[2r3k]], [[2r3l]], [[2r3m]], [[2r3n]], [[2r3o]], [[2r3p]], [[2r3q]], [[2r3r]], [[2j9m]], [[2v0d]], [[2duv]], [[2clx]], [[2fvd]], [[2a4l]], [[1w8c]], [[2a0c]], [[2exm]], [[2bpm]], [[2c68]], [[2c69]], [[2c6i]], [[2c6k]], [[2c6l]], [[2c6m]], [[2c6o]], [[2c6t]], [[2btr]], [[2bts]], [[2b52]], [[2b53]], [[2b54]], [[2b55]], [[2bhe]], [[2bhh]], [[1y8y]], [[1y91]], [[1wcc]], [[1w0x]], [[1pye]], [[1vyz]], [[1vyw]], [[1v1k]], [[1urw]], [[1pxm]], [[1pxn]], [[1pxo]], [[1pxp]], [[1r78]], [[1pf8]], [[1pxi]], [[1pxj]], [[1pxk]], [[1pxl]], [[1oiq]], [[1oir]], [[1oit]], [[1p2a]], [[1h00]], [[1h01]], [[1h07]], [[1h08]], [[1h0v]], [[1h0w]], [[1gz8]], [[1ke5]], [[1ke6]], [[1ke7]], [[1ke8]], [[1ke9]], [[1gih]], [[1gii]], [[1gij]], [[1jvp]], [[1g5s]], [[1jsv]], [[1e1v]], [[1e1x]], [[1fvt]], [[1fvv]], [[1di8]], [[1dm2]], [[1ckp]], [[1aq1]], [[3pxf]], [[3pxq]], [[3pxr]], [[3pxy]], [[3pxz]], [[3py0]], [[3py1]], [[3pj8]], [[3s2p]],[[3ql8]], [[3qqf]], [[3qqg]], [[3qqh]], [[3qqj]], [[3qqk]], [[3qql]], [[3qrt]], [[3qru]], [[3qtq]], [[3qtr]], [[3qts]], [[3qtu]], [[3qtw]], [[3qtx]], [[3qtz]], [[3qu0]], [[3qwj]], [[3qwk]], [[3qx2]], [[3qx4]], [[3qxo]], [[3qxp]], [[3qzf]], [[3qzg]], [[3qzh]], [[3qzi]], [[3r1q]], [[3r1s]], [[3r1y]], [[3r28]], [[3r6x]], [[3r71]], [[3r73]], [[3r7e]], [[3r7i]], [[3r7u]], [[3r7v]], [[3r7y]], [[3r83]], [[3r8l]], [[3r8m]], [[3r8p]], [[3r8u]], [[3r8v]], [[3r8z]], [[3r9d]], [[3r9h]], [[3r9n]], [[3r9o]], [[3rah]], [[3rai]], [[3rak]], [[3ral]], [[3rjc]], [[3rk5]], [[3rk7]], [[3rk9]], [[3rkb]], [[3rm6]], [[3rm7]], [[3rmf]], [[3rni]], [[3roy]], [[3rpo]], [[3rpr]], [[3rpv]], [[3rpy]], [[3rzb]], [[3s00]], [[3s0o]], [[3s1h]], [[3sqq]], [[3sw4]], [[3sw7]], [[3ti1]], [[3tiy]], [[3tiz]], [[3uli]], [[3unj]], [[3unk]], [[3wbl]], [[4acm]], [[4bgh]], [[4ek4]], [[4ek5]], [[4ek6]], [[4ek8]], [[4ez3]], [[4ez7]], [[4fkg]], [[4fki]], [[4fkj]], [[4fkl]], [[4fko]], [[4fkp]], [[4fkq]], [[4fkr]], [[4fks]], [[4fkt]], [[4fku]], [[4fkv]], [[4fkw]], [[4gcj]], [[4kd1]], [[4lyn]], [[4nj3]], [[4bzd]], [[4rj3]] – hCDK2 + inhibitor<br />
	**[[2ds1]] – hCDK2 (mutant) + inhibitor<br />		**[[2ds1]] – hCDK2 (mutant) + inhibitor<br />
	**[[1fq1]] - hCDK2 +cyclin-dependent kinase inhibitor 3<br />		**[[1fq1]] - hCDK2 +cyclin-dependent kinase inhibitor 3<br />
Line 91:		Line 92:
	*CDK8		*CDK8

-	**[[4g6l]] – hCDK8 + cyclin C <br />	+	**[[4g6l]], [[4cri]] – hCDK8 + cyclin C <br />
-	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]] – hCDK8 + cyclin C + inhibitor<br />	+	**[[3rgf]], [[4f6s]], [[4f6u]], [[4f6w]], [[4f70]], [[4f7j]], [[4f7l]], [[4f7n]], [[4c4l]], [[5bnj]], [[5cei]], [[5fgk]], [[5hbe]], [[5hbh]], [[5hbj]], [[5hnb]], [[5hvy]], [[5i5z]], [[5icp]], [[5idn]], [[5idp]] – hCDK8 + cyclin C + inhibitor<br />
	**[[4f7s]] – hCDK8 + cyclin C + phenylethyl-quinazolin-amine<br />		**[[4f7s]] – hCDK8 + cyclin C + phenylethyl-quinazolin-amine<br />

Line 113:		Line 114:
	*CDK16		*CDK16

-	**[[3mtl]] – hCDK16 (mutant) + indirubin<br />	+	**[[3mtl]], [[5g6v]] – hCDK16 (mutant) + indirubin<br />
	}}		}}
	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

Michal Harel at 09:44, 16 November 2016

Michal Harel — Wed, 16 Nov 2016 09:44:41 GMT

←Older revision		Revision as of 09:44, 16 November 2016
Line 107:		Line 107:
	*CDK12		*CDK12

-	**~~[[4cjy]],~~ [[4un0]] – hCDK12-P + cyclin K<br />	+	**[[4un0]] – hCDK12-P + cyclin K<br />
	**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />		**[[4nst]] – hCDK12-P + cyclin K + AlF3<br />
	**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />		**[[4cxa]] – hCDK12-P + cyclin K + AMPPNP<br />