Exotoxin - Revision history

Michal Harel at 09:16, 25 June 2019

Michal Harel — Tue, 25 Jun 2019 09:16:44 GMT

←Older revision		Revision as of 09:16, 25 June 2019
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	</StructureSection>		</StructureSection>
-
-	==3D structures of exotoxin==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
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-	*''Pseudomonas aeruginosa'' exotoxin
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-	**[[1ikq]] – PaET A <br />
-	**[[1ikp]] – PaET A (mutant) <br />
-	**[[6edg]] – PaET A domain III mutant) <br />
-	**[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
-	**[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />
-	**[[1xk9]] – PaET A catalytic domain + inhibitor <br />
-	**[[1zm2]] – PaET A catalytic domain + diphthamide + adenosine diphosphoribose + EF-2 <br />
-	**[[1zm3]] – PaET A catalytic domain + diphthamide + EF-2 <br />
-	**[[3b78]], [[2zit]] – PaET A catalytic domain + diphthamide + NAD + EF-2 <br />
-	**[[3b82]], [[3b8h]] – PaET A catalytic domain (mutant) + diphthamide + NAD + EF-2 <br />
-	**[[1zm4]] – PaET A catalytic domain + diphthamide + NAD analog + EF-2 <br />
-	**[[1zm9]] – PaET A catalytic domain + diphthamide + inhibitor + EF-2 <br />
-
-	*''Vibrio cholerae'' exotoxin
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-	**[[2q5t]] – VcET <br />
-	**[[2q6m]], [[3ess]], [[3ki0]], [[3ki1]], [[3ki2]], [[3ki3]], [[3ki4]], [[3ki5]], [[3ki6]], [[3ki7]], [[3ny6]] – VcET catalytic domain + inhibitor <br />
-	**[[3q9o]] – VcET + NAD <br />
-
-	*''Streptococcus pyogenes'' exotoxin
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-	**[[1b1z]], [[1fnu]], [[1fnv]], [[1fnw]] – SpET A1 <br />
-	**[[1dki]] – SpET B<br />
-	**[[2jtc]] – SpET B (mutant) - NMR<br />
-	**[[1an8]] – SpET C<br />
-	**[[1et9]] – SpET H<br />
-	**[[2ici]] – SpET I<br />
-	**[[1ty0]] – SpET J<br />
-	**[[1ha5]], [[1uup]] – SpET A1 + Zn<br />
-	**[[1l0x]] – SpET A1 (mutant) + T cell receptor β chain<br />
-	**[[1pvj]] – SpET B + inhibitor <br />
-	**[[2uzj]] – SpET B + guanidine derivative <br />
-	**[[1eu4]] – SpET H + Zn<br />
-	**[[1ty2]] – SpET J + Zn<br />
-	**[[1ktk]] – SpET C (mutant) + T cell receptor β chain<br />
-	**[[1l0y]] – SpET A1 (mutant) + T cell receptor β chain + Zn<br />
-	**[[1hqr]] – SpRT C + antibody + myelin basic protein<br />
-
-	*''Staphylococcus aureus'' exotoxin
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-	**[[3ury]] – SaET <br />
-	**[[1v1o]], [[1v1p]] – SaET 1 <br />
-	**[[2r61]], [[2z8l]] – SaET 3<br />
-	**[[3r2i]] – SaET 5<br />
-	**[[4zys]] – SaET 6<br />
-	**[[3o13]] – SaET 15<br />
-	**[[3kls]] – SaET 1 (mutant) + complement C5<br />
-
-	*''Corynebacterium diphtheriae'' exotoxin See [[Diphtheria toxin]]
-
-	}}
-
-
-

	== References ==		== References ==

Michal Harel at 09:15, 25 June 2019

Michal Harel — Tue, 25 Jun 2019 09:15:31 GMT

←Older revision		Revision as of 09:15, 25 June 2019
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	<scene name='59/593276/Cv/4'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.		<scene name='59/593276/Cv/4'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.
		+
		+	==3D structures of exotoxin==
		+	[[Exotoxin 3D structures]]

	</StructureSection>		</StructureSection>
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	**[[1ikq]] – PaET A <br />		**[[1ikq]] – PaET A <br />
	**[[1ikp]] – PaET A (mutant) <br />		**[[1ikp]] – PaET A (mutant) <br />
		+	**[[6edg]] – PaET A domain III mutant) <br />
	**[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />		**[[1dma]] – PaET A catalytic domain + nicotinamide + AMP <br />
	**[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />		**[[1aer]] – PaET A catalytic domain + NAD analog + AMP <br />

Alexander Berchansky at 11:13, 14 March 2019

Alexander Berchansky — Thu, 14 Mar 2019 11:13:17 GMT

←Older revision		Revision as of 11:13, 14 March 2019
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.	+	<scene name='59/593276/Cv/4'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 08:08, 11 May 2017

Michal Harel — Thu, 11 May 2017 08:08:34 GMT

←Older revision		Revision as of 08:08, 11 May 2017
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	== Structural highlights ==		== Structural highlights ==

-	<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.	+	<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 08:07, 11 May 2017

Michal Harel — Thu, 11 May 2017 08:07:31 GMT

←Older revision		Revision as of 08:07, 11 May 2017
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	<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>		<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>
		+	== Function ==

-	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.	+	Exotoxins (ET) are toxins which are secreted by Gram-positive and Gram-negative bacteria<ref>PMID:17675409</ref>. ETs are heat labile. They are highly toxic and fatal in μg quantities. ETs bind to specific receptors and have no enzymatic activity.
		+
		+	== Relevance ==
		+
		+	Exotoxins are involved in tetanus, diphtheria and botulism.
		+
		+	== Structural highlights ==
		+
		+	<scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Michal Harel at 09:52, 10 May 2017

Michal Harel — Wed, 10 May 2017 09:52:21 GMT

←Older revision		Revision as of 09:52, 10 May 2017
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	**[[2r61]], [[2z8l]] – SaET 3<br />		**[[2r61]], [[2z8l]] – SaET 3<br />
	**[[3r2i]] – SaET 5<br />		**[[3r2i]] – SaET 5<br />
		+	**[[4zys]] – SaET 6<br />
	**[[3o13]] – SaET 15<br />		**[[3o13]] – SaET 15<br />
	**[[3kls]] – SaET 1 (mutant) + complement C5<br />		**[[3kls]] – SaET 1 (mutant) + complement C5<br />

Alexander Berchansky at 13:33, 14 February 2016

Alexander Berchansky — Sun, 14 Feb 2016 13:33:01 GMT

←Older revision		Revision as of 13:33, 14 February 2016
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	<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>		<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>

-	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref>	+	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref> Water molecules shown as red spheres.

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:31, 14 February 2016

Alexander Berchansky — Sun, 14 Feb 2016 13:31:52 GMT

←Older revision		Revision as of 13:31, 14 February 2016
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-	<StructureSection load='3q9o' size='~~350~~' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>	+	<StructureSection load='3q9o' size='400' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>

-	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref> .	+	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref>. <scene name='59/593276/Cv/3'>NAD binding site</scene> in ''Vibrio cholerae'' exotoxin (PDB code [[3q9o]]).<ref>PMID:22535961</ref>

	</StructureSection>		</StructureSection>

Alexander Berchansky at 13:11, 14 February 2016

Alexander Berchansky — Sun, 14 Feb 2016 13:11:37 GMT

←Older revision		Revision as of 13:11, 14 February 2016
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-	<StructureSection load='3q9o' size='~~340~~' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene=''>	+	<StructureSection load='3q9o' size='350' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene='59/593276/Cv/1'>

	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref> .		Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref> .

Michal Harel at 18:26, 20 January 2016

Michal Harel — Wed, 20 Jan 2016 18:26:53 GMT

←Older revision		Revision as of 18:26, 20 January 2016
Line 1:		Line 1:
	<StructureSection load='3q9o' size='340' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene=''>		<StructureSection load='3q9o' size='340' side='right' caption='Structure of Vibrio cholerae exotoxin complex with NAD and glycerol (PDB code [[3q9o]]).' scene=''>

-	~~== Function ==~~	+	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17675409</ref> .

-	Exotoxins (ET) are toxins which are secreted by bacteria<ref>PMID:17075409</ref> .
-
-	== Disease ==
-
-	== Relevance ==
-
-	== Structural highlights ==
	</StructureSection>		</StructureSection>