Emily Ellis/Sandbox - Revision history

Karsten Theis at 12:27, 24 February 2018

Karsten Theis — Sat, 24 Feb 2018 12:27:02 GMT

←Older revision		Revision as of 12:27, 24 February 2018
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-	==Leftovers==
-	<scene name='61/611451/Adrenergic_receptor/1'>adrenergic receptor</scene>.

	==Medical Uses==		==Medical Uses==

Emily Ellis at 19:19, 8 December 2014

Emily Ellis — Mon, 08 Dec 2014 19:19:04 GMT

←Older revision		Revision as of 19:19, 8 December 2014
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	==Medical Uses==		==Medical Uses==
	The drug Salbutamol is an asthma drug used to treat chronic bronchitis, COPD (chronic obstructive pulmonary disorder), and exercise-induced asthma. It is also known as Albuterol, Levalbuterol, and Proventil. It is generally an oral inhaler that is used for prevention and treatment of the symptoms that accompany the conditions mentioned before.		The drug Salbutamol is an asthma drug used to treat chronic bronchitis, COPD (chronic obstructive pulmonary disorder), and exercise-induced asthma. It is also known as Albuterol, Levalbuterol, and Proventil. It is generally an oral inhaler that is used for prevention and treatment of the symptoms that accompany the conditions mentioned before.
		+

	The drug itself is a racemic mixture, or combination of both the S-isomer (the mirror image) and the R-isomer (the drug). The R-isomer is 150 times more likely to bond with the beta2-adrenergic receptor than the S-isomer, but it is much less expensive for the drug companies to produce both isomers when creating the drugs. The beta2-adrenergic receptors (usually pulmonary) are 29 times more receptive to the Salbutamol than the beta1-adrenergic receptors, which are usually found in the heart.		The drug itself is a racemic mixture, or combination of both the S-isomer (the mirror image) and the R-isomer (the drug). The R-isomer is 150 times more likely to bond with the beta2-adrenergic receptor than the S-isomer, but it is much less expensive for the drug companies to produce both isomers when creating the drugs. The beta2-adrenergic receptors (usually pulmonary) are 29 times more receptive to the Salbutamol than the beta1-adrenergic receptors, which are usually found in the heart.
		+

	Some common brand names for the drug are: Aerolin, ProAir, and Ventolin.		Some common brand names for the drug are: Aerolin, ProAir, and Ventolin.

	<br>		<br>

Emily Ellis at 19:14, 8 December 2014

Emily Ellis — Mon, 08 Dec 2014 19:14:48 GMT

←Older revision		Revision as of 19:14, 8 December 2014
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	==Leftovers==		==Leftovers==
	<scene name='61/611451/Adrenergic_receptor/1'>adrenergic receptor</scene>.		<scene name='61/611451/Adrenergic_receptor/1'>adrenergic receptor</scene>.
		+
		+	==Medical Uses==
		+	The drug Salbutamol is an asthma drug used to treat chronic bronchitis, COPD (chronic obstructive pulmonary disorder), and exercise-induced asthma. It is also known as Albuterol, Levalbuterol, and Proventil. It is generally an oral inhaler that is used for prevention and treatment of the symptoms that accompany the conditions mentioned before.
		+
		+	The drug itself is a racemic mixture, or combination of both the S-isomer (the mirror image) and the R-isomer (the drug). The R-isomer is 150 times more likely to bond with the beta2-adrenergic receptor than the S-isomer, but it is much less expensive for the drug companies to produce both isomers when creating the drugs. The beta2-adrenergic receptors (usually pulmonary) are 29 times more receptive to the Salbutamol than the beta1-adrenergic receptors, which are usually found in the heart.
		+
		+	Some common brand names for the drug are: Aerolin, ProAir, and Ventolin.

	<br>		<br>

Karsten Theis at 17:58, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 17:58:59 GMT

←Older revision		Revision as of 17:58, 7 December 2014
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	*<jmol>		*<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [80,70,60,55,53]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [80,70,60,55,53,52]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Shave away</text>		<text>Shave away</text>
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	*<jmol>		*<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [55,60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [53,55,60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Put everything back</text>		<text>Put everything back</text>
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	The next scene shows salbutamol in red, and those parts of the receptor that surround it, called its binding site, in blue. Compare the blue parts to the box in the movie. It helps to use the "shave away" buttons above, and to rotate the view so it matches the view of the molecule in the movie.		The next scene shows salbutamol in red, and those parts of the receptor that surround it, called its binding site, in blue. Compare the blue parts to the box in the movie. It helps to use the "shave away" buttons above, and to rotate the view so it matches the view of the molecule in the movie.

-	<scene name='61/611451/Adrenergic_receptor/5'>~~Binding Site~~</scene>	+	With all those blue atoms, it becomes difficult to see the salbutamol. For the 3D printed model, we shaved away the binding site (blue box), but kept the entire salbutamol, so it sticks out of the box. In the browser, we can switch the receptor atoms to a smaller radius, connecting the atoms that are bonded, to give a better view of the <scene name='61/611451/Adrenergic_receptor/5'>binding site</scene>. Again, you can use the "shave away" buttons to help seeing the red molecule inside the blue binding site.

Karsten Theis at 17:52, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 17:52:30 GMT

←Older revision		Revision as of 17:52, 7 December 2014
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	*<jmol>		*<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [80,70,60,55]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [80,70,60,55,53]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Shave away</text>		<text>Shave away</text>
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	*<jmol>		*<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [55,60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Put everything back</text>		<text>Put everything back</text>

Karsten Theis at 17:08, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 17:08:47 GMT

←Older revision		Revision as of 17:08, 7 December 2014
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	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.		When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.

-	It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor, especially if we show name='61/611451/Adrenergic_receptor/7'>all the atoms</scene>. Use the links below to "shave away" parts of the molecule for a better look inside	+	It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor, especially if we show <scene name='61/611451/Adrenergic_receptor/7'>all the atoms</scene>. Use the links below to "shave away" parts of the molecule for a better look inside

	*<jmol>		*<jmol>

Karsten Theis at 17:07, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 17:07:18 GMT

←Older revision		Revision as of 17:07, 7 December 2014
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	'''What about the box?'''		'''What about the box?'''

-	[[Image:SalbutamolBox.jpg]]	+	[[Image:SalbutamolBox.jpg\|200px]]

	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.		When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.

Karsten Theis at 16:59, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 16:59:48 GMT

←Older revision		Revision as of 16:59, 7 December 2014
Line 32:		Line 32:
	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.		When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.

-	It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor. Use the links below to "shave away" parts of the molecule for a better look inside	+	It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor, especially if we show name='61/611451/Adrenergic_receptor/7'>all the atoms</scene>. Use the links below to "shave away" parts of the molecule for a better look inside

	*<jmol>		*<jmol>

Karsten Theis at 16:50, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 16:50:06 GMT

←Older revision		Revision as of 16:50, 7 December 2014
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	</jmolLink>		</jmolLink>
	</jmol>		</jmol>
		+
		+

	'''What about the box?'''		'''What about the box?'''

-	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the	+	[[Image:SalbutamolBox.jpg]]
-	<scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>	+
		+	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the <scene name='61/611451/Adrenergic_receptor/6'>adrenergic receptor</scene>.

	It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor. Use the links below to "shave away" parts of the molecule for a better look inside		It's a big molecule, and salbutamol is difficult to see because it is surrounded by the receptor. Use the links below to "shave away" parts of the molecule for a better look inside

-	<jmol>	+	*<jmol>
	<jmolLink>		<jmolLink>
	<script> slab on; depth 40; var a = [80,70,60,55]; for(var i IN a) {slab @i; delay 0.4;}		<script> slab on; depth 40; var a = [80,70,60,55]; for(var i IN a) {slab @i; delay 0.4;}
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	</jmol>		</jmol>

-	<jmol>	+	*<jmol>
	<jmolLink>		<jmolLink>
	<script> slab on; depth 40; var a = [60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}		<script> slab on; depth 40; var a = [60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}

Karsten Theis at 15:46, 7 December 2014

Karsten Theis — Sun, 07 Dec 2014 15:46:55 GMT

←Older revision		Revision as of 15:46, 7 December 2014
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	</jmol>		</jmol>

-	~~</StructureSection>~~	+	'''What about the box?'''
-		+
-	==What about the box?==	+

	When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the		When salbutamol acts in the body, it does so by binding to a receptor in the cell membrane. Receptors help to communicate between the outside of the cell and the inside of the cell, much like a window or a door bell helps people in a house learn about what is going on outside. The receptor salbutamol binds to is a protein called the
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	<jmol>		<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [~~90,~~80,70,60,55]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [80,70,60,55]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Shave away</text>		<text>Shave away</text>
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	<jmol>		<jmol>
	<jmolLink>		<jmolLink>
-	<script> slab on; depth 40; var a = [51,52,53,~~54,55~~]; for(var i IN a) {slab @i; delay 0.4;}	+	<script> slab on; depth 40; var a = [60,70,80,100]; for(var i IN a) {slab @i; delay 0.4;}
	</script>		</script>
	<text>Put everything back</text>		<text>Put everything back</text>
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	<scene name='61/611451/Adrenergic_receptor/5'>Binding Site</scene>		<scene name='61/611451/Adrenergic_receptor/5'>Binding Site</scene>

		+
		+	</StructureSection>