Exportin - Revision history

Michal Harel at 09:49, 25 June 2019

Michal Harel — Tue, 25 Jun 2019 09:49:43 GMT

←Older revision		Revision as of 09:49, 25 June 2019
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	<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'>		<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'>

-	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.	+	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br />
		+	*'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA.<br />
		+	*'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br />
		+	*'''XPO-4''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br />
		+	*'''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.<br />

	==Structural highlights ==		==Structural highlights ==

Michal Harel at 09:39, 25 June 2019

Michal Harel — Tue, 25 Jun 2019 09:39:01 GMT

←Older revision		Revision as of 09:39, 25 June 2019
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	</StructureSection>		</StructureSection>
-
-	==3D structures of exportin==
-
-	Updated on {{REVISIONDAY2}}-{{MONTHNAME\|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-	{{#tree:id=OrganizedByTopic\|openlevels=0\|
-
-	*XPO-1
-
-	**[[4bsm]], [[4bsn]] – hXPO – human<br />
-	**[[1w9c]] – hXPO C terminal 6 heat repeats <br />
-	**[[3vyc]] – yXPO (mutant) - yeast<br />
-	**[[4fgv]] – XPO – ''Chaetomium thermophilum''<br />
-
-	*XPO-1 complexes
-
-	**[[3gb8]] – hXPO + RNA U transporter 1 <br />
-	**[[3gjx]] – hXPO + RNA U transporter 1 + RAN<br />
-	**[[5dis]] – hXPO + RAN + RNA U transporter 1 + MBP<br />
-	**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[5jlj]] – yXPO (mutant) + RAN + RANBP1 <br />
-	**[[3wyf]] – yXPO + RAN + RANBP1 <br />
-	**[[3wyg]] – yXPO + RAN + PKI-α<br />
-	**[[5zpu]], [[5ytb]], [[5yst]], [[5uro]] - yXPO (mutant) + RAN + RANBP1 + GTP<br />
-	**[[5ysu]] - yXPO (mutant) + RAN + RANBP1 + GTP + plumbagin<br />
-	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + RAN + RANBP1 + antibiotic<br />
-	**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]], [[5dif]] - yXPO (mutant) + RAN + RANBP1 + signal peptide<br />
-	**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + RAN + RANBP1 + signal peptide<br />
-	**[[6cit]], [[6a38]] - yXPO + RAN + RANBP1 + NS2 peptide<br />
-	**[[6a3a]], [[6a3b]], [[6a3c]], [[6a3e]] - yXPO (mutant) + RAN + RANBP1 + NS2 peptide<br />
-	**[[5xoj]] - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP<br />
-	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RANBP1 - mouse<br />
-	**[[3nc1]] – mXPO + RANBP1<br />
-	**[[2l1l]] – hXPO residues 504-630 + PKI-α - NMR<br />
-
-	*XPO-t
-
-	**[[3ibv]] – fyXPO – fission yeast<br />
-	**[[3icq]] – fyXPO + RAN homolog + RNA <br />
-
-	*XPO-4
-
-	**[[5dlq]] – mXPO (mutant) + RAN + EIF5A1<br />
-
-	*XPO-5
-
-	**[[5yu7]] – hXPO <br />
-	**[[5yu6]] – hXPO + peptide + RAN <br />
-	**[[3a6p]] – hXPO + peptide + pre-microRNA <br />
-	}}

	== References ==		== References ==

Michal Harel at 09:37, 25 June 2019

Michal Harel — Tue, 25 Jun 2019 09:37:57 GMT

←Older revision		Revision as of 09:37, 25 June 2019
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	<scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>		<scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>
		+
		+	==3D structures of exportin==
		+	[[Exportin 3D structures]]
		+
	</StructureSection>		</StructureSection>

Line 32:		Line 36:
	**[[3wyf]] – yXPO + RAN + RANBP1 <br />		**[[3wyf]] – yXPO + RAN + RANBP1 <br />
	**[[3wyg]] – yXPO + RAN + PKI-α<br />		**[[3wyg]] – yXPO + RAN + PKI-α<br />
		+	**[[5zpu]], [[5ytb]], [[5yst]], [[5uro]] - yXPO (mutant) + RAN + RANBP1 + GTP<br />
		+	**[[5ysu]] - yXPO (mutant) + RAN + RANBP1 + GTP + plumbagin<br />
	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + RAN + RANBP1 + antibiotic<br />		**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + RAN + RANBP1 + antibiotic<br />
	**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]], [[5dif]] - yXPO (mutant) + RAN + RANBP1 + signal peptide<br />		**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]], [[5dif]] - yXPO (mutant) + RAN + RANBP1 + signal peptide<br />
	**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + RAN + RANBP1 + signal peptide<br />		**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + RAN + RANBP1 + signal peptide<br />
		+	**[[6cit]], [[6a38]] - yXPO + RAN + RANBP1 + NS2 peptide<br />
		+	**[[6a3a]], [[6a3b]], [[6a3c]], [[6a3e]] - yXPO (mutant) + RAN + RANBP1 + NS2 peptide<br />
	**[[5xoj]] - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP<br />		**[[5xoj]] - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP<br />
	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RANBP1 - mouse<br />		**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RANBP1 - mouse<br />
Line 51:		Line 59:
	*XPO-5		*XPO-5

		+	**[[5yu7]] – hXPO <br />
		+	**[[5yu6]] – hXPO + peptide + RAN <br />
	**[[3a6p]] – hXPO + peptide + pre-microRNA <br />		**[[3a6p]] – hXPO + peptide + pre-microRNA <br />
	}}		}}

Alexander Berchansky at 11:17, 14 March 2019

Alexander Berchansky — Thu, 14 Mar 2019 11:17:06 GMT

←Older revision		Revision as of 11:17, 14 March 2019
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-	<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/1'>	+	<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'>

	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.		'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.
Line 5:		Line 5:
	==Structural highlights ==		==Structural highlights ==

-	<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>.	+	<scene name='59/592125/Cv/10'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>.

-	<scene name='59/592125/Cv/6'>GTP binding site</scene>.	+	<scene name='59/592125/Cv/11'>GTP binding site</scene>.

-	<scene name='59/592125/Cv/8'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>	+	<scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>
	</StructureSection>		</StructureSection>

Michal Harel at 08:51, 22 May 2018

Michal Harel — Tue, 22 May 2018 08:51:37 GMT

←Older revision		Revision as of 08:51, 22 May 2018
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	**[[3gb8]] – hXPO + RNA U transporter 1 <br />		**[[3gb8]] – hXPO + RNA U transporter 1 <br />
-	**[[3gjx]] – hXPO + RNA U transporter 1 + ~~GTP-binding nuclear protein~~ RAN<br />	+	**[[3gjx]] – hXPO + RNA U transporter 1 + RAN<br />
-	**[[5dis]] – hXPO + ~~GTP-binding nuclear protein~~ RAN + RNA U transporter 1 + MBP<br />	+	**[[5dis]] – hXPO + RAN + RNA U transporter 1 + MBP<br />
-	**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[5jlj]] – yXPO (mutant) + ~~GTP-binding nuclear protein~~ RAN + ~~RAN-specific GTPase-activating protein~~ <br />	+	**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[5jlj]] – yXPO (mutant) + RAN + RANBP1 <br />
-	**[[3wyf]] – yXPO + ~~GTP-binding nuclear protein~~ RAN + ~~RAN-specific GTPase-activating protein~~ <br />	+	**[[3wyf]] – yXPO + RAN + RANBP1 <br />
-	**[[3wyg]] – yXPO + ~~GTP-binding nuclear protein~~ RAN + PKI-~~alpha~~<br />	+	**[[3wyg]] – yXPO + RAN + PKI-α<br />
-	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + ~~GTP-binding nuclear protein~~ RAN + ~~RAN-specific GTPase-activating protein~~ + antibiotic<br />	+	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + RAN + RANBP1 + antibiotic<br />
-	**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]] - yXPO (mutant) + ~~GTP-binding nuclear protein~~ RAN + ~~RAN-specific GTPase-activating protein~~ + signal peptide<br />	+	**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]], [[5dif]] - yXPO (mutant) + RAN + RANBP1 + signal peptide<br />
-	**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + ~~GTP-binding nuclear protein~~ RAN + ~~RAN~~-~~specific GTPase~~-~~activating protein~~ + ~~signal~~ peptide<br />	+	**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + RAN + RANBP1 + signal peptide<br />
-	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + ~~RAN-specific GTPase-activating protein~~ - mouse<br />	+	**[[5xoj]] - yXPO (mutant) + GSP1P + PKI-a + NUP42 peptide + GTP<br />
-	**[[3nc1]] – mXPO + ~~RAN-specific GTPase-activating protein~~<br />	+	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RANBP1 - mouse<br />
-	**[[2l1l]] – hXPO residues 504-630 + ~~cAMP~~-~~dependent protein kinase inhibitor~~ α - NMR<br />	+	**[[3nc1]] – mXPO + RANBP1<br />
		+	**[[2l1l]] – hXPO residues 504-630 + PKI-α - NMR<br />

	*XPO-t		*XPO-t

	**[[3ibv]] – fyXPO – fission yeast<br />		**[[3ibv]] – fyXPO – fission yeast<br />
-	**[[3icq]] – fyXPO + ~~GTP-binding nuclear protein~~ + RNA <br />	+	**[[3icq]] – fyXPO + RAN homolog + RNA <br />

	*XPO-4		*XPO-4

-	**[[5dlq]] – mXPO (mutant) + ~~GTP-binding nuclear protein~~ RAN + EIF5A1<br />	+	**[[5dlq]] – mXPO (mutant) + RAN + EIF5A1<br />

	*XPO-5		*XPO-5

Michal Harel at 10:36, 10 May 2017

Michal Harel — Wed, 10 May 2017 10:36:00 GMT

←Older revision		Revision as of 10:36, 10 May 2017
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	**[[3gb8]] – hXPO + RNA U transporter 1 <br />		**[[3gb8]] – hXPO + RNA U transporter 1 <br />
-	**[[3gjx]] – hXPO + RNA U transporter 1 + ~~GTPaseRan~~<br />	+	**[[3gjx]] – hXPO + RNA U transporter 1 + GTP-binding nuclear protein RAN<br />
-	**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]] – yXPO (mutant) + GTP-binding nuclear protein + ~~Ran~~-specific GTPase-activating protein <br />	+	**[[5dis]] – hXPO + GTP-binding nuclear protein RAN + RNA U transporter 1 + MBP<br />
-	**[[3wyf]] – yXPO + GTP-binding nuclear protein + ~~Ran~~-specific GTPase-activating protein <br />	+	**[[3m1i]], [[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[5jlj]] – yXPO (mutant) + GTP-binding nuclear protein RAN + RAN-specific GTPase-activating protein <br />
-	**[[3wyg]] – yXPO + GTP-binding nuclear protein + PKI-alpha<br />	+	**[[3wyf]] – yXPO + GTP-binding nuclear protein RAN + RAN-specific GTPase-activating protein <br />
-	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + GTP-binding nuclear protein + ~~Ran~~-specific GTPase-activating protein + antibiotic<br />	+	**[[3wyg]] – yXPO + GTP-binding nuclear protein RAN + PKI-alpha<br />
-	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + ~~GTPaseRan~~ - mouse<br />	+	**[[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb3]], [[4hb4]] – yXPO (mutant) + GTP-binding nuclear protein RAN + RAN-specific GTPase-activating protein + antibiotic<br />
-	**[[3nc1]] – mXPO + ~~GTPaseRan~~<br />	+	**[[5dh9]], [[5dha]], [[5dhf]], [[5di9]], [[5uwj]] - yXPO (mutant) + GTP-binding nuclear protein RAN + RAN-specific GTPase-activating protein + signal peptide<br />
		+	**[[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]], [[5uwi]], [[5uwh]] - yXPO + GTP-binding nuclear protein RAN + RAN-specific GTPase-activating protein + signal peptide<br />
		+	**[[3nby]], [[3nbz]], [[3nc0]] – mXPO + RNA U transporter 1 + RAN-specific GTPase-activating protein - mouse<br />
		+	**[[3nc1]] – mXPO + RAN-specific GTPase-activating protein<br />
	**[[2l1l]] – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR<br />		**[[2l1l]] – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR<br />

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	**[[3ibv]] – fyXPO – fission yeast<br />		**[[3ibv]] – fyXPO – fission yeast<br />
	**[[3icq]] – fyXPO + GTP-binding nuclear protein + RNA <br />		**[[3icq]] – fyXPO + GTP-binding nuclear protein + RNA <br />
		+
		+	*XPO-4
		+
		+	**[[5dlq]] – mXPO (mutant) + GTP-binding nuclear protein RAN + EIF5A1<br />

	*XPO-5		*XPO-5

Alexander Berchansky at 10:25, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 10:25:45 GMT

←Older revision		Revision as of 10:25, 15 February 2016
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	<scene name='59/592125/Cv/6'>GTP binding site</scene>.		<scene name='59/592125/Cv/6'>GTP binding site</scene>.

-	<scene name='59/592125/Cv/7'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>	+	<scene name='59/592125/Cv/8'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:22, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 10:22:05 GMT

←Older revision		Revision as of 10:22, 15 February 2016
Line 3:		Line 3:
	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.		'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.

-	==Structural ~~highlighta~~ ==	+	==Structural highlights ==

-	<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene> ~~(PDB code [[3icq]])~~.	+	<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene>.

-	<scene name='59/592125/Cv/6'>GTP binding site</scene>	+	<scene name='59/592125/Cv/6'>GTP binding site</scene>.
		+
		+	<scene name='59/592125/Cv/7'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 10:18, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 10:18:36 GMT

←Older revision		Revision as of 10:18, 15 February 2016
Line 3:		Line 3:
	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.		'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.

-	<scene name='59/592125/Cv/2'>~~yeast~~ exportin-5 with GTPaseRan, Mg+2 and RNA</scene> (PDB code [[3icq]]).	+	==Structural highlighta ==
		+
		+	<scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene> (PDB code [[3icq]]).
		+
		+	<scene name='59/592125/Cv/6'>GTP binding site</scene>
	</StructureSection>		</StructureSection>

Alexander Berchansky at 09:21, 15 February 2016

Alexander Berchansky — Mon, 15 Feb 2016 09:21:52 GMT

←Older revision		Revision as of 09:21, 15 February 2016
Line 3:		Line 3:
	'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.		'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.

		+	<scene name='59/592125/Cv/2'>yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene> (PDB code [[3icq]]).
	</StructureSection>		</StructureSection>